MOUSE:CCD40

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ccdc40 (synonyms: Lnks)
Protein Name(s)	Coiled-coil domain-containing protein 40 Protein links
External Links
UniProt	Q8BI79
EMBL	AK046971 AK054172 AL672140 AL672140 BC085159
CCDS	CCDS25712.1
RefSeq	NP_780639.1
UniGene	Mm.189885
ProteinModelPortal	Q8BI79
STRING	10090.ENSMUSP00000039463
PhosphoSite	Q8BI79
MaxQB	Q8BI79
PaxDb	Q8BI79
PRIDE	Q8BI79
Ensembl	ENSMUST00000035935 ENSMUST00000053440
GeneID	207607
KEGG	mmu:207607
UCSC	uc007mqc.1 uc007mqe.1
CTD	55036
MGI	MGI:2443893
eggNOG	NOG138528
GeneTree	ENSGT00440000035688
HOGENOM	HOG000111411
HOVERGEN	HBG095564
InParanoid	Q8BI79
OMA	TTQAEGQ
OrthoDB	EOG747PHC
PhylomeDB	Q8BI79
TreeFam	TF325559
NextBio	371975
PRO	PR:Q8BI79
Proteomes	UP000000589
Bgee	Q8BI79
CleanEx	MM_CCDC40
ExpressionAtlas	Q8BI79
Genevestigator	Q8BI79
GO	GO:0005929 GO:0005737 GO:0070286 GO:0003341 GO:0071907 GO:0071910 GO:0035469 GO:0060287 GO:0001947 GO:0030324 GO:0003356
InterPro	IPR013956
Pfam	PF08647

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0030324	lung development	PMID:21131974^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070286	axonemal dynein complex assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4G0X9	P	Seeded From UniProt	complete
involved_in	GO:0060287	epithelial cilium movement involved in determination of left/right asymmetry	PMID:21131974^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:21131974^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21131974^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0003341	cilium movement	PMID:21131974^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060287	epithelial cilium movement involved in determination of left/right asymmetry	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2443893 PANTHER:PTN000780552 UniProtKB:Q4G0X9 ZFIN:ZDB-GENE-060503-723	P	Seeded From UniProt	complete
involved_in	GO:0035082	axoneme assembly	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2443893 PANTHER:PTN000780552	P	Seeded From UniProt	complete
part_of	GO:0005930	axoneme	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000780552 UniProtKB:Q4G0X9	C	Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000417959 UniProtKB:Q4G0X9	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071910	determination of liver left/right asymmetry	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q4G0X9	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071907	determination of digestive tract left/right asymmetry	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q4G0X9	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070286	axonemal dynein complex assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q4G0X9	P	Seeded From UniProt	complete
involved_in	GO:0061512	protein localization to cilium	PMID:26387594^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3662904	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060287	epithelial cilium movement involved in determination of left/right asymmetry	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q4G0X9	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044458	motile cilium assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q4G0X9	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036159	inner dynein arm assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q4G0X9	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035469	determination of pancreatic left/right asymmetry	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q4G0X9	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035082	axoneme assembly	PMID:26387594^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3662904	P	Seeded From UniProt	complete
part_of	GO:0031514	motile cilium	PMID:26387594^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q4G0X9	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030317	flagellated sperm motility	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q4G0X9	P	Seeded From UniProt	complete
part_of	GO:0005930	axoneme	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q4G0X9	C	Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q4G0X9	C	Seeded From UniProt	complete
enables	GO:0003674	molecular_function	GO_REF:0000015	ECO:0000307	no biological data found used in manual assertion		F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003356	regulation of cilium beat frequency	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q4G0X9	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003351	epithelial cilium movement	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q4G0X9	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003341	cilium movement	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q4G0X9	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001947	heart looping	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q4G0X9	P	Seeded From UniProt	complete
involved_in	GO:0071910	determination of liver left/right asymmetry	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4G0X9 ensembl:ENSP00000380679	P	Seeded From UniProt	complete
involved_in	GO:0071907	determination of digestive tract left/right asymmetry	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4G0X9 ensembl:ENSP00000380679	P	Seeded From UniProt	complete
involved_in	GO:0070286	axonemal dynein complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4G0X9 ensembl:ENSP00000380679	P	Seeded From UniProt	complete
involved_in	GO:0060287	epithelial cilium movement involved in determination of left/right asymmetry	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4G0X9 ensembl:ENSP00000380679	P	Seeded From UniProt	complete
involved_in	GO:0044458	motile cilium assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4G0X9 ensembl:ENSP00000380679	P	Seeded From UniProt	complete
involved_in	GO:0036159	inner dynein arm assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4G0X9 ensembl:ENSP00000380679	P	Seeded From UniProt	complete
involved_in	GO:0035469	determination of pancreatic left/right asymmetry	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4G0X9 ensembl:ENSP00000380679	P	Seeded From UniProt	complete
involved_in	GO:0030324	lung development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4G0X9 ensembl:ENSP00000380679	P	Seeded From UniProt	complete
involved_in	GO:0030317	flagellated sperm motility	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4G0X9 ensembl:ENSP00000380679	P	Seeded From UniProt	complete
part_of	GO:0005930	axoneme	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4G0X9 ensembl:ENSP00000380679	C	Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4G0X9 ensembl:ENSP00000380679	C	Seeded From UniProt	complete
involved_in	GO:0003356	regulation of cilium beat frequency	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4G0X9 ensembl:ENSP00000380679	P	Seeded From UniProt	complete
involved_in	GO:0003351	epithelial cilium movement	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4G0X9 ensembl:ENSP00000380679	P	Seeded From UniProt	complete
involved_in	GO:0003341	cilium movement	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4G0X9 ensembl:ENSP00000380679	P	Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4G0X9 ensembl:ENSP00000380679	P	Seeded From UniProt	complete
involved_in	GO:0035082	axoneme assembly	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037386	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0969 UniProtKB-SubCell:SL-0066	C	Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Becker-Heck, A et al. (2011) The coiled-coil domain containing protein CCDC40 is essential for motile cilia function and left-right axis formation. Nat. Genet. 43 79-84 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Olbrich, H et al. (2015) Loss-of-Function GAS8 Mutations Cause Primary Ciliary Dyskinesia and Disrupt the Nexin-Dynein Regulatory Complex. Am. J. Hum. Genet. 97 546-54 PubMed GONUTS page

[PMID:21131974-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Becker-Heck, A et al. (2011) The coiled-coil domain containing protein CCDC40 is essential for motile cilia function and left-right axis formation. Nat. Genet. 43 79-84 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:26387594-3] 3.0 ^3.1 ^3.2 Olbrich, H et al. (2015) Loss-of-Function GAS8 Mutations Cause Primary Ciliary Dyskinesia and Disrupt the Nexin-Dynein Regulatory Complex. Am. J. Hum. Genet. 97 546-54 PubMed GONUTS page

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MOUSE:CCD40

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