MOUSE:AS3MT

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	As3mt (synonyms: Cyt19)
Protein Name(s)	Arsenite methyltransferase Methylarsonite methyltransferase S-adenosyl-L-methionine:arsenic(III) methyltransferase
External Links
UniProt	Q91WU5
EMBL	AF166383 AC161865 BC145663 BC013468
CCDS	CCDS50458.1
PIR	T44795
RefSeq	NP_065602.2
UniGene	Mm.28566
ProteinModelPortal	Q91WU5
SMR	Q91WU5
BioGrid	208264
PhosphoSite	Q91WU5
MaxQB	Q91WU5
PaxDb	Q91WU5
PRIDE	Q91WU5
Ensembl	ENSMUST00000003655
GeneID	57344
KEGG	mmu:57344
UCSC	uc008huc.1
CTD	57412
MGI	MGI:1929882
eggNOG	NOG257055
GeneTree	ENSGT00390000001742
HOGENOM	HOG000229966
HOVERGEN	HBG050585
InParanoid	Q91WU5
KO	K07755
OMA	DIVVSNC
OrthoDB	EOG7V49ZQ
TreeFam	TF343797
NextBio	313710
PRO	PR:Q91WU5
Proteomes	UP000000589
Bgee	Q91WU5
CleanEx	MM_AS3MT
Genevestigator	Q91WU5
GO	GO:0005829 GO:0005739 GO:0030791 GO:0030792 GO:0018872 GO:0046685 GO:0009404
Gene3D	3.40.50.150
InterPro	IPR026669 IPR025714 IPR029063
PANTHER	PTHR10108:SF11
Pfam	PF13847
SUPFAM	SSF53335

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0050922	negative regulation of chemotaxis	PMID:23152186^[1]	ECO:0000314			P	Fig 2. As(III) causes concentration dependent inhibition of hMSC differentiation to adipocytes.	complete CACAO 6133
	GO:0045444	fat cell differentiation	PMID:23152186^[1]	ECO:0000315			P	Fig 3. As(III) must be present early to inhibit adipocyte differentiation.	complete CACAO 6134
enables	GO:0030792	methylarsonite methyltransferase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8VHT6	F	Seeded From UniProt	complete
enables	GO:0030791	arsenite methyltransferase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8VHT6	F	Seeded From UniProt	complete
involved_in	GO:0018872	arsonoacetate metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8VHT6	P	Seeded From UniProt	complete
involved_in	GO:0009404	toxin metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8VHT6	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8VHT6	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046685	response to arsenic-containing substance	PMID:15276411^[2]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8VHT6	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046685	response to arsenic-containing substance	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8VHT6	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032259	methylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HBK9	P	Seeded From UniProt	complete
enables	GO:0030792	methylarsonite methyltransferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HBK9	F	Seeded From UniProt	complete
enables	GO:0030792	methylarsonite methyltransferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621325	F	Seeded From UniProt	complete
enables	GO:0030791	arsenite methyltransferase activity	PMID:15276411^[2]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8VHT6	F	Seeded From UniProt	complete
enables	GO:0030791	arsenite methyltransferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HBK9	F	Seeded From UniProt	complete
enables	GO:0030791	arsenite methyltransferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621325	F	Seeded From UniProt	complete
enables	GO:0030791	arsenite methyltransferase activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8VHT6	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018872	arsonoacetate metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HBK9	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018872	arsonoacetate metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621325	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009404	toxin metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HBK9	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009404	toxin metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621325	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621325	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8VHT6	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:18614015^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0032259	methylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBK9 ensembl:ENSP00000358896	P	Seeded From UniProt	complete
enables	GO:0030792	methylarsonite methyltransferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBK9 ensembl:ENSP00000358896	F	Seeded From UniProt	complete
enables	GO:0030791	arsenite methyltransferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBK9 ensembl:ENSP00000358896	F	Seeded From UniProt	complete
involved_in	GO:0018872	arsonoacetate metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBK9 ensembl:ENSP00000358896	P	Seeded From UniProt	complete
involved_in	GO:0009404	toxin metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBK9 ensembl:ENSP00000358896	P	Seeded From UniProt	complete
enables	GO:0030791	arsenite methyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.1.1.137	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	F	Seeded From UniProt	complete
involved_in	GO:0032259	methylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Klei, LR et al. (2013) Arsenic activates endothelin-1 Gi protein-coupled receptor signaling to inhibit stem cell differentiation in adipogenesis. Toxicol. Sci. 131 512-20 PubMed GONUTS page
↑ ^2.0 ^2.1 Thomas, DJ et al. (2004) Elucidating the pathway for arsenic methylation. Toxicol. Appl. Pharmacol. 198 319-26 PubMed GONUTS page
↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page

[PMID:23152186-1] 1.0 ^1.1 Klei, LR et al. (2013) Arsenic activates endothelin-1 Gi protein-coupled receptor signaling to inhibit stem cell differentiation in adipogenesis. Toxicol. Sci. 131 512-20 PubMed GONUTS page

[PMID:15276411-2] 2.0 ^2.1 Thomas, DJ et al. (2004) Elucidating the pathway for arsenic methylation. Toxicol. Appl. Pharmacol. 198 319-26 PubMed GONUTS page

[PMID:18614015-3] Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page

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MOUSE:AS3MT

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