MOUSE:CLD1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Cldn1
Protein Name(s)	Claudin-1
External Links
UniProt	O88551
EMBL	AF072127 AK028428 AK036762 AK036780 AK040604 AK054207 AK081601 BC002003
CCDS	CCDS28087.1
RefSeq	NP_057883.1
UniGene	Mm.289441
ProteinModelPortal	O88551
SMR	O88551
BioGrid	198743
IntAct	O88551
MINT	MINT-113174
STRING	10090.ENSMUSP00000023154
PhosphoSite	O88551
PaxDb	O88551
PRIDE	O88551
Ensembl	ENSMUST00000023154
GeneID	12737
KEGG	mmu:12737
UCSC	uc007yuz.2
CTD	9076
MGI	MGI:1276109
eggNOG	NOG47316
HOGENOM	HOG000220937
HOVERGEN	HBG000643
InParanoid	O88551
KO	K06087
OMA	IYEGLWM
OrthoDB	EOG76HQ2T
PhylomeDB	O88551
TreeFam	TF331936
Reactome	REACT_236746
NextBio	282042
PMAP-CutDB	O88551
PRO	PR:O88551
Proteomes	UP000000589
Bgee	O88551
CleanEx	MM_CLDN1
ExpressionAtlas	O88551
Genevestigator	O88551
GO	GO:0016324 GO:0030054 GO:0016021 GO:0005887 GO:0016328 GO:0005886 GO:0005923 GO:0042802 GO:0005198 GO:0016338 GO:0045216 GO:0061436
InterPro	IPR006187 IPR003548 IPR017974 IPR004031
PANTHER	PTHR12002
Pfam	PF00822
PRINTS	PR01077 PR01377
PROSITE	PS01346

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0030054	cell junction	PMID:21983942^[1]	ECO:0000314			C		Figure 2.	complete CACAO 4103
part_of	GO:0030054	cell junction	PMID:21983942^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0061436	establishment of skin barrier	PMID:11889141^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:10562289^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O88551	F		Seeded From UniProt	complete
involved_in	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	PMID:10508613^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:9647647^[5]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	PMID:11889141^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	PMID:9647647^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:11889141^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903348	positive regulation of bicellular tight junction assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68422	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090557	establishment of endothelial intestinal barrier	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68422	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070830	bicellular tight junction assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95832	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070673	response to interleukin-18	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68422	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061772	xenobiotic transport across blood-nerve barrier	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68422	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061436	establishment of skin barrier	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95832	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051291	protein heterooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95832	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051260	protein homooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95832	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045216	cell-cell junction organization	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95832	P		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	PMID:22275141^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17066) part_of:(CL:0000083)	Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68422	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:20089884^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002326)	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68422	C		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95832	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008065	establishment of blood-nerve barrier	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68422	P		Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	PMID:22946046^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35465)	Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	PMID:22275141^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32952) part_of:(CL:0002064)\|part_of:(EMAPA:32952) part_of:(CL:0002079)	Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	PMID:16520537^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17373) part_of:(CL:0000066)	Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	PMID:15775979^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17525)	Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	PMID:12673830^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95832	C		Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68422	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95832	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15775979^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17525)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68422	C		Seeded From UniProt	complete
enables	GO:0001618	virus receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95832	F		Seeded From UniProt	complete
involved_in	GO:0046718	viral entry into host cell	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0001618	P		Seeded From UniProt	complete
involved_in	GO:0046718	viral entry into host cell	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0001618	P		Seeded From UniProt	complete
involved_in	GO:0070830	bicellular tight junction assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95832 ensembl:ENSP00000295522	P		Seeded From UniProt	complete
involved_in	GO:0061436	establishment of skin barrier	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95832 ensembl:ENSP00000295522	P		Seeded From UniProt	complete
involved_in	GO:0051291	protein heterooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95832 ensembl:ENSP00000295522	P		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95832 ensembl:ENSP00000295522	P		Seeded From UniProt	complete
involved_in	GO:0045216	cell-cell junction organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95832 ensembl:ENSP00000295522	P		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95832 ensembl:ENSP00000295522	C		Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95832 ensembl:ENSP00000295522	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95832 ensembl:ENSP00000295522	C		Seeded From UniProt	complete
enables	GO:0001618	virus receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95832 ensembl:ENSP00000295522	F		Seeded From UniProt	complete
involved_in	GO:1903545	cellular response to butyrate	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56745 ensembl:ENSRNOP00000002640	P		Seeded From UniProt	complete
involved_in	GO:1903348	positive regulation of bicellular tight junction assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56745 ensembl:ENSRNOP00000002640	P		Seeded From UniProt	complete
involved_in	GO:0097421	liver regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56745 ensembl:ENSRNOP00000002640	P		Seeded From UniProt	complete
involved_in	GO:0090557	establishment of endothelial intestinal barrier	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56745 ensembl:ENSRNOP00000002640	P		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56745 ensembl:ENSRNOP00000002640	P		Seeded From UniProt	complete
involved_in	GO:0071548	response to dexamethasone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56745 ensembl:ENSRNOP00000002640	P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56745 ensembl:ENSRNOP00000002640	P		Seeded From UniProt	complete
involved_in	GO:0071346	cellular response to interferon-gamma	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56745 ensembl:ENSRNOP00000002640	P		Seeded From UniProt	complete
involved_in	GO:0071284	cellular response to lead ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56745 ensembl:ENSRNOP00000002640	P		Seeded From UniProt	complete
involved_in	GO:0070673	response to interleukin-18	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56745 ensembl:ENSRNOP00000002640	P		Seeded From UniProt	complete
involved_in	GO:0061772	xenobiotic transport across blood-nerve barrier	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56745 ensembl:ENSRNOP00000002640	P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56745 ensembl:ENSRNOP00000002640	P		Seeded From UniProt	complete
involved_in	GO:0042538	hyperosmotic salinity response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56745 ensembl:ENSRNOP00000002640	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56745 ensembl:ENSRNOP00000002640	P		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56745 ensembl:ENSRNOP00000002640	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56745 ensembl:ENSRNOP00000002640	C		Seeded From UniProt	complete
involved_in	GO:0009636	response to toxic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56745 ensembl:ENSRNOP00000002640	P		Seeded From UniProt	complete
involved_in	GO:0008065	establishment of blood-nerve barrier	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56745 ensembl:ENSRNOP00000002640	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56745 ensembl:ENSRNOP00000002640	P		Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56745 ensembl:ENSRNOP00000002640	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56745 ensembl:ENSRNOP00000002640	C		Seeded From UniProt	complete
enables	GO:0005198	structural molecule activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003548 InterPro:IPR006187	F		Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003548 InterPro:IPR006187	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004031	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	Reactome:R-MMU-420000	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-MMU-420000	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0796 UniProtKB-SubCell:SL-0265	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0026	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Pfeiffer, F et al. (2011) Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis. Acta Neuropathol. 122 601-14 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Furuse, M et al. (2002) Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice. J. Cell Biol. 156 1099-111 PubMed GONUTS page
↑ Furuse, M et al. (1999) Manner of interaction of heterogeneous claudin species within and between tight junction strands. J. Cell Biol. 147 891-903 PubMed GONUTS page
↑ Kubota, K et al. (1999) Ca(2+)-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions. Curr. Biol. 9 1035-8 PubMed GONUTS page
↑ ^5.0 ^5.1 Furuse, M et al. (1998) Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J. Cell Biol. 141 1539-50 PubMed GONUTS page
↑ ^6.0 ^6.1 Westmoreland, JJ et al. (2012) Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation. Dev. Dyn. 241 583-94 PubMed GONUTS page
↑ Plante, I et al. (2010) Milk secretion and ejection are impaired in the mammary gland of mice harboring a Cx43 mutant while expression and localization of tight and adherens junction proteins remain unchanged. Biol. Reprod. 82 837-47 PubMed GONUTS page
↑ Guillemot, L et al. (2012) Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury. J. Cell. Sci. 125 5005-14 PubMed GONUTS page
↑ Ohta, H et al. (2006) Developmental changes in the expression of tight junction protein claudins in murine metanephroi and embryonic kidneys. J. Vet. Med. Sci. 68 149-55 PubMed GONUTS page
↑ ^10.0 ^10.1 Tunggal, JA et al. (2005) E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J. 24 1146-56 PubMed GONUTS page
↑ Nico, B et al. (2003) Severe alterations of endothelial and glial cells in the blood-brain barrier of dystrophic mdx mice. Glia 42 235-51 PubMed GONUTS page

[PMID:21983942-1] 1.0 ^1.1 Pfeiffer, F et al. (2011) Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis. Acta Neuropathol. 122 601-14 PubMed GONUTS page

[PMID:11889141-2] 2.0 ^2.1 ^2.2 Furuse, M et al. (2002) Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice. J. Cell Biol. 156 1099-111 PubMed GONUTS page

[PMID:10562289-3] Furuse, M et al. (1999) Manner of interaction of heterogeneous claudin species within and between tight junction strands. J. Cell Biol. 147 891-903 PubMed GONUTS page

[PMID:10508613-4] Kubota, K et al. (1999) Ca(2+)-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions. Curr. Biol. 9 1035-8 PubMed GONUTS page

[PMID:9647647-5] 5.0 ^5.1 Furuse, M et al. (1998) Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J. Cell Biol. 141 1539-50 PubMed GONUTS page

[PMID:22275141-6] 6.0 ^6.1 Westmoreland, JJ et al. (2012) Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation. Dev. Dyn. 241 583-94 PubMed GONUTS page

[PMID:20089884-7] Plante, I et al. (2010) Milk secretion and ejection are impaired in the mammary gland of mice harboring a Cx43 mutant while expression and localization of tight and adherens junction proteins remain unchanged. Biol. Reprod. 82 837-47 PubMed GONUTS page

[PMID:22946046-8] Guillemot, L et al. (2012) Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury. J. Cell. Sci. 125 5005-14 PubMed GONUTS page

[PMID:16520537-9] Ohta, H et al. (2006) Developmental changes in the expression of tight junction protein claudins in murine metanephroi and embryonic kidneys. J. Vet. Med. Sci. 68 149-55 PubMed GONUTS page

[PMID:15775979-10] 10.0 ^10.1 Tunggal, JA et al. (2005) E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J. 24 1146-56 PubMed GONUTS page

[PMID:12673830-11] Nico, B et al. (2003) Severe alterations of endothelial and glial cells in the blood-brain barrier of dystrophic mdx mice. Glia 42 235-51 PubMed GONUTS page

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MOUSE:CLD1

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