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MOUSE:AZI1
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Azi1 (synonyms: Az1, Azi) | |
| Protein Name(s) | 5-azacytidine-induced protein 1
Pre-acrosome localization protein 1 | |
| External Links | ||
| UniProt | Q62036 | |
| EMBL | D43921 D88509 AL807824 | |
| PIR | S63993 | |
| RefSeq | NP_033864.3 XP_006532124.1 | |
| UniGene | Mm.2556 | |
| BioGrid | 198290 | |
| IntAct | Q62036 | |
| MINT | MINT-4088912 | |
| STRING | 10090.ENSMUSP00000101836 | |
| PhosphoSite | Q62036 | |
| MaxQB | Q62036 | |
| PaxDb | Q62036 | |
| PRIDE | Q62036 | |
| Ensembl | ENSMUST00000106229 | |
| GeneID | 12009 | |
| KEGG | mmu:12009 | |
| CTD | 22994 | |
| MGI | MGI:107440 | |
| eggNOG | NOG77550 | |
| GeneTree | ENSGT00390000001758 | |
| HOGENOM | HOG000293266 | |
| HOVERGEN | HBG024371 | |
| InParanoid | B1AXJ0 | |
| KO | K16540 | |
| OMA | RFIQQVN | |
| NextBio | 280207 | |
| PRO | PR:Q62036 | |
| ArrayExpress | Q62036 | |
| Bgee | Q62036 | |
| CleanEx | MM_AZI1 | |
| Genevestigator | Q62036 | |
| GO | GO:0030154 GO:0007275 GO:0007283 | |
| InterPro | IPR000048 | |
| SMART | SM00015 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0044441 |
ciliary part |
ECO:0000315 |
C |
According to figure 4a, depletion of AZI1 reduced cilia formation by approximately 50%. Therefore, the azi1 gene positively influences cilia formation. |
complete | |||||
|
involved_in |
GO:0090316 |
positive regulation of intracellular protein transport |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035735 |
intraciliary transport involved in cilium assembly |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0044877 |
protein-containing complex binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0034451 |
centriolar satellite |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010824 |
regulation of centrosome duplication |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005813 |
centrosome |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060271 |
cilium assembly |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0033447 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0034451 |
centriolar satellite |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:107440 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010824 |
regulation of centrosome duplication |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001267958 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1990953 |
intramanchette transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3870375 |
P |
|
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:1905515 |
non-motile cilium assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0000057) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1905198 |
manchette assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3870375 |
P |
|
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0090316 |
positive regulation of intracellular protein transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071539 |
protein localization to centrosome |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045171 |
intercellular bridge |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0044877 |
protein-containing complex binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042073 |
intraciliary transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3870375 |
P |
occurs_in:(EMAPA:17972)|occurs_in:(EMAPA:19292) |
Seeded From UniProt |
complete | |
|
part_of |
GO:0035869 |
ciliary transition zone |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000057) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0035869 |
ciliary transition zone |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0035735 |
intraciliary transport involved in cilium assembly |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0034451 |
centriolar satellite |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000057) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0034451 |
centriolar satellite |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0015630 |
microtubule cytoskeleton |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010824 |
regulation of centrosome duplication |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007288 |
sperm axoneme assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3870375 |
P |
occurs_in:(EMAPA:17972)|occurs_in:(EMAPA:19292) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0007286 |
spermatid development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3870375 |
P |
occurs_in:(EMAPA:17972) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0007286 |
spermatid development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
occurs_in:(CL:0000018) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005815 |
microtubule organizing center |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005813 |
centrosome |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0005813 |
centrosome |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0001669 |
acrosomal vesicle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0002177 |
manchette |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:1990953 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035735 |
intraciliary transport involved in cilium assembly |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007283 |
spermatogenesis |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007283 |
spermatogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030030 |
cell projection organization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007049 |
cell cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0001669 |
acrosomal vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005815 |
microtubule organizing center |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Chamling, X et al. (2014) The centriolar satellite protein AZI1 interacts with BBS4 and regulates ciliary trafficking of the BBSome. PLoS Genet. 10 e1004083 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 Hall, EA et al. (2013) Acute versus chronic loss of mammalian Azi1/Cep131 results in distinct ciliary phenotypes. PLoS Genet. 9 e1003928 PubMed GONUTS page
- ↑ Aoto, H et al. (1995) Isolation of a novel cDNA that encodes a protein localized to the pre-acrosome region of spermatids. Eur. J. Biochem. 234 8-15 PubMed GONUTS page
- ↑ Aoto, H et al. (1997) Genomic organization of the mouse AZ1 gene that encodes the protein localized to preacrosomes of spermatids. Genomics 40 138-41 PubMed GONUTS page
c
- GO:0007049 ! cell cycle
- GO:0030154 ! cell differentiation
- GO:0042995 ! cell projection
- GO:0030030 ! cell projection organization
- GO:0034451 ! centriolar satellite
- GO:0005813 ! centrosome
- Chordata
- GO:0035869 ! ciliary transition zone
- GO:0060271 ! cilium assembly
- Craniata
- GO:0005737 ! cytoplasm
- GO:0031410 ! cytoplasmic vesicle
- GO:0005856 ! cytoskeleton
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