MOUSE:CATB

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ctsb
Protein Name(s)	Cathepsin B Cathepsin B1 Cathepsin B light chain Cathepsin B heavy chain
External Links
UniProt	P10605
EMBL	M65270 M65263 M65264 M65265 M65266 M65267 M65268 M65269 M14222 X54966 S69034 AK083393 AK147192 AK149884 AK151790 AK167361 BC006656
CCDS	CCDS27197.1
PIR	A38458
RefSeq	NP_031824.1
UniGene	Mm.236553
ProteinModelPortal	P10605
SMR	P10605
IntAct	P10605
MINT	MINT-4089890
BindingDB	P10605
ChEMBL	CHEMBL5187
PhosphoSite	P10605
SWISS-2DPAGE	P10605
MaxQB	P10605
PaxDb	P10605
PRIDE	P10605
Ensembl	ENSMUST00000006235
GeneID	13030
KEGG	mmu:13030
UCSC	uc007uhh.2
CTD	1508
MGI	MGI:88561
eggNOG	COG4870
GeneTree	ENSGT00760000118871
HOGENOM	HOG000241341
HOVERGEN	HBG003480
InParanoid	P10605
KO	K01363
OMA	CTGEGDT
OrthoDB	EOG7034HR
PhylomeDB	P10605
TreeFam	TF314576
BioCyc	MetaCyc:MONOMER-14810
BRENDA	3.4.22.1
Reactome	REACT_198976 REACT_199046 REACT_199055
ChiTaRS	Ctsb
NextBio	282900
PRO	PR:P10605
Proteomes	UP000000589
Bgee	P10605
CleanEx	MM_CTSB
Genevestigator	P10605
GO	GO:0005615 GO:0070062 GO:0005764 GO:0042470 GO:0005739 GO:0005730 GO:0048471 GO:0004197 GO:0097067 GO:0030574 GO:0046697 GO:0030855 GO:0051603 GO:0050790
InterPro	IPR025661 IPR000169 IPR025660 IPR013128 IPR000668 IPR015643 IPR012599
PANTHER	PTHR12411 PTHR12411:SF285
Pfam	PF00112 PF08127
PRINTS	PR00705
SMART	SM00645
PROSITE	PS00640 PS00139 PS00639

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0046718	viral entry into host cell	PMID:15831716^[1]	ECO:0000315			P		Fig. 1, murine CatB is an essential host factor for EboV GP-dependent entry.	complete CACAO 2056
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28071719^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0000006)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:22159717^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0002048)	Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:28835281^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:24006456^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	produced_by:(CL:0002548)	Seeded From UniProt	complete
involved_in	GO:0046718	viral entry into host cell	PMID:15831716^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051603	proteolysis involved in cellular protein catabolic process	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107341 PANTHER:PTN000274640 UniProtKB:P07711 UniProtKB:P07858 UniProtKB:P25774 UniProtKB:P43235	P		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0013770 MGI:MGI:107341 MGI:MGI:1860262 MGI:MGI:88561 MGI:MGI:88564 PANTHER:PTN000274640 RGD:2445 RGD:2447 RGD:2448 RGD:61810 RGD:621509 UniProtKB:P07711 UniProtKB:P07858 UniProtKB:P09668 UniProtKB:P25774 UniProtKB:Q9UBR2 WB:WBGene00000786 dictyBase:DDB_G0279187	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0034229 FB:FBgn0034709 MGI:MGI:88564 PANTHER:PTN000274640 RGD:2447 RGD:61810 RGD:621509 RGD:708479 UniProtKB:P07711 UniProtKB:P07858 UniProtKB:P09668 UniProtKB:P25774 UniProtKB:P43235 UniProtKB:Q9UBR2	C		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0013770 FB:FBgn0030521 MGI:MGI:107285 MGI:MGI:107341 PANTHER:PTN000274640 RGD:2448 RGD:621509 TAIR:locus:2133402 TAIR:locus:2157712 TAIR:locus:2204873 TAIR:locus:505006093 UniProtKB:P07711 UniProtKB:P07858 UniProtKB:P09668 UniProtKB:P25774 UniProtKB:P43235 UniProtKB:Q8IIL0	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060548	negative regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621509	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051603	proteolysis involved in cellular protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07858	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07858	C		Seeded From UniProt	complete
colocalizes_with	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621509	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046697	decidualization	PMID:9310336^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88564	P	has_participant:(EMAPA:16059)	Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621509	F		Seeded From UniProt	complete
enables	GO:0043621	protein self-association	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621509	F		Seeded From UniProt	complete
enables	GO:0043394	proteoglycan binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07858	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07858	C		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621509	C		Seeded From UniProt	complete
enables	GO:0042277	peptide binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621509	F		Seeded From UniProt	complete
enables	GO:0030984	kininogen binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621509	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030574	collagen catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07858	P		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621509	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621509	C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621509	C		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07858	F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07858	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006508	proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07858	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006508	proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621509	P		Seeded From UniProt	complete
colocalizes_with	GO:0005901	caveola	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621509	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:9034150^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07858	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621509	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:14651853^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846)\|part_of:(EMAPA:16894)\|part_of:(EMAPA:17373)\|part_of:(EMAPA:16105)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621509	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621509	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07858	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07858	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621509	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621509	C		Seeded From UniProt	complete
enables	GO:0005518	collagen binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07858	F		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07858	F		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621509	F		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621509	F		Seeded From UniProt	complete
involved_in	GO:0097067	cellular response to thyroid hormone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07858 ensembl:ENSP00000345672	P		Seeded From UniProt	complete
involved_in	GO:0051603	proteolysis involved in cellular protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07858 ensembl:ENSP00000345672	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07858 ensembl:ENSP00000345672	C		Seeded From UniProt	complete
enables	GO:0043394	proteoglycan binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07858 ensembl:ENSP00000345672	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07858 ensembl:ENSP00000345672	C		Seeded From UniProt	complete
involved_in	GO:0030855	epithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07858 ensembl:ENSP00000345672	P		Seeded From UniProt	complete
involved_in	GO:0030574	collagen catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07858 ensembl:ENSP00000345672	P		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07858 ensembl:ENSP00000345672	F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07858 ensembl:ENSP00000345672	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07858 ensembl:ENSP00000345672	P		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07858 ensembl:ENSP00000345672	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07858 ensembl:ENSP00000345672	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07858 ensembl:ENSP00000345672	C		Seeded From UniProt	complete
enables	GO:0005518	collagen binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07858 ensembl:ENSP00000345672	F		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07858 ensembl:ENSP00000345672	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R374 ensembl:ENSP00000345672	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R374 ensembl:ENSP00000345672	C		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012599	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000668	P		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000668 InterPro:IPR013128	F		Seeded From UniProt	complete
involved_in	GO:0050790	regulation of catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012599	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458 UniProtKB-SubCell:SL-0158	C		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0788	F		Seeded From UniProt	complete
part_of	GO:0042470	melanosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0161	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0112	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Chandran, K et al. (2005) Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection. Science 308 1643-5 PubMed GONUTS page
↑ Naba, A et al. (2017) Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep 7 40495 PubMed GONUTS page
↑ Naba, A et al. (2012) The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell Proteomics 11 M111.014647 PubMed GONUTS page
↑ Zhou, X et al. (2017) Lysosomal processing of progranulin. Mol Neurodegener 12 62 PubMed GONUTS page
↑ Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Afonso, S et al. (1997) The expression and function of cystatin C and cathepsin B and cathepsin L during mouse embryo implantation and placentation. Development 124 3415-25 PubMed GONUTS page
↑ Gruenheid, S et al. (1997) Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome. J. Exp. Med. 185 717-30 PubMed GONUTS page
↑ Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page

[PMID:15831716-1] 1.0 ^1.1 Chandran, K et al. (2005) Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection. Science 308 1643-5 PubMed GONUTS page

[PMID:28071719-2] Naba, A et al. (2017) Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep 7 40495 PubMed GONUTS page

[PMID:22159717-3] Naba, A et al. (2012) The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell Proteomics 11 M111.014647 PubMed GONUTS page

[PMID:28835281-4] Zhou, X et al. (2017) Lysosomal processing of progranulin. Mol Neurodegener 12 62 PubMed GONUTS page

[PMID:24006456-5] Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9310336-7] Afonso, S et al. (1997) The expression and function of cystatin C and cathepsin B and cathepsin L during mouse embryo implantation and placentation. Development 124 3415-25 PubMed GONUTS page

[PMID:9034150-8] Gruenheid, S et al. (1997) Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome. J. Exp. Med. 185 717-30 PubMed GONUTS page

[PMID:14651853-9] Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page

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MOUSE:CATB

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