MOUSE:AT132

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Atp13a2
Protein Name(s)	Probable cation-transporting ATPase 13A2
External Links
UniProt	Q9CTG6
EMBL	AL645625 BC042661 AK003623
CCDS	CCDS18859.1
RefSeq	NP_083373.2
UniGene	Mm.205625
ProteinModelPortal	Q9CTG6
SMR	Q9CTG6
MINT	MINT-4998039
STRING	10090.ENSMUSP00000039648
PhosphoSite	Q9CTG6
MaxQB	Q9CTG6
PaxDb	Q9CTG6
PRIDE	Q9CTG6
Ensembl	ENSMUST00000037055
GeneID	74772
KEGG	mmu:74772
UCSC	uc008vnn.2
CTD	23400
MGI	MGI:1922022
eggNOG	COG0474
GeneTree	ENSGT00530000063001
HOGENOM	HOG000171813
HOVERGEN	HBG065757
InParanoid	Q9CTG6
KO	K13526
OMA	WQLFTVQ
TreeFam	TF300331
ChiTaRS	Atp13a2
NextBio	341604
PRO	PR:Q9CTG6
Proteomes	UP000000589
Bgee	Q9CTG6
CleanEx	MM_ATP13A2
ExpressionAtlas	Q9CTG6
Genevestigator	Q9CTG6
GO	GO:0016021 GO:0005765 GO:0005764 GO:0005524 GO:0019829 GO:0046872
Gene3D	2.70.150.10 3.40.1110.10 3.40.50.1000
InterPro	IPR004014 IPR023299 IPR018303 IPR008250 IPR023214 IPR006544 IPR001757
Pfam	PF00122 PF12409
PRINTS	PR00119 PR00120
SMART	SM00831
SUPFAM	SSF56784 SSF81660
TIGRFAMs	TIGR01494 TIGR01657
PROSITE	PS00154

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0012506	vesicle membrane	PMID:22186024^[1]	ECO:0000314			C		mouse ATP13A2 is shown to localize to vesicle membranes within the soma and processes of cortical neurons (Fig. 2A)	complete CACAO 3711
involved_in	GO:0033157	regulation of intracellular protein transport	PMID:24334770^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P	has_regulation_target:(UniProtKB:P17439)	Seeded From UniProt	complete
involved_in	GO:1905123	regulation of glucosylceramidase activity	PMID:24334770^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0002609) regulates_o_occurs_in:(GO:0005764)	Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	PMID:24334770^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002609)	Seeded From UniProt	complete
involved_in	GO:1905165	regulation of lysosomal protein catabolic process	PMID:24334770^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055069	zinc ion homeostasis	PMID:24334770^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002609)	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:22186024^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002609)	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:22186024^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002609)	Seeded From UniProt	complete
part_of	GO:0012506	vesicle membrane	PMID:22186024^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002609) part_of:(GO:0043025)\|part_of:(CL:0002609) part_of:(GO:0043005)	Seeded From UniProt	complete
involved_in	GO:1903543	positive regulation of exosomal secretion	PMID:25392495^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010821	regulation of mitochondrion organization	PMID:22198378^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0012506	vesicle membrane	PMID:22186024^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NQ11	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990938	peptidyl-aspartic acid autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NQ11	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905165	regulation of lysosomal protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NQ11	P		Seeded From UniProt	complete
part_of	GO:1905103	integral component of lysosomal membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NQ11	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905037	autophagosome organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NQ11	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903543	positive regulation of exosomal secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NQ11	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902047	polyamine transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NQ11	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097734	extracellular exosome biogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NQ11	P		Seeded From UniProt	complete
enables	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NQ11	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071287	cellular response to manganese ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NQ11	P		Seeded From UniProt	complete
enables	GO:0070300	phosphatidic acid binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NQ11	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055069	zinc ion homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NQ11	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0052548	regulation of endopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NQ11	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050714	positive regulation of protein secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NQ11	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NQ11	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NQ11	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034599	cellular response to oxidative stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NQ11	P		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NQ11	C		Seeded From UniProt	complete
part_of	GO:0030133	transport vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NQ11	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016243	regulation of autophagosome size	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NQ11	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016243	regulation of autophagosome size	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307977	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016241	regulation of macroautophagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NQ11	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010821	regulation of mitochondrion organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NQ11	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010821	regulation of mitochondrion organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307977	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006882	cellular zinc ion homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NQ11	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006879	cellular iron ion homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NQ11	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NQ11	P		Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NQ11	C		Seeded From UniProt	complete
part_of	GO:0005771	multivesicular body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NQ11	C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NQ11	C		Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NQ11	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NQ11	C		Seeded From UniProt	complete
involved_in	GO:0016243	regulation of autophagosome size	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAA4 ensembl:ENSRNOP00000010884	P		Seeded From UniProt	complete
involved_in	GO:0010821	regulation of mitochondrion organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAA4 ensembl:ENSRNOP00000010884	P		Seeded From UniProt	complete
involved_in	GO:1990938	peptidyl-aspartic acid autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NQ11 ensembl:ENSP00000327214	P		Seeded From UniProt	complete
involved_in	GO:1905165	regulation of lysosomal protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NQ11 ensembl:ENSP00000327214	P		Seeded From UniProt	complete
part_of	GO:1905103	integral component of lysosomal membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NQ11 ensembl:ENSP00000327214	C		Seeded From UniProt	complete
involved_in	GO:1905037	autophagosome organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NQ11 ensembl:ENSP00000327214	P		Seeded From UniProt	complete
involved_in	GO:1903543	positive regulation of exosomal secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NQ11 ensembl:ENSP00000327214	P		Seeded From UniProt	complete
involved_in	GO:1902047	polyamine transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NQ11 ensembl:ENSP00000327214	P		Seeded From UniProt	complete
involved_in	GO:0097734	extracellular exosome biogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NQ11 ensembl:ENSP00000327214	P		Seeded From UniProt	complete
enables	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NQ11 ensembl:ENSP00000327214	F		Seeded From UniProt	complete
involved_in	GO:0071287	cellular response to manganese ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NQ11 ensembl:ENSP00000327214	P		Seeded From UniProt	complete
enables	GO:0070300	phosphatidic acid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NQ11 ensembl:ENSP00000327214	F		Seeded From UniProt	complete
involved_in	GO:0055069	zinc ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NQ11 ensembl:ENSP00000327214	P		Seeded From UniProt	complete
involved_in	GO:0052548	regulation of endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NQ11 ensembl:ENSP00000327214	P		Seeded From UniProt	complete
involved_in	GO:0050714	positive regulation of protein secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NQ11 ensembl:ENSP00000327214	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NQ11 ensembl:ENSP00000327214	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NQ11 ensembl:ENSP00000327214	C		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NQ11 ensembl:ENSP00000327214	P		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NQ11 ensembl:ENSP00000327214	C		Seeded From UniProt	complete
part_of	GO:0030133	transport vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NQ11 ensembl:ENSP00000327214	C		Seeded From UniProt	complete
involved_in	GO:0016243	regulation of autophagosome size	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NQ11 ensembl:ENSP00000327214	P		Seeded From UniProt	complete
involved_in	GO:0016241	regulation of macroautophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NQ11 ensembl:ENSP00000327214	P		Seeded From UniProt	complete
involved_in	GO:0010821	regulation of mitochondrion organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NQ11 ensembl:ENSP00000327214	P		Seeded From UniProt	complete
involved_in	GO:0006882	cellular zinc ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NQ11 ensembl:ENSP00000327214	P		Seeded From UniProt	complete
involved_in	GO:0006879	cellular iron ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NQ11 ensembl:ENSP00000327214	P		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NQ11 ensembl:ENSP00000327214	P		Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NQ11 ensembl:ENSP00000327214	C		Seeded From UniProt	complete
part_of	GO:0005771	multivesicular body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NQ11 ensembl:ENSP00000327214	C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NQ11 ensembl:ENSP00000327214	C		Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NQ11 ensembl:ENSP00000327214	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NQ11 ensembl:ENSP00000327214	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR023299	F		Seeded From UniProt	complete
involved_in	GO:0006812	cation transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006544	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001757 InterPro:IPR006544	C		Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006544	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458 UniProtKB-SubCell:SL-0158	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0157	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Ramonet, D et al. (2012) PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity. Hum. Mol. Genet. 21 1725-43 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Tsunemi, T & Krainc, D (2014) Zn²⁺ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation. Hum. Mol. Genet. 23 2791-801 PubMed GONUTS page
↑ Tsunemi, T et al. (2014) ATP13A2/PARK9 regulates secretion of exosomes and α-synuclein. J. Neurosci. 34 15281-7 PubMed GONUTS page
↑ Gusdon, AM et al. (2012) ATP13A2 regulates mitochondrial bioenergetics through macroautophagy. Neurobiol. Dis. 45 962-72 PubMed GONUTS page

[PMID:22186024-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Ramonet, D et al. (2012) PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity. Hum. Mol. Genet. 21 1725-43 PubMed GONUTS page

[PMID:24334770-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Tsunemi, T & Krainc, D (2014) Zn²⁺ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation. Hum. Mol. Genet. 23 2791-801 PubMed GONUTS page

[PMID:25392495-3] Tsunemi, T et al. (2014) ATP13A2/PARK9 regulates secretion of exosomes and α-synuclein. J. Neurosci. 34 15281-7 PubMed GONUTS page

[PMID:22198378-4] Gusdon, AM et al. (2012) ATP13A2 regulates mitochondrial bioenergetics through macroautophagy. Neurobiol. Dis. 45 962-72 PubMed GONUTS page

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MOUSE:AT132

Contents

Annotations

Notes

References

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