MOUSE:CMC1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Slc25a12 (synonyms: Aralar1)
Protein Name(s)	Calcium-binding mitochondrial carrier protein Aralar1 Mitochondrial aspartate glutamate carrier 1 Solute carrier family 25 member 12
External Links
UniProt	Q8BH59
EMBL	AK030595 AK083156 BX284624 BC060505
CCDS	CCDS16113.1
RefSeq	NP_766024.1
UniGene	Mm.146696 Mm.30928
ProteinModelPortal	Q8BH59
SMR	Q8BH59
BioGrid	219664
IntAct	Q8BH59
MINT	MINT-1843325
PhosphoSite	Q8BH59
MaxQB	Q8BH59
PaxDb	Q8BH59
PRIDE	Q8BH59
Ensembl	ENSMUST00000151937
GeneID	78830
KEGG	mmu:78830
UCSC	uc008kan.1
CTD	8604
MGI	MGI:1926080
eggNOG	NOG292991
GeneTree	ENSGT00530000062944
HOGENOM	HOG000180633
HOVERGEN	HBG005350
InParanoid	Q8BH59
KO	K15105
OMA	FESVLCT
OrthoDB	EOG70GMF1
PhylomeDB	Q8BH59
TreeFam	TF313209
Reactome	REACT_199101 REACT_263230
NextBio	349608
PRO	PR:Q8BH59
Proteomes	UP000000589
Bgee	Q8BH59
ExpressionAtlas	Q8BH59
Genevestigator	Q8BH59
GO	GO:0016021 GO:0005743 GO:0005739 GO:0005509 GO:0015183 GO:0005313 GO:0015810 GO:0089712 GO:0089711 GO:0015813 GO:0043490 GO:0051592
Gene3D	1.10.238.10 1.50.40.10
InterPro	IPR011992 IPR018247 IPR002048 IPR002067 IPR018108 IPR023395
Pfam	PF13405 PF00153
PRINTS	PR00926
SMART	SM00054
SUPFAM	SSF103506
PROSITE	PS00018 PS50222 PS50920

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0042802	identical protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O75746	F		Seeded From UniProt	complete
part_of	GO:0043209	myelin sheath	PMID:17634366^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000128)	Seeded From UniProt	complete
involved_in	GO:0051592	response to calcium ion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O75746	P		Seeded From UniProt	complete
involved_in	GO:0043490	malate-aspartate shuttle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O75746	P		Seeded From UniProt	complete
involved_in	GO:0015813	L-glutamate transmembrane transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O75746	P		Seeded From UniProt	complete
involved_in	GO:0015810	aspartate transmembrane transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O75746	P		Seeded From UniProt	complete
enables	GO:0015183	L-aspartate transmembrane transporter activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O75746	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O75746	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O75746	F		Seeded From UniProt	complete
enables	GO:0005313	L-glutamate transmembrane transporter activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O75746	F		Seeded From UniProt	complete
involved_in	GO:0043490	malate-aspartate shuttle	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1354721 MGI:MGI:1926080 PANTHER:PTN000640306 UniProtKB:O75746 UniProtKB:Q9UJS0	P		Seeded From UniProt	complete
involved_in	GO:0015813	L-glutamate transmembrane transport	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0037970 FB:FBgn0260743 PANTHER:PTN000640304 SGD:S000006225 UniProtKB:O75746 UniProtKB:Q9H936 UniProtKB:Q9UJS0	P		Seeded From UniProt	complete
involved_in	GO:0015810	aspartate transmembrane transport	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1354721 PANTHER:PTN000640306 SGD:S000006225 UniProtKB:O75746 UniProtKB:Q9UJS0	P		Seeded From UniProt	complete
enables	GO:0015183	L-aspartate transmembrane transporter activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000640306 SGD:S000006225 UniProtKB:O75746 UniProtKB:Q9UJS0	F		Seeded From UniProt	complete
enables	GO:0005313	L-glutamate transmembrane transporter activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1354721 PANTHER:PTN000640304 SGD:S000006225 UniProtKB:O75746 UniProtKB:Q9H936 UniProtKB:Q9UJS0	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051592	response to calcium ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75746	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043490	malate-aspartate shuttle	PMID:17213189^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3603462	P	occurs_in:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043490	malate-aspartate shuttle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75746	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75746	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015813	L-glutamate transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75746	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015810	aspartate transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75746	P		Seeded From UniProt	complete
enables	GO:0015183	L-aspartate transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75746	F		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	PMID:12865426^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:18614015^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:17213189^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3603462	C	part_of:(EMAPA:16105)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:14701727^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75746	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75746	F		Seeded From UniProt	complete
enables	GO:0005313	L-glutamate transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75746	F		Seeded From UniProt	complete
involved_in	GO:0070778	L-aspartate transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015183	P		Seeded From UniProt	complete
involved_in	GO:0070778	L-aspartate transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0015183	P		Seeded From UniProt	complete
involved_in	GO:0070778	L-aspartate transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015183	P		Seeded From UniProt	complete
involved_in	GO:0070778	L-aspartate transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015183	P		Seeded From UniProt	complete
involved_in	GO:2001171	positive regulation of ATP biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LX07 ensembl:ENSRNOP00000032909	P		Seeded From UniProt	complete
involved_in	GO:1904024	negative regulation of glucose catabolic process to lactate via pyruvate	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LX07 ensembl:ENSRNOP00000032909	P		Seeded From UniProt	complete
involved_in	GO:0043490	malate-aspartate shuttle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LX07 ensembl:ENSRNOP00000032909	P		Seeded From UniProt	complete
involved_in	GO:0031643	positive regulation of myelination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LX07 ensembl:ENSRNOP00000032909	P		Seeded From UniProt	complete
involved_in	GO:0010907	positive regulation of glucose metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LX07 ensembl:ENSRNOP00000032909	P		Seeded From UniProt	complete
involved_in	GO:0006537	glutamate biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LX07 ensembl:ENSRNOP00000032909	P		Seeded From UniProt	complete
involved_in	GO:0051592	response to calcium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75746 ensembl:ENSP00000388658	P		Seeded From UniProt	complete
involved_in	GO:0043490	malate-aspartate shuttle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75746 ensembl:ENSP00000388658	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75746 ensembl:ENSP00000388658	F		Seeded From UniProt	complete
involved_in	GO:0015813	L-glutamate transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75746 ensembl:ENSP00000388658	P		Seeded From UniProt	complete
involved_in	GO:0015810	aspartate transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75746 ensembl:ENSP00000388658	P		Seeded From UniProt	complete
enables	GO:0015183	L-aspartate transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75746 ensembl:ENSP00000388658	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75746 ensembl:ENSP00000388658	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75746 ensembl:ENSP00000388658	F		Seeded From UniProt	complete
enables	GO:0005313	L-glutamate transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75746 ensembl:ENSP00000388658	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002048	F		Seeded From UniProt	complete
enables	GO:0022857	transmembrane transporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002067 InterPro:IPR040062	F		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002067	P		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	PMID:14701727^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0999 UniProtKB-SubCell:SL-0168	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 Contreras, L et al. (2007) Ca2+ Activation kinetics of the two aspartate-glutamate mitochondrial carriers, aralar and citrin: role in the heart malate-aspartate NADH shuttle. J. Biol. Chem. 282 7098-106 PubMed GONUTS page
↑ Da Cruz, S et al. (2003) Proteomic analysis of the mouse liver mitochondrial inner membrane. J. Biol. Chem. 278 41566-71 PubMed GONUTS page
↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
↑ ^6.0 ^6.1 Sinasac, DS et al. (2004) Slc25a13-knockout mice harbor metabolic deficits but fail to display hallmarks of adult-onset type II citrullinemia. Mol. Cell. Biol. 24 527-36 PubMed GONUTS page

[PMID:17634366-1] Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17213189-3] 3.0 ^3.1 Contreras, L et al. (2007) Ca2+ Activation kinetics of the two aspartate-glutamate mitochondrial carriers, aralar and citrin: role in the heart malate-aspartate NADH shuttle. J. Biol. Chem. 282 7098-106 PubMed GONUTS page

[PMID:12865426-4] Da Cruz, S et al. (2003) Proteomic analysis of the mouse liver mitochondrial inner membrane. J. Biol. Chem. 278 41566-71 PubMed GONUTS page

[PMID:18614015-5] Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page

[PMID:14701727-6] 6.0 ^6.1 Sinasac, DS et al. (2004) Slc25a13-knockout mice harbor metabolic deficits but fail to display hallmarks of adult-onset type II citrullinemia. Mol. Cell. Biol. 24 527-36 PubMed GONUTS page

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MOUSE:CMC1

Contents

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Notes

References

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