MOUSE:CEGT

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ugcg
Protein Name(s)	Ceramide glucosyltransferase GLCT-1 Glucosylceramide synthase GCS UDP-glucose ceramide glucosyltransferase UDP-glucose:N-acylsphingosine D-glucosyltransferase
External Links
UniProt	O88693
EMBL	AB012807 D89866 AL808112 CH466565 BC050828
CCDS	CCDS18219.1
RefSeq	NP_035803.1
UniGene	Mm.198803
ProteinModelPortal	O88693
BindingDB	O88693
ChEMBL	CHEMBL6013
CAZy	GT21
PhosphoSite	O88693
MaxQB	O88693
PRIDE	O88693
Ensembl	ENSMUST00000030074
GeneID	22234
KEGG	mmu:22234
UCSC	uc008szr.1
CTD	7357
MGI	MGI:1332243
eggNOG	COG1215
GeneTree	ENSGT00390000012898
HOGENOM	HOG000039663
HOVERGEN	HBG003997
InParanoid	O88693
KO	K00720
OMA	LVWICDS
OrthoDB	EOG70KGPR
PhylomeDB	O88693
TreeFam	TF314564
Reactome	REACT_199008
UniPathway	UPA00222
ChiTaRS	Ugcg
NextBio	302281
PRO	PR:O88693
Proteomes	UP000000589
Bgee	O88693
CleanEx	MM_UGCG
Genevestigator	O88693
GO	GO:0000139 GO:0016021 GO:0008120 GO:0006665
Gene3D	3.90.550.10
InterPro	IPR025993 IPR029044
Pfam	PF13506
SUPFAM	SSF53448

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0006497	protein lipidation	PMID:23748427^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006679	glucosylceramide biosynthetic process	PMID:23748427^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1903575	cornified envelope assembly	PMID:23748427^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030216	keratinocyte differentiation	PMID:23748427^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006679	glucosylceramide biosynthetic process	PMID:22851168^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0098856	intestinal lipid absorption	PMID:22851168^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0061436	establishment of skin barrier	PMID:17145749^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048666	neuron development	PMID:16109770^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006679	glucosylceramide biosynthetic process	PMID:16109770^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:10430909^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008120	ceramide glucosyltransferase activity	PMID:10430909^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006679	glucosylceramide biosynthetic process	PMID:10430909^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16739	C	Seeded From UniProt	complete
involved_in	GO:0033210	leptin-mediated signaling pathway	PMID:23554574^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009966	regulation of signal transduction	PMID:23554574^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008120	ceramide glucosyltransferase activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0067102 PANTHER:PTN000296098 RGD:621870	F	Seeded From UniProt	complete
involved_in	GO:0006679	glucosylceramide biosynthetic process	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000296098 UniProtKB:F4ITI0 WB:WBGene00011517 WB:WBGene00019127	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621870	C	Seeded From UniProt	complete
enables	GO:0008120	ceramide glucosyltransferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16739	F	Seeded From UniProt	complete
enables	GO:0008120	ceramide glucosyltransferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621870	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006679	glucosylceramide biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16739	P	Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16739	C	Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621870	C	Seeded From UniProt	complete
enables	GO:0008120	ceramide glucosyltransferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16739 ensembl:ENSP00000363397	F	Seeded From UniProt	complete
involved_in	GO:0006679	glucosylceramide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16739 ensembl:ENSP00000363397	P	Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16739 ensembl:ENSP00000363397	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0E0 ensembl:ENSRNOP00000021110	C	Seeded From UniProt	complete
enables	GO:0008120	ceramide glucosyltransferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0E0 ensembl:ENSRNOP00000021110	F	Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0E0 ensembl:ENSRNOP00000021110	C	Seeded From UniProt	complete
enables	GO:0016757	transferase activity, transferring glycosyl groups	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR025993	F	Seeded From UniProt	complete
enables	GO:0008120	ceramide glucosyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.4.1.80	F	Seeded From UniProt	complete
enables	GO:0102769	dihydroceramide glucosyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.4.1.80	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0006665	sphingolipid metabolic process	GO_REF:0000037 GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0746 UniPathway:UPA00222	P	Seeded From UniProt	complete
enables	GO:0016757	transferase activity, transferring glycosyl groups	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0328	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333	C	Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0134	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Amen, N et al. (2013) Differentiation of epidermal keratinocytes is dependent on glucosylceramide:ceramide processing. Hum. Mol. Genet. 22 4164-79 PubMed GONUTS page
↑ ^2.0 ^2.1 Jennemann, R et al. (2012) Glycosphingolipids are essential for intestinal endocytic function. J. Biol. Chem. 287 32598-616 PubMed GONUTS page
↑ Jennemann, R et al. (2007) Integrity and barrier function of the epidermis critically depend on glucosylceramide synthesis. J. Biol. Chem. 282 3083-94 PubMed GONUTS page
↑ ^4.0 ^4.1 Jennemann, R et al. (2005) Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birth. Proc. Natl. Acad. Sci. U.S.A. 102 12459-64 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Yamashita, T et al. (1999) A vital role for glycosphingolipid synthesis during development and differentiation. Proc. Natl. Acad. Sci. U.S.A. 96 9142-7 PubMed GONUTS page
↑ ^6.0 ^6.1 Nordström, V et al. (2013) Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis. PLoS Biol. 11 e1001506 PubMed GONUTS page
↑ ^7.0 ^7.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23748427-1] 1.0 ^1.1 ^1.2 ^1.3 Amen, N et al. (2013) Differentiation of epidermal keratinocytes is dependent on glucosylceramide:ceramide processing. Hum. Mol. Genet. 22 4164-79 PubMed GONUTS page

[PMID:22851168-2] 2.0 ^2.1 Jennemann, R et al. (2012) Glycosphingolipids are essential for intestinal endocytic function. J. Biol. Chem. 287 32598-616 PubMed GONUTS page

[PMID:17145749-3] Jennemann, R et al. (2007) Integrity and barrier function of the epidermis critically depend on glucosylceramide synthesis. J. Biol. Chem. 282 3083-94 PubMed GONUTS page

[PMID:16109770-4] 4.0 ^4.1 Jennemann, R et al. (2005) Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birth. Proc. Natl. Acad. Sci. U.S.A. 102 12459-64 PubMed GONUTS page

[PMID:10430909-5] 5.0 ^5.1 ^5.2 Yamashita, T et al. (1999) A vital role for glycosphingolipid synthesis during development and differentiation. Proc. Natl. Acad. Sci. U.S.A. 96 9142-7 PubMed GONUTS page

[PMID:23554574-6] 6.0 ^6.1 Nordström, V et al. (2013) Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis. PLoS Biol. 11 e1001506 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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MOUSE:CEGT

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