MOUSE:BMPR2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Bmpr2
Protein Name(s)	Bone morphogenetic protein receptor type-2 BMP type-2 receptor BMPR-2 BRK-3 Bone morphogenetic protein receptor type II BMP type II receptor BMPR-II
External Links
UniProt	O35607
EMBL	AF003942 U78048
CCDS	CCDS35588.1
PIR	JC5527
RefSeq	NP_031587.1
UniGene	Mm.391654 Mm.7106
ProteinModelPortal	O35607
SMR	O35607
BioGrid	198373
IntAct	O35607
MINT	MINT-1743993
PhosphoSite	O35607
MaxQB	O35607
PaxDb	O35607
PRIDE	O35607
DNASU	12168
Ensembl	ENSMUST00000087435
GeneID	12168
KEGG	mmu:12168
UCSC	uc007bdz.1
CTD	659
MGI	MGI:1095407
eggNOG	COG0515
GeneTree	ENSGT00760000118876
HOGENOM	HOG000043088
HOVERGEN	HBG050705
InParanoid	O35607
KO	K04671
OMA	DHYKPAI
OrthoDB	EOG7JHM5B
PhylomeDB	O35607
TreeFam	TF314724
BRENDA	2.7.10.2
Reactome	REACT_220505
NextBio	280539
PRO	PR:O35607
Proteomes	UP000000589
Bgee	O35607
ExpressionAtlas	O35607
Genevestigator	O35607
GO	GO:0016324 GO:0009925 GO:0005901 GO:0009986 GO:0005737 GO:0030425 GO:0005615 GO:0005887 GO:0043025 GO:0097481 GO:0005886 GO:0005524 GO:0046872 GO:0004702 GO:0005024 GO:0009952 GO:0060840 GO:0001974 GO:0030509 GO:0007420 GO:0009267 GO:0002063 GO:0060173 GO:0048286 GO:0001946 GO:0060836 GO:0001893 GO:0001707 GO:0030308 GO:1902731 GO:2000279 GO:0003085 GO:0045906 GO:0048842 GO:0030513 GO:0030501 GO:0010595 GO:0001938 GO:0045669 GO:0010862 GO:0014916 GO:0061298 GO:0006366 GO:0048010 GO:0060841
InterPro	IPR000472 IPR015770 IPR011009 IPR000719 IPR017441 IPR000333
PANTHER	PTHR23255 PTHR23255:SF63
Pfam	PF01064 PF00069
SUPFAM	SSF56112
PROSITE	PS00107 PS50011

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0003177	pulmonary valve development	PMID:12441304^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	GO:1905314	P		Seeded From UniProt	complete
involved_in	GO:0003176	aortic valve development	PMID:12441304^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	GO:1905314	P		Seeded From UniProt	complete
involved_in	GO:0060413	atrial septum morphogenesis	PMID:19409885^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0003181	atrioventricular valve morphogenesis	PMID:12441304^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:12441304^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q62009) occurs_in:(UBERON:0005967)	Seeded From UniProt	complete
involved_in	GO:0003197	endocardial cushion development	PMID:12441304^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061626	pharyngeal arch artery morphogenesis	PMID:12441304^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060412	ventricular septum morphogenesis	PMID:12441304^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003148	outflow tract septum morphogenesis	PMID:12441304^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045778	positive regulation of ossification	PMID:12441304^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003252	negative regulation of cell proliferation involved in heart valve morphogenesis	PMID:19409885^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0005623)	Seeded From UniProt	complete
involved_in	GO:1905314	semi-lunar valve development	PMID:19409885^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003186	tricuspid valve morphogenesis	PMID:19409885^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003183	mitral valve morphogenesis	PMID:19409885^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0048738	cardiac muscle tissue development	PMID:19409885^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0061626	pharyngeal arch artery morphogenesis	PMID:19409885^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0003148	outflow tract septum morphogenesis	PMID:19409885^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	PMID:19409885^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060412	ventricular septum morphogenesis	PMID:19409885^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1905314	semi-lunar valve development	PMID:12441304^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0098821	BMP receptor activity	PMID:26774823^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:26774823^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061036	positive regulation of cartilage development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F6RIN4	P		Seeded From UniProt	complete
involved_in	GO:0060350	endochondral bone morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F6RIN4	P		Seeded From UniProt	complete
involved_in	GO:0030166	proteoglycan biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F6RIN4	P		Seeded From UniProt	complete
involved_in	GO:0061036	positive regulation of cartilage development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O42124	P		Seeded From UniProt	complete
involved_in	GO:0060350	endochondral bone morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O42124	P		Seeded From UniProt	complete
involved_in	GO:0030166	proteoglycan biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O42124	P		Seeded From UniProt	complete
involved_in	GO:0048842	positive regulation of axon extension involved in axon guidance	PMID:24052814^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	UniProtKB:O35607	P	results_in_morphogenesis_of:(UBERON:0000348)	Seeded From UniProt	complete
involved_in	GO:0061298	retina vasculature development in camera-type eye	PMID:19903896^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060841	venous blood vessel development	PMID:19903896^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0061298)	Seeded From UniProt	complete
involved_in	GO:0060840	artery development	PMID:19903896^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0061298)	Seeded From UniProt	complete
involved_in	GO:0060836	lymphatic endothelial cell differentiation	PMID:19903896^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048286	lung alveolus development	PMID:18552156^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:18552156^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045906	negative regulation of vasoconstriction	PMID:18552156^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014916	regulation of lung blood pressure	PMID:18552156^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001974	blood vessel remodeling	PMID:19903896^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0061298)	Seeded From UniProt	complete
involved_in	GO:0001946	lymphangiogenesis	PMID:19903896^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0098821	BMP receptor activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1095407 PANTHER:PTN001147423	F		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 RGD:621789 UniProtKB:O00238 UniProtKB:P36894 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 UniProtKB:Q04771	F		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000583675 UniProtKB:P27037 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:P37173 UniProtKB:Q13705	C		Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102806 MGI:MGI:87911 MGI:MGI:87912 PANTHER:PTN000583675 RGD:71082 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:Q13705 UniProtKB:Q8NER5	F		Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338938 MGI:MGI:87912 PANTHER:PTN000583675	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003716 MGI:MGI:1338946 MGI:MGI:87911 MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 RGD:3852 RGD:620200 RGD:69651 RGD:70964 UniProtKB:A0A0B4KG59 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 UniProtKB:Q04771 UniProtKB:Q06900 UniProtKB:Q90ZK6	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN000583675 RGD:69651 RGD:70964 UniProtKB:P36896 UniProtKB:P37023 UniProtKB:Q04771 UniProtKB:Q13873	C		Seeded From UniProt	complete
enables	GO:0005026	transforming growth factor beta receptor activity, type II	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001147423 RGD:70964	F		Seeded From UniProt	complete
enables	GO:0005024	transforming growth factor beta-activated receptor activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 UniProtKB:A0A0B4KG59 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 ZFIN:ZDB-GENE-070618-1	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000279	negative regulation of DNA biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13873	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902731	negative regulation of chondrocyte proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13873	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072577	endothelial cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13873	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071773	cellular response to BMP stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13873	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060173	limb development	PMID:23610558^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2444521	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13873	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13873	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:71082	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13873	P		Seeded From UniProt	complete
enables	GO:0036122	BMP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13873	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030513	positive regulation of BMP signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13873	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	PMID:17472960^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000192)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13873	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030501	positive regulation of bone mineralization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13873	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:71082	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030308	negative regulation of cell growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13873	P		Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:71082	F		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:71082	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014916	regulation of lung blood pressure	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13873	P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:17114649^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13873	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010634	positive regulation of epithelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13873	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010595	positive regulation of endothelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13873	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:12117821^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:15542835^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:87912	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:10772805^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158503	P		Seeded From UniProt	complete
part_of	GO:0009925	basal plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:71082	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13873	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006366	transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13873	P		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13873	C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:71082	C		Seeded From UniProt	complete
colocalizes_with	GO:0005901	caveola	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13873	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13873	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:23676498^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000192) part_of:(EMAPA:29915)\|part_of:(CL:2000002)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13873	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:71082	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13873	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003085	negative regulation of systemic arterial blood pressure	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13873	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002063	chondrocyte development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13873	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13873	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001935	endothelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13873	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001893	maternal placenta development	PMID:23676498^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158503,MGI:MGI:3576366	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001707	mesoderm formation	PMID:10772805^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158503	P		Seeded From UniProt	complete
involved_in	GO:0060041	retina development in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LQC5 ensembl:ENSRNOP00000037011	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LQC5 ensembl:ENSRNOP00000037011	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LQC5 ensembl:ENSRNOP00000037011	C		Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LQC5 ensembl:ENSRNOP00000037011	F		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LQC5 ensembl:ENSRNOP00000037011	C		Seeded From UniProt	complete
part_of	GO:0009925	basal plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LQC5 ensembl:ENSRNOP00000037011	C		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LQC5 ensembl:ENSRNOP00000037011	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LQC5 ensembl:ENSRNOP00000037011	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LQC5 ensembl:ENSRNOP00000037011	C		Seeded From UniProt	complete
involved_in	GO:2000279	negative regulation of DNA biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P		Seeded From UniProt	complete
involved_in	GO:1902731	negative regulation of chondrocyte proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P		Seeded From UniProt	complete
involved_in	GO:0072577	endothelial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P		Seeded From UniProt	complete
involved_in	GO:0071773	cellular response to BMP stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P		Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P		Seeded From UniProt	complete
enables	GO:0036122	BMP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	F		Seeded From UniProt	complete
involved_in	GO:0030513	positive regulation of BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P		Seeded From UniProt	complete
involved_in	GO:0030501	positive regulation of bone mineralization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P		Seeded From UniProt	complete
involved_in	GO:0014916	regulation of lung blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P		Seeded From UniProt	complete
involved_in	GO:0010634	positive regulation of epithelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P		Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P		Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P		Seeded From UniProt	complete
involved_in	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	C		Seeded From UniProt	complete
involved_in	GO:0003085	negative regulation of systemic arterial blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P		Seeded From UniProt	complete
involved_in	GO:0002063	chondrocyte development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P		Seeded From UniProt	complete
involved_in	GO:0001935	endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	F		Seeded From UniProt	complete
enables	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000472	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	P		Seeded From UniProt	complete
involved_in	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000472	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Délot, EC et al. (2003) BMP signaling is required for septation of the outflow tract of the mammalian heart. Development 130 209-20 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Beppu, H et al. (2009) BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesis. Dev. Biol. 331 167-75 PubMed GONUTS page
↑ ^3.0 ^3.1 Indjeian, VB et al. (2016) Evolving New Skeletal Traits by cis-Regulatory Changes in Bone Morphogenetic Proteins. Cell 164 45-56 PubMed GONUTS page
↑ Engelhard, C et al. (2013) MEGF8 is a modifier of BMP signaling in trigeminal sensory neurons. Elife 2 e01160 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Niessen, K et al. (2010) ALK1 signaling regulates early postnatal lymphatic vessel development. Blood 115 1654-61 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Song, Y et al. (2008) Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice. Am. J. Physiol. Heart Circ. Physiol. 295 H677-90 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Kelly, CE et al. (2013) Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PLoS Biol. 11 e1001538 PubMed GONUTS page
↑ Xia, Y et al. (2007) Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. J. Biol. Chem. 282 18129-40 PubMed GONUTS page
↑ Munton, RP et al. (2007) Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol. Cell Proteomics 6 283-93 PubMed GONUTS page
↑ Faber, SC et al. (2002) Bmp signaling is required for development of primary lens fiber cells. Development 129 3727-37 PubMed GONUTS page
↑ Park, S et al. (2004) B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/smad signaling. Mol. Cell. Biol. 24 10256-62 PubMed GONUTS page
↑ ^13.0 ^13.1 Beppu, H et al. (2000) BMP type II receptor is required for gastrulation and early development of mouse embryos. Dev. Biol. 221 249-58 PubMed GONUTS page
↑ ^14.0 ^14.1 Nagashima, T et al. (2013) BMPR2 is required for postimplantation uterine function and pregnancy maintenance. J. Clin. Invest. 123 2539-50 PubMed GONUTS page

[PMID:12441304-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Délot, EC et al. (2003) BMP signaling is required for septation of the outflow tract of the mammalian heart. Development 130 209-20 PubMed GONUTS page

[PMID:19409885-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Beppu, H et al. (2009) BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesis. Dev. Biol. 331 167-75 PubMed GONUTS page

[PMID:26774823-3] 3.0 ^3.1 Indjeian, VB et al. (2016) Evolving New Skeletal Traits by cis-Regulatory Changes in Bone Morphogenetic Proteins. Cell 164 45-56 PubMed GONUTS page

[PMID:24052814-4] Engelhard, C et al. (2013) MEGF8 is a modifier of BMP signaling in trigeminal sensory neurons. Elife 2 e01160 PubMed GONUTS page

[PMID:19903896-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Niessen, K et al. (2010) ALK1 signaling regulates early postnatal lymphatic vessel development. Blood 115 1654-61 PubMed GONUTS page

[PMID:18552156-6] 6.0 ^6.1 ^6.2 ^6.3 Song, Y et al. (2008) Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice. Am. J. Physiol. Heart Circ. Physiol. 295 H677-90 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23610558-8] Kelly, CE et al. (2013) Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PLoS Biol. 11 e1001538 PubMed GONUTS page

[PMID:17472960-9] Xia, Y et al. (2007) Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. J. Biol. Chem. 282 18129-40 PubMed GONUTS page

[PMID:17114649-10] Munton, RP et al. (2007) Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol. Cell Proteomics 6 283-93 PubMed GONUTS page

[PMID:12117821-11] Faber, SC et al. (2002) Bmp signaling is required for development of primary lens fiber cells. Development 129 3727-37 PubMed GONUTS page

[PMID:15542835-12] Park, S et al. (2004) B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/smad signaling. Mol. Cell. Biol. 24 10256-62 PubMed GONUTS page

[PMID:10772805-13] 13.0 ^13.1 Beppu, H et al. (2000) BMP type II receptor is required for gastrulation and early development of mouse embryos. Dev. Biol. 221 249-58 PubMed GONUTS page

[PMID:23676498-14] 14.0 ^14.1 Nagashima, T et al. (2013) BMPR2 is required for postimplantation uterine function and pregnancy maintenance. J. Clin. Invest. 123 2539-50 PubMed GONUTS page

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MOUSE:BMPR2

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