MOUSE:AR13B

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Arl13b (synonyms: Arl2l1)
Protein Name(s)	ADP-ribosylation factor-like protein 13B ADP-ribosylation factor-like protein 2-like 1 ARL2-like protein 1 Protein hennin
External Links
UniProt	Q640N2
EMBL	AC154309 CH466521 BC082574
CCDS	CCDS28261.1
RefSeq	NP_080853.3
UniGene	Mm.96833
ProteinModelPortal	Q640N2
SMR	Q640N2
PhosphoSite	Q640N2
PRIDE	Q640N2
Ensembl	ENSMUST00000089289
GeneID	68146
KEGG	mmu:68146
UCSC	uc007zpu.2
CTD	200894
MGI	MGI:1915396
eggNOG	COG1100
GeneTree	ENSGT00550000074639
HOGENOM	HOG000034031
HOVERGEN	HBG060221
InParanoid	Q640N2
KO	K07962
OMA	INLRQGK
OrthoDB	EOG7FNC7K
TreeFam	TF105476
ChiTaRS	Arl13b
NextBio	326526
PRO	PR:Q640N2
Proteomes	UP000000589
CleanEx	MM_ARL13B
ExpressionAtlas	Q640N2
Genevestigator	Q640N2
GO	GO:0060170 GO:0005929 GO:0005622 GO:0072372 GO:0005525 GO:0042384 GO:0007368 GO:0009953 GO:0021943 GO:0001947 GO:0021830 GO:0070986 GO:0021532 GO:0035058 GO:0007264 GO:0007224
Gene3D	3.40.50.300
InterPro	IPR027417 IPR005225 IPR024156 IPR006689
Pfam	PF00025
PRINTS	PR00328
SUPFAM	SSF52540
TIGRFAMs	TIGR00231
PROSITE	PS51417

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005930	axoneme	PMID:21209331^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Fig 4A shows ciliary localisation in WT	complete CACAO 2901
part_of	GO:0005930	axoneme	PMID:21209331^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:21209331^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:23153492^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0060170	ciliary membrane	PMID:21976698^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0060170	ciliary membrane	PMID:23817546^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:17488627^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1905515	non-motile cilium assembly	PMID:21976698^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021943	formation of radial glial scaffolds	PMID:23817546^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021830	interneuron migration from the subpallium to the cortex	PMID:23153492^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021532	neural tube patterning	PMID:23014696^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	PMID:17488627^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	PMID:21976698^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:17488627^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1905515	non-motile cilium assembly	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1915396 PANTHER:PTN000746458 WB:WBGene00021349	P		Seeded From UniProt	complete
part_of	GO:0097730	non-motile cilium	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000746458 WB:WBGene00021349	C		Seeded From UniProt	complete
involved_in	GO:0097500	receptor localization to non-motile cilium	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000746458 WB:WBGene00021349	P		Seeded From UniProt	complete
part_of	GO:0060170	ciliary membrane	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1915396 PANTHER:PTN000746458 WB:WBGene00021349	C		Seeded From UniProt	complete
part_of	GO:0031514	motile cilium	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1915396 PANTHER:PTN000918160	C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1915396 PANTHER:PTN000746458 UniProtKB:Q3SXY8 WB:WBGene00021349 ZFIN:ZDB-GENE-021217-3	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070986	left/right axis specification	PMID:22554696^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3578151	P	occurs_in:(EMAPA:16105)\|occurs_in:(EMAPA:16728)\|occurs_in:(EMAPA:17021)	Seeded From UniProt	complete
part_of	GO:0031514	motile cilium	PMID:24336288^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18984)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009953	dorsal/ventral pattern formation	PMID:15755804^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3578151	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007368	determination of left/right symmetry	PMID:15755804^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3578151	P	has_participant:(EMAPA:16039)	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:24336288^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:23351563^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32684)	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:22689656^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16530)	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:22179047^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17577)	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:20159594^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16164)	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:24421332^[15]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q3SXY8	C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q3SXY8	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001947	heart looping	PMID:22554696^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3578151	P	occurs_in:(EMAPA:16105)	Seeded From UniProt	complete
involved_in	GO:0010226	response to lithium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:M0RDU9 ensembl:ENSRNOP00000067810	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3SXY8 ensembl:ENSP00000377769	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005225 InterPro:IPR006689	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0969 UniProtKB-SubCell:SL-0066	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0342	F		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0060170	ciliary membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0305	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Qin, J et al. (2011) Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc. Natl. Acad. Sci. U.S.A. 108 1456-61 PubMed GONUTS page
↑ ^2.0 ^2.1 Higginbotham, H et al. (2012) Arl13b in primary cilia regulates the migration and placement of interneurons in the developing cerebral cortex. Dev. Cell 23 925-38 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Larkins, CE et al. (2011) Arl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteins. Mol. Biol. Cell 22 4694-703 PubMed GONUTS page
↑ ^4.0 ^4.1 Higginbotham, H et al. (2013) Arl13b-regulated cilia activities are essential for polarized radial glial scaffold formation. Nat. Neurosci. 16 1000-7 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Caspary, T et al. (2007) The graded response to Sonic Hedgehog depends on cilia architecture. Dev. Cell 12 767-78 PubMed GONUTS page
↑ Su, CY et al. (2012) Temporal deletion of Arl13b reveals that a mispatterned neural tube corrects cell fate over time. Development 139 4062-71 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^8.0 ^8.1 Larkins, CE et al. (2012) Defective Nodal and Cerl2 expression in the Arl13b(hnn) mutant node underlie its heterotaxia. Dev. Biol. 367 15-24 PubMed GONUTS page
↑ ^9.0 ^9.1 Delling, M et al. (2013) Primary cilia are specialized calcium signalling organelles. Nature 504 311-4 PubMed GONUTS page
↑ ^10.0 ^10.1 García-García, MJ et al. (2005) Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc. Natl. Acad. Sci. U.S.A. 102 5913-9 PubMed GONUTS page
↑ Pasek, RC et al. (2012) Mammalian Clusterin associated protein 1 is an evolutionarily conserved protein required for ciliogenesis. Cilia 1 20 PubMed GONUTS page
↑ Liem, KF Jr et al. (2012) The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking. J. Cell Biol. 197 789-800 PubMed GONUTS page
↑ Chih, B et al. (2012) A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain. Nat. Cell Biol. 14 61-72 PubMed GONUTS page
↑ Ko, HW et al. (2010) Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction. Dev. Cell 18 237-47 PubMed GONUTS page
↑ Kobayashi, T et al. (2014) The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly. J. Cell Biol. 204 215-29 PubMed GONUTS page

[PMID:21209331-1] 1.0 ^1.1 ^1.2 Qin, J et al. (2011) Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc. Natl. Acad. Sci. U.S.A. 108 1456-61 PubMed GONUTS page

[PMID:23153492-2] 2.0 ^2.1 Higginbotham, H et al. (2012) Arl13b in primary cilia regulates the migration and placement of interneurons in the developing cerebral cortex. Dev. Cell 23 925-38 PubMed GONUTS page

[PMID:21976698-3] 3.0 ^3.1 ^3.2 Larkins, CE et al. (2011) Arl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteins. Mol. Biol. Cell 22 4694-703 PubMed GONUTS page

[PMID:23817546-4] 4.0 ^4.1 Higginbotham, H et al. (2013) Arl13b-regulated cilia activities are essential for polarized radial glial scaffold formation. Nat. Neurosci. 16 1000-7 PubMed GONUTS page

[PMID:17488627-5] 5.0 ^5.1 ^5.2 Caspary, T et al. (2007) The graded response to Sonic Hedgehog depends on cilia architecture. Dev. Cell 12 767-78 PubMed GONUTS page

[PMID:23014696-6] Su, CY et al. (2012) Temporal deletion of Arl13b reveals that a mispatterned neural tube corrects cell fate over time. Development 139 4062-71 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22554696-8] 8.0 ^8.1 Larkins, CE et al. (2012) Defective Nodal and Cerl2 expression in the Arl13b(hnn) mutant node underlie its heterotaxia. Dev. Biol. 367 15-24 PubMed GONUTS page

[PMID:24336288-9] 9.0 ^9.1 Delling, M et al. (2013) Primary cilia are specialized calcium signalling organelles. Nature 504 311-4 PubMed GONUTS page

[PMID:15755804-10] 10.0 ^10.1 García-García, MJ et al. (2005) Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc. Natl. Acad. Sci. U.S.A. 102 5913-9 PubMed GONUTS page

[PMID:23351563-11] Pasek, RC et al. (2012) Mammalian Clusterin associated protein 1 is an evolutionarily conserved protein required for ciliogenesis. Cilia 1 20 PubMed GONUTS page

[PMID:22689656-12] Liem, KF Jr et al. (2012) The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking. J. Cell Biol. 197 789-800 PubMed GONUTS page

[PMID:22179047-13] Chih, B et al. (2012) A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain. Nat. Cell Biol. 14 61-72 PubMed GONUTS page

[PMID:20159594-14] Ko, HW et al. (2010) Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction. Dev. Cell 18 237-47 PubMed GONUTS page

[PMID:24421332-15] Kobayashi, T et al. (2014) The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly. J. Cell Biol. 204 215-29 PubMed GONUTS page

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MOUSE:AR13B

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