MOUSE:CAHM1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Calhm1
Protein Name(s)	Calcium homeostasis modulator protein 1
External Links
UniProt	D3Z291
EMBL	AC124724 CH466534
CCDS	CCDS38015.1
RefSeq	NP_001074740.1
UniGene	Mm.439624
STRING	10090.ENSMUSP00000107444
iPTMnet	D3Z291
PaxDb	D3Z291
PRIDE	D3Z291
Ensembl	ENSMUST00000111813
GeneID	546729
KEGG	mmu:546729
UCSC	uc008hus.1
CTD	255022
MGI	MGI:3643383
eggNOG	ENOG410IG7G ENOG410YNIM
GeneTree	ENSGT00530000062796
HOGENOM	HOG000111295
InParanoid	D3Z291
KO	K19738
OMA	MNNNVSM
OrthoDB	EOG70GMG1
PhylomeDB	D3Z291
TreeFam	TF329085
PRO	PR:D3Z291
Proteomes	UP000000589
GO	GO:0005789 GO:0005887 GO:0005227 GO:0042802 GO:0005245 GO:0005244 GO:0015867 GO:0006812 GO:0051260 GO:0034765 GO:0050913 GO:0050916 GO:0050909 GO:0050917
InterPro	IPR029568 IPR029569
PANTHER	PTHR32261 PTHR32261:SF2
Pfam	PF14798

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0050909	sensory perception of taste	PMID:23467090^[1]	ECO:0000315			P	Through work with CALHM1 knockout mutants,it was shown (FIG. 4) that CALHM1 is involved in the taste-evoked ATP release from taste cells.	complete CACAO 6938
	GO:0005245	voltage-gated calcium channel activity	PMID:22711817^[2]	ECO:0000314			F	Figures 1 and 4 in this publication shwo that CALHM1 is involved in voltage-dependent gating and that the channel works with calcium.	complete CACAO 6939
enables	GO:0005245	voltage-gated calcium channel activity	PMID:22711817^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0050909	sensory perception of taste	PMID:23467090^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8IU99	P	Seeded From UniProt	complete
involved_in	GO:0050917	sensory perception of umami taste	PMID:23467090^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050916	sensory perception of sweet taste	PMID:23467090^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050913	sensory perception of bitter taste	PMID:23467090^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034765	regulation of ion transmembrane transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8IU99	P	Seeded From UniProt	complete
involved_in	GO:0015867	ATP transport	PMID:23467090^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006812	cation transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8IU99	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8IU99	C	Seeded From UniProt	complete
enables	GO:0005244	voltage-gated ion channel activity	PMID:23467090^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005227	calcium activated cation channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8IU99	F	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001283759 UniProtKB:Q8IU99	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051260	protein homooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IU99	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IU99	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034765	regulation of ion transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IU99	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006812	cation transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IU99	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IU99	C	Seeded From UniProt	complete
enables	GO:0005244	voltage-gated ion channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IU99	F	Seeded From UniProt	complete
enables	GO:0005227	calcium activated cation channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IU99	F	Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IU99 ensembl:ENSP00000329926	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IU99 ensembl:ENSP00000329926	F	Seeded From UniProt	complete
involved_in	GO:0034765	regulation of ion transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IU99 ensembl:ENSP00000329926	P	Seeded From UniProt	complete
involved_in	GO:0006812	cation transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IU99 ensembl:ENSP00000329926	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IU99 ensembl:ENSP00000329926	C	Seeded From UniProt	complete
enables	GO:0005244	voltage-gated ion channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IU99 ensembl:ENSP00000329926	F	Seeded From UniProt	complete
enables	GO:0005227	calcium activated cation channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IU99 ensembl:ENSP00000329926	F	Seeded From UniProt	complete
enables	GO:0005227	calcium activated cation channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029568	F	Seeded From UniProt	complete
enables	GO:0005244	voltage-gated ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029568	F	Seeded From UniProt	complete
involved_in	GO:0006812	cation transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029568	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	P	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	F	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P	Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0109	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Taruno, A et al. (2013) CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes. Nature 495 223-6 PubMed GONUTS page
↑ ^2.0 ^2.1 Ma, Z et al. (2012) Calcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability. Proc. Natl. Acad. Sci. U.S.A. 109 E1963-71 PubMed GONUTS page
↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23467090-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Taruno, A et al. (2013) CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes. Nature 495 223-6 PubMed GONUTS page

[PMID:22711817-2] 2.0 ^2.1 Ma, Z et al. (2012) Calcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability. Proc. Natl. Acad. Sci. U.S.A. 109 E1963-71 PubMed GONUTS page

[PMID:21873635-3] Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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MOUSE:CAHM1

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