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MOUSE:CLYBL
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Clybl (ECO:0000312 with MGI:MGI:1916884) (synonyms: Clb) | |
| Protein Name(s) | Citramalyl-CoA lyase, mitochondrial
Beta-methylmalate synthase Citrate lyase subunit beta-like protein, mitochondrial Citrate lyase beta-like Malate synthase | |
| External Links | ||
| UniProt | Q8R4N0 | |
| EMBL | AF428254 AK009345 BC023398 | |
| CCDS | CCDS27346.1 | |
| RefSeq | NP_083832.2 | |
| UniGene | Mm.34608 | |
| ProteinModelPortal | Q8R4N0 | |
| SMR | Q8R4N0 | |
| IntAct | Q8R4N0 | |
| MINT | Q8R4N0 | |
| STRING | 10090.ENSMUSP00000026625 | |
| iPTMnet | Q8R4N0 | |
| PhosphoSitePlus | Q8R4N0 | |
| REPRODUCTION-2DPAGE | Q8R4N0 | |
| EPD | Q8R4N0 | |
| MaxQB | Q8R4N0 | |
| PaxDb | Q8R4N0 | |
| PeptideAtlas | Q8R4N0 | |
| PRIDE | Q8R4N0 | |
| Ensembl | ENSMUST00000026625 | |
| GeneID | 69634 | |
| KEGG | mmu:69634 | |
| UCSC | uc007vax.2 | |
| CTD | 171425 | |
| MGI | MGI:1916884 | |
| eggNOG | ENOG410IGUQ COG2301 | |
| GeneTree | ENSGT00390000017163 | |
| HOGENOM | HOG000242281 | |
| HOVERGEN | HBG059382 | |
| InParanoid | Q8R4N0 | |
| KO | K11390 | |
| OMA | AWLFCPA | |
| OrthoDB | EOG091G0EXW | |
| PhylomeDB | Q8R4N0 | |
| TreeFam | TF313596 | |
| BRENDA | 4.1.3.6 | |
| ChiTaRS | Clybl | |
| PRO | PR:Q8R4N0 | |
| Proteomes | UP000000589 | |
| Bgee | ENSMUSG00000025545 | |
| CleanEx | MM_CLYBL | |
| Genevisible | Q8R4N0 | |
| GO | GO:0005739 GO:0047777 GO:0000287 GO:0004474 GO:0070207 GO:0106064 | |
| InterPro | IPR005000 IPR011206 IPR015813 | |
| Pfam | PF03328 | |
| PIRSF | PIRSF015582 | |
| SUPFAM | SSF51621 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0106121 |
positive regulation of cobalamin metabolic process |
ECO:0000315 |
P |
Fig 3Fshows that KO of CLYBL in mouse brown adipocytes results in reduced levels of conenzyme B12 signifying cell-autonomous loss of conezyme B12. This was shown using LC-MS-based metabolic profiling. |
complete | |||||
|
involved_in |
GO:0106064 |
regulation of cobalamin metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0047777 |
(3S)-citramalyl-CoA lyase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070207 |
protein homotrimerization |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004474 |
malate synthase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000287 |
magnesium ion binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0106064 |
regulation of cobalamin metabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1916884 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0047777 |
(3S)-citramalyl-CoA lyase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1916884 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0106064 |
regulation of cobalamin metabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0070207 |
protein homotrimerization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0047777 |
(3S)-citramalyl-CoA lyase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004474 |
malate synthase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000287 |
magnesium ion binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0106064 |
regulation of cobalamin metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8N0X4 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070207 |
protein homotrimerization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8N0X4 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0047777 |
(3S)-citramalyl-CoA lyase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8N0X4 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004474 |
malate synthase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8N0X4 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000287 |
magnesium ion binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8N0X4 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004474 |
malate synthase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0047777 |
(3S)-citramalyl-CoA lyase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016829 |
lyase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Shen, H et al. (2017) The Human Knockout Gene CLYBL Connects Itaconate to Vitamin B. Cell 171 771-782.e11 PubMed GONUTS page
- ↑ 2.0 2.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
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