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MOUSE:CLD1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Cldn1
Protein Name(s) Claudin-1
External Links
UniProt O88551
EMBL AF072127
AK028428
AK036762
AK036780
AK040604
AK054207
AK081601
BC002003
CCDS CCDS28087.1
RefSeq NP_057883.1
UniGene Mm.289441
ProteinModelPortal O88551
SMR O88551
BioGrid 198743
IntAct O88551
MINT MINT-113174
STRING 10090.ENSMUSP00000023154
PhosphoSite O88551
PaxDb O88551
PRIDE O88551
Ensembl ENSMUST00000023154
GeneID 12737
KEGG mmu:12737
UCSC uc007yuz.2
CTD 9076
MGI MGI:1276109
eggNOG NOG47316
HOGENOM HOG000220937
HOVERGEN HBG000643
InParanoid O88551
KO K06087
OMA IYEGLWM
OrthoDB EOG76HQ2T
PhylomeDB O88551
TreeFam TF331936
Reactome REACT_236746
NextBio 282042
PMAP-CutDB O88551
PRO PR:O88551
Proteomes UP000000589
Bgee O88551
CleanEx MM_CLDN1
ExpressionAtlas O88551
Genevestigator O88551
GO GO:0016324
GO:0030054
GO:0016021
GO:0005887
GO:0016328
GO:0005886
GO:0005923
GO:0042802
GO:0005198
GO:0016338
GO:0045216
GO:0061436
InterPro IPR006187
IPR003548
IPR017974
IPR004031
PANTHER PTHR12002
Pfam PF00822
PRINTS PR01077
PR01377
PROSITE PS01346

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0030054

cell junction

PMID:21983942[1]

ECO:0000314

C

Figure 2.

complete
CACAO 4103

part_of

GO:0030054

cell junction

PMID:21983942[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0061436

establishment of skin barrier

PMID:11889141[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:10562289[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O88551

F

Seeded From UniProt

complete

involved_in

GO:0016338

calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules

PMID:10508613[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:9647647[5]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005923

bicellular tight junction

PMID:11889141[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005923

bicellular tight junction

PMID:9647647[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:11889141[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903348

positive regulation of bicellular tight junction assembly

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68422

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090557

establishment of endothelial intestinal barrier

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68422

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070830

bicellular tight junction assembly

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O95832

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070673

response to interleukin-18

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68422

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0061772

xenobiotic transport across blood-nerve barrier

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68422

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0061436

establishment of skin barrier

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O95832

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051291

protein heterooligomerization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O95832

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051260

protein homooligomerization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O95832

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045216

cell-cell junction organization

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O95832

P

Seeded From UniProt

complete

part_of

GO:0016328

lateral plasma membrane

PMID:22275141[6]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17066)
  • part_of:(CL:0000083)

Seeded From UniProt

complete

part_of

GO:0016328

lateral plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68422

C

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

PMID:20089884[7]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0002326)

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68422

C

Seeded From UniProt

complete

part_of

GO:0016323

basolateral plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O95832

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008065

establishment of blood-nerve barrier

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68422

P

Seeded From UniProt

complete

part_of

GO:0005923

bicellular tight junction

PMID:22946046[8]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:35465)

Seeded From UniProt

complete

part_of

GO:0005923

bicellular tight junction

PMID:22275141[6]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32952)
  • part_of:(CL:0002064)|part_of:(EMAPA:32952)
  • part_of:(CL:0002079)

Seeded From UniProt

complete

part_of

GO:0005923

bicellular tight junction

PMID:16520537[9]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17373)
  • part_of:(CL:0000066)

Seeded From UniProt

complete

part_of

GO:0005923

bicellular tight junction

PMID:15775979[10]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:17525)

Seeded From UniProt

complete

part_of

GO:0005923

bicellular tight junction

PMID:12673830[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005923

bicellular tight junction

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O95832

C

Seeded From UniProt

complete

part_of

GO:0005923

bicellular tight junction

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68422

C

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O95832

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:15775979[10]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:17525)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68422

C

Seeded From UniProt

complete

enables

GO:0001618

virus receptor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O95832

F

Seeded From UniProt

complete

involved_in

GO:0046718

viral entry into host cell

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0001618

P

Seeded From UniProt

complete

involved_in

GO:0046718

viral entry into host cell

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0001618

P

Seeded From UniProt

complete

involved_in

GO:0070830

bicellular tight junction assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O95832
ensembl:ENSP00000295522

P

Seeded From UniProt

complete

involved_in

GO:0061436

establishment of skin barrier

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O95832
ensembl:ENSP00000295522

P

Seeded From UniProt

complete

involved_in

GO:0051291

protein heterooligomerization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O95832
ensembl:ENSP00000295522

P

Seeded From UniProt

complete

involved_in

GO:0051260

protein homooligomerization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O95832
ensembl:ENSP00000295522

P

Seeded From UniProt

complete

involved_in

GO:0045216

cell-cell junction organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O95832
ensembl:ENSP00000295522

P

Seeded From UniProt

complete

part_of

GO:0016323

basolateral plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O95832
ensembl:ENSP00000295522

C

Seeded From UniProt

complete

part_of

GO:0005923

bicellular tight junction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O95832
ensembl:ENSP00000295522

C

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O95832
ensembl:ENSP00000295522

C

Seeded From UniProt

complete

enables

GO:0001618

virus receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O95832
ensembl:ENSP00000295522

F

Seeded From UniProt

complete

involved_in

GO:1903545

cellular response to butyrate

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56745
ensembl:ENSRNOP00000002640

P

Seeded From UniProt

complete

involved_in

GO:1903348

positive regulation of bicellular tight junction assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56745
ensembl:ENSRNOP00000002640

P

Seeded From UniProt

complete

involved_in

GO:0097421

liver regeneration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56745
ensembl:ENSRNOP00000002640

P

Seeded From UniProt

complete

involved_in

GO:0090557

establishment of endothelial intestinal barrier

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56745
ensembl:ENSRNOP00000002640

P

Seeded From UniProt

complete

involved_in

GO:0071560

cellular response to transforming growth factor beta stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56745
ensembl:ENSRNOP00000002640

P

Seeded From UniProt

complete

involved_in

GO:0071548

response to dexamethasone

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56745
ensembl:ENSRNOP00000002640

P

Seeded From UniProt

complete

involved_in

GO:0071356

cellular response to tumor necrosis factor

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56745
ensembl:ENSRNOP00000002640

P

Seeded From UniProt

complete

involved_in

GO:0071346

cellular response to interferon-gamma

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56745
ensembl:ENSRNOP00000002640

P

Seeded From UniProt

complete

involved_in

GO:0071284

cellular response to lead ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56745
ensembl:ENSRNOP00000002640

P

Seeded From UniProt

complete

involved_in

GO:0070673

response to interleukin-18

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56745
ensembl:ENSRNOP00000002640

P

Seeded From UniProt

complete

involved_in

GO:0061772

xenobiotic transport across blood-nerve barrier

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56745
ensembl:ENSRNOP00000002640

P

Seeded From UniProt

complete

involved_in

GO:0045471

response to ethanol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56745
ensembl:ENSRNOP00000002640

P

Seeded From UniProt

complete

involved_in

GO:0042538

hyperosmotic salinity response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56745
ensembl:ENSRNOP00000002640

P

Seeded From UniProt

complete

involved_in

GO:0032496

response to lipopolysaccharide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56745
ensembl:ENSRNOP00000002640

P

Seeded From UniProt

complete

part_of

GO:0016328

lateral plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56745
ensembl:ENSRNOP00000002640

C

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56745
ensembl:ENSRNOP00000002640

C

Seeded From UniProt

complete

involved_in

GO:0009636

response to toxic substance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56745
ensembl:ENSRNOP00000002640

P

Seeded From UniProt

complete

involved_in

GO:0008065

establishment of blood-nerve barrier

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56745
ensembl:ENSRNOP00000002640

P

Seeded From UniProt

complete

involved_in

GO:0007568

aging

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56745
ensembl:ENSRNOP00000002640

P

Seeded From UniProt

complete

part_of

GO:0005923

bicellular tight junction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56745
ensembl:ENSRNOP00000002640

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56745
ensembl:ENSRNOP00000002640

C

Seeded From UniProt

complete

enables

GO:0005198

structural molecule activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003548
InterPro:IPR006187

F

Seeded From UniProt

complete

part_of

GO:0005923

bicellular tight junction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003548
InterPro:IPR006187

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004031

C

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

Reactome:R-MMU-420000

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-MMU-420000

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005923

bicellular tight junction

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0796
UniProtKB-SubCell:SL-0265

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0965

C

Seeded From UniProt

complete

part_of

GO:0016323

basolateral plasma membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0026

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Pfeiffer, F et al. (2011) Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis. Acta Neuropathol. 122 601-14 PubMed GONUTS page
  2. 2.0 2.1 2.2 Furuse, M et al. (2002) Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice. J. Cell Biol. 156 1099-111 PubMed GONUTS page
  3. Furuse, M et al. (1999) Manner of interaction of heterogeneous claudin species within and between tight junction strands. J. Cell Biol. 147 891-903 PubMed GONUTS page
  4. Kubota, K et al. (1999) Ca(2+)-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions. Curr. Biol. 9 1035-8 PubMed GONUTS page
  5. 5.0 5.1 Furuse, M et al. (1998) Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J. Cell Biol. 141 1539-50 PubMed GONUTS page
  6. 6.0 6.1 Westmoreland, JJ et al. (2012) Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation. Dev. Dyn. 241 583-94 PubMed GONUTS page
  7. Plante, I et al. (2010) Milk secretion and ejection are impaired in the mammary gland of mice harboring a Cx43 mutant while expression and localization of tight and adherens junction proteins remain unchanged. Biol. Reprod. 82 837-47 PubMed GONUTS page
  8. Guillemot, L et al. (2012) Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury. J. Cell. Sci. 125 5005-14 PubMed GONUTS page
  9. Ohta, H et al. (2006) Developmental changes in the expression of tight junction protein claudins in murine metanephroi and embryonic kidneys. J. Vet. Med. Sci. 68 149-55 PubMed GONUTS page
  10. 10.0 10.1 Tunggal, JA et al. (2005) E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J. 24 1146-56 PubMed GONUTS page
  11. Nico, B et al. (2003) Severe alterations of endothelial and glial cells in the blood-brain barrier of dystrophic mdx mice. Glia 42 235-51 PubMed GONUTS page