MOUSE:CATS

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ctss (synonyms: Cats)
Protein Name(s)	Cathepsin S
External Links
UniProt	O70370
EMBL	AF051732 AF051727 AF051728 AF051729 AF051726 AF051730 AF051731 AF038546 AJ002386 AC092203 Y18466 AJ223208
CCDS	CCDS50992.1
RefSeq	NP_067256.4
UniGene	Mm.3619
PDB	1M0H 4BPV 4BQV 4BS5 4BS6 4BSQ 4MZO 4MZS
PDBsum	1M0H 4BPV 4BQV 4BS5 4BS6 4BSQ 4MZO 4MZS
ProteinModelPortal	O70370
SMR	O70370
BindingDB	O70370
ChEMBL	CHEMBL4098
MEROPS	C01.034
PhosphoSite	O70370
MaxQB	O70370
PaxDb	O70370
PRIDE	O70370
Ensembl	ENSMUST00000116304
GeneID	13040
KEGG	mmu:13040
UCSC	uc008qjz.2
CTD	1520
MGI	MGI:107341
eggNOG	COG4870
GeneTree	ENSGT00760000118871
HOVERGEN	HBG011513
InParanoid	O70370
KO	K01368
BRENDA	3.4.22.27
Reactome	REACT_196550 REACT_197101 REACT_198976 REACT_199046 REACT_199052 REACT_199112
ChiTaRS	Ctss
NextBio	282932
PRO	PR:O70370
Proteomes	UP000000589
Bgee	O70370
CleanEx	MM_CTSS
ExpressionAtlas	O70370
Genevestigator	O70370
GO	GO:0031905 GO:0005764 GO:0016020 GO:0008234 GO:0008233 GO:0034769 GO:0050729 GO:0006508 GO:0051603
InterPro	IPR025661 IPR000169 IPR025660 IPR013128 IPR000668 IPR013201
PANTHER	PTHR12411
Pfam	PF08246 PF00112
PRINTS	PR00705
SMART	SM00848 SM00645
PROSITE	PS00640 PS00139 PS00639

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:2001259	positive regulation of cation channel activity	PMID:22864553^[1]	ECO:0000314			P		Figure 9: Activation of ENaC (cation channel) by cathepsin-S.	complete CACAO 5193
involved_in	GO:2001259	positive regulation of cation channel activity	PMID:22864553^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051603	proteolysis involved in cellular protein catabolic process	PMID:22952693^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034769	basement membrane disassembly	PMID:22952693^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051603	proteolysis involved in cellular protein catabolic process	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107341 PANTHER:PTN000274640 UniProtKB:P07711 UniProtKB:P07858 UniProtKB:P25774 UniProtKB:P43235	P		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0013770 MGI:MGI:107341 MGI:MGI:1860262 MGI:MGI:88561 MGI:MGI:88564 PANTHER:PTN000274640 RGD:2445 RGD:2447 RGD:2448 RGD:61810 RGD:621509 UniProtKB:P07711 UniProtKB:P07858 UniProtKB:P09668 UniProtKB:P25774 UniProtKB:Q9UBR2 WB:WBGene00000786 dictyBase:DDB_G0279187	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0034229 FB:FBgn0034709 MGI:MGI:88564 PANTHER:PTN000274640 RGD:2447 RGD:61810 RGD:621509 RGD:708479 UniProtKB:P07711 UniProtKB:P07858 UniProtKB:P09668 UniProtKB:P25774 UniProtKB:P43235 UniProtKB:Q9UBR2	C		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0013770 FB:FBgn0030521 MGI:MGI:107285 MGI:MGI:107341 PANTHER:PTN000274640 RGD:2448 RGD:621509 TAIR:locus:2133402 TAIR:locus:2157712 TAIR:locus:2204873 TAIR:locus:505006093 UniProtKB:P07711 UniProtKB:P07858 UniProtKB:P09668 UniProtKB:P25774 UniProtKB:P43235 UniProtKB:Q8IIL0	F		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	PMID:15308097^[4]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001259	positive regulation of cation channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25774	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051930	regulation of sensory perception of pain	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621513	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051603	proteolysis involved in cellular protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25774	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050729	positive regulation of inflammatory response	PMID:12163455^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2676278	P	regulates_o_has_participant:(EMAPA:18812)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048002	antigen processing and presentation of peptide antigen	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25774	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045453	bone resorption	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621513	P		Seeded From UniProt	complete
enables	GO:0043394	proteoglycan binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25774	F		Seeded From UniProt	complete
enables	GO:0043236	laminin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25774	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25774	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034769	basement membrane disassembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25774	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030574	collagen catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25774	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016485	protein processing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25774	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:11854359^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010447	response to acidic pH	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25774	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621513	C		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621513	F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	PMID:11854359^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006508	proteolysis	PMID:11854359^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006508	proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25774	P		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:11854359^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25774	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25774	C		Seeded From UniProt	complete
enables	GO:0005518	collagen binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25774	F		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25774	F		Seeded From UniProt	complete
enables	GO:0001968	fibronectin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25774	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000668	P		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000668 InterPro:IPR013128	F		Seeded From UniProt	complete
part_of	GO:0031905	early endosome lumen	Reactome:R-NUL-1236960	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458 UniProtKB-SubCell:SL-0158	C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0788	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Haerteis, S et al. (2012) Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S. Pflugers Arch. 464 353-65 PubMed GONUTS page
↑ ^2.0 ^2.1 Sage, J et al. (2012) Cleavage of nidogen-1 by cathepsin S impairs its binding to basement membrane partners. PLoS ONE 7 e43494 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Shen, L et al. (2004) Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo. Immunity 21 155-65 PubMed GONUTS page
↑ Saegusa, K et al. (2002) Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity. J. Clin. Invest. 110 361-9 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Lankar, D et al. (2002) Dynamics of major histocompatibility complex class II compartments during B cell receptor-mediated cell activation. J. Exp. Med. 195 461-72 PubMed GONUTS page

[PMID:22864553-1] 1.0 ^1.1 Haerteis, S et al. (2012) Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S. Pflugers Arch. 464 353-65 PubMed GONUTS page

[PMID:22952693-2] 2.0 ^2.1 Sage, J et al. (2012) Cleavage of nidogen-1 by cathepsin S impairs its binding to basement membrane partners. PLoS ONE 7 e43494 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15308097-4] Shen, L et al. (2004) Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo. Immunity 21 155-65 PubMed GONUTS page

[PMID:12163455-5] Saegusa, K et al. (2002) Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity. J. Clin. Invest. 110 361-9 PubMed GONUTS page

[PMID:11854359-6] 6.0 ^6.1 ^6.2 ^6.3 Lankar, D et al. (2002) Dynamics of major histocompatibility complex class II compartments during B cell receptor-mediated cell activation. J. Exp. Med. 195 461-72 PubMed GONUTS page

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MOUSE:CATS

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