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MOUSE:CA2D2
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Cacna2d2 (synonyms: Kiaa0558) | |
| Protein Name(s) | Voltage-dependent calcium channel subunit alpha-2/delta-2
Protein ducky Voltage-gated calcium channel subunit alpha-2/delta-2 Voltage-dependent calcium channel subunit alpha-2-2 Voltage-dependent calcium channel subunit delta-2 | |
| External Links | ||
| UniProt | Q6PHS9 | |
| EMBL | AF247139 AF247141 AF247142 AY502107 AK044603 AK164143 AK161839 BC056389 BC158058 AB093246 AF169633 | |
| CCDS | CCDS52916.1 CCDS52917.1 CCDS72304.1 CCDS72305.1 | |
| RefSeq | NP_001167518.1 NP_001167519.1 NP_001167520.1 NP_001167521.1 NP_064659.2 | |
| UniGene | Mm.273084 | |
| ProteinModelPortal | Q6PHS9 | |
| IntAct | Q6PHS9 | |
| PhosphoSite | Q6PHS9 | |
| MaxQB | Q6PHS9 | |
| PaxDb | Q6PHS9 | |
| PRIDE | Q6PHS9 | |
| Ensembl | ENSMUST00000010210 ENSMUST00000085092 ENSMUST00000166799 ENSMUST00000168532 ENSMUST00000170737 | |
| GeneID | 56808 | |
| KEGG | mmu:56808 | |
| UCSC | uc009rli.2 uc009rlj.2 uc012haf.1 | |
| CTD | 9254 | |
| MGI | MGI:1929813 | |
| eggNOG | NOG307080 | |
| GeneTree | ENSGT00530000062904 | |
| HOVERGEN | HBG057779 | |
| InParanoid | Q6PHS9 | |
| KO | K04859 | |
| OrthoDB | EOG70GMDV | |
| PhylomeDB | Q6PHS9 | |
| TreeFam | TF315824 | |
| Reactome | REACT_263148 | |
| NextBio | 313361 | |
| PRO | PR:Q6PHS9 | |
| Proteomes | UP000000589 | |
| Bgee | Q6PHS9 | |
| ExpressionAtlas | Q6PHS9 | |
| Genevestigator | Q6PHS9 | |
| GO | GO:0005891 GO:0046872 GO:0005245 GO:0006816 GO:0048747 GO:0007528 GO:0046622 GO:0040014 GO:0060024 | |
| Gene3D | 3.40.50.410 | |
| InterPro | IPR004010 IPR013680 IPR013608 IPR002035 | |
| Pfam | PF02743 PF08473 PF00092 PF08399 | |
| SMART | SM00327 | |
| SUPFAM | SSF53300 | |
| PROSITE | PS50234 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0005891 |
voltage-gated calcium channel complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1929813 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005245 |
voltage-gated calcium channel activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1929813 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0060024 |
rhythmic synaptic transmission |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1856022 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0048747 |
muscle fiber development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1856022 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0046622 |
positive regulation of organ growth |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1856022 |
P |
regulates_o_occurs_in:(EMAPA:16894)|regulates_o_occurs_in:(EMAPA:17577) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0040014 |
regulation of multicellular organism growth |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1856022 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0008016 |
regulation of heart contraction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:631360 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0007528 |
neuromuscular junction development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1856022 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006816 |
calcium ion transport |
ECO:0000305 |
curator inference used in manual assertion |
GO:0005245 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006816 |
calcium ion transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:631360 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005891 |
voltage-gated calcium channel complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005245 |
voltage-gated calcium channel activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005245 |
voltage-gated calcium channel activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:631360 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006816 |
calcium ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005262 |
calcium channel activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005244 |
voltage-gated ion channel activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006811 |
ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034765 |
regulation of ion transmembrane transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070588 |
calcium ion transmembrane transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Walter, JT et al. (2006) Decreases in the precision of Purkinje cell pacemaking cause cerebellar dysfunction and ataxia. Nat. Neurosci. 9 389-97 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Kaja, S et al. (2007) Redundancy of Cav2.1 channel accessory subunits in transmitter release at the mouse neuromuscular junction. Brain Res. 1143 92-101 PubMed GONUTS page
- ↑ Holz, A et al. (1997) Chromosomal localization of the myelin-associated oligodendrocytic basic protein and expression in the genetically linked neurological mouse mutants ducky and tippy. J. Neurochem. 69 1801-9 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Barclay, J et al. (2001) Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells. J. Neurosci. 21 6095-104 PubMed GONUTS page
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