MOUSE:CAN1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Capn1 (synonyms: Canp1, Capa1)
Protein Name(s)	Calpain-1 catalytic subunit Calcium-activated neutral proteinase 1 CANP 1 Calpain mu-type Calpain-1 large subunit Micromolar-calpain muCANP
External Links
UniProt	O35350
EMBL	AF021847 AF084459 BC026138
CCDS	CCDS37893.1
RefSeq	NP_001103974.1 NP_031626.1
UniGene	Mm.6221
ProteinModelPortal	O35350
SMR	O35350
BioGrid	198470
DIP	DIP-60303N
IntAct	O35350
MINT	MINT-4089782
MEROPS	C02.001
PhosphoSite	O35350
MaxQB	O35350
PaxDb	O35350
PRIDE	O35350
Ensembl	ENSMUST00000025891 ENSMUST00000164843
GeneID	12333
KEGG	mmu:12333
UCSC	uc008ggj.2
CTD	823
MGI	MGI:88263
eggNOG	NOG327523
HOGENOM	HOG000232035
HOVERGEN	HBG012645
InParanoid	O35350
KO	K01367
OMA	MEENDDH
OrthoDB	EOG7RV9FM
PhylomeDB	O35350
TreeFam	TF314748
Reactome	REACT_199052
NextBio	280940
PRO	PR:O35350
Proteomes	UP000000589
Bgee	O35350
CleanEx	MM_CAPN1
ExpressionAtlas	O35350
Genevestigator	O35350
GO	GO:0005737 GO:0005829 GO:0070062 GO:0005764 GO:0005739 GO:0005886 GO:0005509 GO:0004198 GO:0060056 GO:0006508 GO:0032801
Gene3D	1.10.238.10
InterPro	IPR022684 IPR022682 IPR022683 IPR029643 IPR011992 IPR018247 IPR002048 IPR000169 IPR001300
PANTHER	PTHR10183:SF284
Pfam	PF01067 PF00648
PRINTS	PR00704
SMART	SM00720 SM00230 SM00054
SUPFAM	SSF49758
PROSITE	PS50203 PS00018 PS50222 PS00139

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07384	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07384	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07384	F		Seeded From UniProt	complete
involved_in	GO:0097264	self proteolysis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07384	P		Seeded From UniProt	complete
involved_in	GO:0050790	regulation of catalytic activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07384	P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97571	P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0012051 FB:FBgn0025866 MGI:MGI:107437 MGI:MGI:88263 MGI:MGI:88264 PANTHER:PTN000021568 RGD:2267 RGD:2268 RGD:2269 RGD:69354 UniProtKB:P07384 UniProtKB:P20807 UniProtKB:P35750 UniProtKB:Q9HC96 WB:WBGene00006606	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0025866 FB:FBgn0260450 MGI:MGI:107437 MGI:MGI:88264 PANTHER:PTN000021568 RGD:2268 RGD:2269 RGD:69354 UniProtKB:P20807 UniProtKB:P35750 UniProtKB:Q8RVL2	C		Seeded From UniProt	complete
enables	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0012051 FB:FBgn0025866 MGI:MGI:107437 MGI:MGI:2181366 MGI:MGI:88263 PANTHER:PTN000021568 RGD:2267 RGD:2269 RGD:69354 UniProtKB:P07384 UniProtKB:P17655 UniProtKB:P35750 UniProtKB:Q9HC96	F		Seeded From UniProt	complete
enables	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0012051 FB:FBgn0025866 MGI:MGI:107437 MGI:MGI:2181366 MGI:MGI:88263 MGI:MGI:88264 PANTHER:PTN000021568 RGD:2267 RGD:2268 RGD:2269 RGD:69354 UniProtKB:P07384 UniProtKB:P17655 UniProtKB:P35750 UniProtKB:Q9HC96	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990776	response to angiotensin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2267	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903238	positive regulation of leukocyte tethering or rolling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2267	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901223	negative regulation of NIK/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2267	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097264	self proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07384	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2267	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060056	mammary gland involution	PMID:22555453^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050790	regulation of catalytic activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07384	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043117	positive regulation of vascular permeability	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2267	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032801	receptor catabolic process	PMID:17529984^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030837	negative regulation of actin filament polymerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2267	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2267	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016540	protein autoprocessing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2267	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07384	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2267	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2267	P		Seeded From UniProt	complete
enables	GO:0008092	cytoskeletal protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2267	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006508	proteolysis	PMID:22555453^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(MGI:MGI:96748) occurs_in:(EMAPA:17759)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006508	proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07384	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006508	proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2267	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07384	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:22555453^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17759)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07384	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2267	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:22555453^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17759)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:22555453^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17759)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2267	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07384	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2267	F		Seeded From UniProt	complete
enables	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	PMID:17529984^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	PMID:17646163^[4]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04632	F		Seeded From UniProt	complete
enables	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07384	F		Seeded From UniProt	complete
enables	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2267	F		Seeded From UniProt	complete
involved_in	GO:0097264	self proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07384 ensembl:ENSP00000431984	P		Seeded From UniProt	complete
involved_in	GO:0050790	regulation of catalytic activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07384 ensembl:ENSP00000431984	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07384 ensembl:ENSP00000431984	C		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07384 ensembl:ENSP00000431984	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07384 ensembl:ENSP00000431984	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07384 ensembl:ENSP00000431984	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07384 ensembl:ENSP00000431984	F		Seeded From UniProt	complete
enables	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07384 ensembl:ENSP00000431984	F		Seeded From UniProt	complete
enables	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001300 InterPro:IPR022684 InterPro:IPR029643	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002048 InterPro:IPR029643	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001300 InterPro:IPR022684 InterPro:IPR029643	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-MMU-8863416	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	PMID:10825211^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0788	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Arnandis, T et al. (2012) Calpains mediate epithelial-cell death during mammary gland involution: mitochondria and lysosomal destabilization. Cell Death Differ. 19 1536-48 PubMed GONUTS page
↑ ^3.0 ^3.1 Hawasli, AH et al. (2007) Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation. Nat. Neurosci. 10 880-6 PubMed GONUTS page
↑ Hata, S et al. (2007) Stomach-specific calpain, nCL-2/calpain 8, is active without calpain regulatory subunit and oligomerizes through C2-like domains. J. Biol. Chem. 282 27847-56 PubMed GONUTS page
↑ Arthur, JS et al. (2000) Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and division. Mol. Cell. Biol. 20 4474-81 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22555453-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Arnandis, T et al. (2012) Calpains mediate epithelial-cell death during mammary gland involution: mitochondria and lysosomal destabilization. Cell Death Differ. 19 1536-48 PubMed GONUTS page

[PMID:17529984-3] 3.0 ^3.1 Hawasli, AH et al. (2007) Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation. Nat. Neurosci. 10 880-6 PubMed GONUTS page

[PMID:17646163-4] Hata, S et al. (2007) Stomach-specific calpain, nCL-2/calpain 8, is active without calpain regulatory subunit and oligomerizes through C2-like domains. J. Biol. Chem. 282 27847-56 PubMed GONUTS page

[PMID:10825211-5] Arthur, JS et al. (2000) Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and division. Mol. Cell. Biol. 20 4474-81 PubMed GONUTS page

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MOUSE:CAN1

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