MOUSE:BAKOR

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Atg14 (synonyms: D14Ertd436e, Kiaa0831)
Protein Name(s)	Beclin 1-associated autophagy-related key regulator Barkor Autophagy-related protein 14-like protein Atg14L
External Links
UniProt	Q8CDJ3
EMBL	AK029967 AK054196 BC025038 BC057360 BC090995 AK173037
CCDS	CCDS26989.1
RefSeq	NP_766187.1
UniGene	Mm.287279 Mm.470462
ProteinModelPortal	Q8CDJ3
DIP	DIP-60849N
IntAct	Q8CDJ3
PhosphoSite	Q8CDJ3
PaxDb	Q8CDJ3
PRIDE	Q8CDJ3
Ensembl	ENSMUST00000042988
GeneID	100504663
KEGG	mmu:100504663
UCSC	uc007tik.2
CTD	22863
MGI	MGI:1261775
eggNOG	NOG236057
GeneTree	ENSGT00390000011854
HOGENOM	HOG000045344
HOVERGEN	HBG081828
InParanoid	Q8CDJ3
KO	K17889
OMA	CVQSGDF
OrthoDB	EOG7SV0WR
PhylomeDB	Q8CDJ3
TreeFam	TF323392
NextBio	33367523
PRO	PR:Q8CDJ3
Proteomes	UP000000589
Bgee	Q8CDJ3
CleanEx	MM_D14ERTD436E
Genevestigator	Q8CDJ3
GO	GO:0005776 GO:0005930 GO:0044233 GO:0005634 GO:0045335 GO:0034045 GO:0000045 GO:0006914 GO:0008333 GO:0010508 GO:0090207
InterPro	IPR018791
Pfam	PF10186

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0006914	autophagy	PMID:19270693^[1]	ECO:0000315			P		As shown in Figure 2a, knockdown of Atg14L leads to a buildup of autophagy substrates that accumulate only in the event of autophagy impairment, as opposed to the wild type where the substrate levels are negligible.	complete CACAO 9054
involved_in	GO:0006914	autophagy	PMID:19270693^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035032	phosphatidylinositol 3-kinase complex, class III	PMID:23332761^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	PMID:23332761^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:23332761^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042149	cellular response to glucose starvation	PMID:23332761^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	PMID:19270696^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005930	axoneme	PMID:24089209^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0097632	extrinsic component of phagophore assembly site membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001784663 UniProtKB:Q6ZNE5	C		Seeded From UniProt	complete
part_of	GO:0097629	extrinsic component of omegasome membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001784663 UniProtKB:Q6ZNE5	C		Seeded From UniProt	complete
part_of	GO:0044233	mitochondria-associated endoplasmic reticulum membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1261775 PANTHER:PTN001784663	C		Seeded From UniProt	complete
involved_in	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001784663 UniProtKB:Q6ZNE5	P		Seeded From UniProt	complete
part_of	GO:0035032	phosphatidylinositol 3-kinase complex, class III	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1261775 PANTHER:PTN001784663	C		Seeded From UniProt	complete
part_of	GO:0034045	phagophore assembly site membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001784663 UniProtKB:Q6ZNE5	C		Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001784663 UniProtKB:Q6ZNE5	P		Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001784663 UniProtKB:Q6ZNE5	C		Seeded From UniProt	complete
involved_in	GO:0000423	mitophagy	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001784663 UniProtKB:Q6ZNE5	P		Seeded From UniProt	complete
involved_in	GO:0000045	autophagosome assembly	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001784663 UniProtKB:Q6ZNE5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098780	response to mitochondrial depolarisation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ZNE5	P		Seeded From UniProt	complete
part_of	GO:0097632	extrinsic component of phagophore assembly site membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ZNE5	C		Seeded From UniProt	complete
part_of	GO:0097629	extrinsic component of omegasome membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ZNE5	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090207	regulation of triglyceride metabolic process	PMID:22992773^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
enables	GO:0051020	GTPase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ZNE5	F		Seeded From UniProt	complete
part_of	GO:0045335	phagocytic vesicle	PMID:22493499^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0044233	mitochondria-associated endoplasmic reticulum membrane	PMID:23455425^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ZNE5	P		Seeded From UniProt	complete
part_of	GO:0034045	phagophore assembly site membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ZNE5	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016240	autophagosome membrane docking	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ZNE5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016236	macroautophagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ZNE5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010608	posttranscriptional regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ZNE5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009267	cellular response to starvation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ZNE5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008333	endosome to lysosome transport	PMID:22797916^[9]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ZNE5	P		Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ZNE5	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001932	regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ZNE5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000423	mitophagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ZNE5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000045	autophagosome assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ZNE5	P		Seeded From UniProt	complete
involved_in	GO:0098780	response to mitochondrial depolarisation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZNE5 ensembl:ENSP00000247178	P		Seeded From UniProt	complete
part_of	GO:0097632	extrinsic component of phagophore assembly site membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZNE5 ensembl:ENSP00000247178	C		Seeded From UniProt	complete
part_of	GO:0097629	extrinsic component of omegasome membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZNE5 ensembl:ENSP00000247178	C		Seeded From UniProt	complete
enables	GO:0051020	GTPase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZNE5 ensembl:ENSP00000247178	F		Seeded From UniProt	complete
involved_in	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZNE5 ensembl:ENSP00000247178	P		Seeded From UniProt	complete
part_of	GO:0034045	phagophore assembly site membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZNE5 ensembl:ENSP00000247178	C		Seeded From UniProt	complete
involved_in	GO:0016240	autophagosome membrane docking	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZNE5 ensembl:ENSP00000247178	P		Seeded From UniProt	complete
involved_in	GO:0016236	macroautophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZNE5 ensembl:ENSP00000247178	P		Seeded From UniProt	complete
involved_in	GO:0010608	posttranscriptional regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZNE5 ensembl:ENSP00000247178	P		Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZNE5 ensembl:ENSP00000247178	P		Seeded From UniProt	complete
involved_in	GO:0008333	endosome to lysosome transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZNE5 ensembl:ENSP00000247178	P		Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZNE5 ensembl:ENSP00000247178	C		Seeded From UniProt	complete
involved_in	GO:0001932	regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZNE5 ensembl:ENSP00000247178	P		Seeded From UniProt	complete
involved_in	GO:0000423	mitophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZNE5 ensembl:ENSP00000247178	P		Seeded From UniProt	complete
involved_in	GO:0000045	autophagosome assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZNE5 ensembl:ENSP00000247178	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0072	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0000421	autophagosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0022	C		Seeded From UniProt	complete
part_of	GO:0034045	phagophore assembly site membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0221	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Zhong, Y et al. (2009) Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat. Cell Biol. 11 468-76 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Kim, J et al. (2013) Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell 152 290-303 PubMed GONUTS page
↑ Matsunaga, K et al. (2009) Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat. Cell Biol. 11 385-96 PubMed GONUTS page
↑ Pampliega, O et al. (2013) Functional interaction between autophagy and ciliogenesis. Nature 502 194-200 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Xiong, X et al. (2012) The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolism. J. Biol. Chem. 287 39107-14 PubMed GONUTS page
↑ Ma, C et al. (2012) Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex. J. Biol. Chem. 287 18359-65 PubMed GONUTS page
↑ Hamasaki, M et al. (2013) Autophagosomes form at ER-mitochondria contact sites. Nature 495 389-93 PubMed GONUTS page
↑ Kim, HJ et al. (2012) Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking. J. Cell. Sci. 125 4740-50 PubMed GONUTS page

[PMID:19270693-1] 1.0 ^1.1 Zhong, Y et al. (2009) Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat. Cell Biol. 11 468-76 PubMed GONUTS page

[PMID:23332761-2] 2.0 ^2.1 ^2.2 ^2.3 Kim, J et al. (2013) Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell 152 290-303 PubMed GONUTS page

[PMID:19270696-3] Matsunaga, K et al. (2009) Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat. Cell Biol. 11 385-96 PubMed GONUTS page

[PMID:24089209-4] Pampliega, O et al. (2013) Functional interaction between autophagy and ciliogenesis. Nature 502 194-200 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22992773-6] Xiong, X et al. (2012) The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolism. J. Biol. Chem. 287 39107-14 PubMed GONUTS page

[PMID:22493499-7] Ma, C et al. (2012) Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex. J. Biol. Chem. 287 18359-65 PubMed GONUTS page

[PMID:23455425-8] Hamasaki, M et al. (2013) Autophagosomes form at ER-mitochondria contact sites. Nature 495 389-93 PubMed GONUTS page

[PMID:22797916-9] Kim, HJ et al. (2012) Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking. J. Cell. Sci. 125 4740-50 PubMed GONUTS page

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MOUSE:BAKOR

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