MOUSE:ANO1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ano1 (synonyms: Tmem16a)
Protein Name(s)	Anoctamin-1 Transmembrane protein 16A
External Links
UniProt	Q8BHY3
EMBL	AK028991 AK029329 AK052589 BC006062 BC062959
RefSeq	NP_001229278.1 NP_848757.4
UniGene	Mm.26700
ProteinModelPortal	Q8BHY3
SMR	Q8BHY3
STRING	10090.ENSMUSP00000113899
iPTMnet	Q8BHY3
EPD	Q8BHY3
MaxQB	Q8BHY3
PaxDb	Q8BHY3
PRIDE	Q8BHY3
Ensembl	ENSMUST00000033393
GeneID	101772
KEGG	mmu:101772
CTD	55107
MGI	MGI:2142149
eggNOG	KOG2514 ENOG410XS4S
GeneTree	ENSGT00760000119015
HOGENOM	HOG000006509
HOVERGEN	HBG069519
InParanoid	Q8BHY3
KO	K19496
OrthoDB	EOG7BS48W
PhylomeDB	Q8BHY3
Reactome	[www.reactome.org/content/detail/R-MMU-2672351 R-MMU-2672351]
PRO	PR:Q8BHY3
Proteomes	UP000000589
Bgee	Q8BHY3
ExpressionAtlas	Q8BHY3
Genevisible	Q8BHY3
GO	GO:0016324 GO:0034707 GO:0005737 GO:0009897 GO:0070062 GO:0005886 GO:0005227 GO:0005254 GO:0005229 GO:0015111 GO:0046982 GO:0042803 GO:0005247 GO:0098655 GO:0006812 GO:0034605 GO:1902476 GO:0006821 GO:0050965 GO:0015705 GO:0007200 GO:0035774 GO:1903959 GO:0042391 GO:0060438
InterPro	IPR032394 IPR007632 IPR031287
PANTHER	PTHR12308 PTHR12308:SF13
Pfam	PF16178 PF04547

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0005254	chloride channel activity	PMID:24885604^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(CL:0000169)	Seeded From UniProt	complete
involved_in	GO:1902476	chloride transmembrane transport	PMID:24885604^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000169)	Seeded From UniProt	complete
involved_in	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	PMID:24885604^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000169)	Seeded From UniProt	complete
NOT\|involved_in	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	PMID:22634729^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	PMID:22634729^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	PMID:22634729^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q704Y3	P		Seeded From UniProt	complete
enables	GO:0005247	voltage-gated chloride channel activity	PMID:22634729^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	PMID:22634729^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	causally_upstream_of:(GO:0005229) occurs_in:(CL:1001451)	Seeded From UniProt	complete
involved_in	GO:1902476	chloride transmembrane transport	PMID:22634729^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0034605) occurs_in:(CL:1001451)	Seeded From UniProt	complete
enables	GO:0005229	intracellular calcium activated chloride channel activity	PMID:22634729^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	part_of:(GO:0034605) occurs_in:(CL:1001451)	Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	PMID:22634729^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	causally_upstream_of:(GO:0005229) occurs_in:(CL:1001451)	Seeded From UniProt	complete
involved_in	GO:0060438	trachea development	PMID:18585372^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006821	chloride transport	PMID:18724360^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:22075693^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18585372^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005229	intracellular calcium activated chloride channel activity	PMID:22075693^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005229	intracellular calcium activated chloride channel activity	PMID:18724360^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902476	chloride transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5XXA6	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:23576756^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8CFW1	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:23576756^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8BHY3	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042391	regulation of membrane potential	PMID:23133519^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1918361	P	occurs_in:(EMAPA:32834)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042391	regulation of membrane potential	PMID:23133519^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:32834)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5XXA6	P		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:21516098^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35613) part_of:(CL:1001573)	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5XXA6	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015705	iodide transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5XXA6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015705	iodide transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1310786	P		Seeded From UniProt	complete
enables	GO:0015111	iodide transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5XXA6	F		Seeded From UniProt	complete
enables	GO:0015111	iodide transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1310786	F		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:23576756^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006821	chloride transport	PMID:23532839^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002404)\|occurs_in:(CL:0000578)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006821	chloride transport	PMID:20056604^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006821	chloride transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5XXA6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006821	chloride transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1310786	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006812	cation transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5XXA6	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:20056604^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5XXA6	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1310786	C		Seeded From UniProt	complete
enables	GO:0005254	chloride channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5XXA6	F		Seeded From UniProt	complete
enables	GO:0005229	intracellular calcium activated chloride channel activity	PMID:23576756^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005229	intracellular calcium activated chloride channel activity	PMID:23532839^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0002404)\|occurs_in:(CL:0000578)	Seeded From UniProt	complete
enables	GO:0005229	intracellular calcium activated chloride channel activity	PMID:20056604^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005229	intracellular calcium activated chloride channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5XXA6	F		Seeded From UniProt	complete
enables	GO:0005229	intracellular calcium activated chloride channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1310786	F		Seeded From UniProt	complete
enables	GO:0005227	calcium activated cation channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5XXA6	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031287	C		Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031287	P		Seeded From UniProt	complete
involved_in	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031287	P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032394	F		Seeded From UniProt	complete
involved_in	GO:1902476	chloride transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031287	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0034707	chloride channel complex	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0869	C		Seeded From UniProt	complete
enables	GO:0005254	chloride channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0869	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0006821	chloride transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0869	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Edlund, A et al. (2014) CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells. BMC Med 12 87 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Cho, H et al. (2012) The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. Nat. Neurosci. 15 1015-21 PubMed GONUTS page
↑ ^3.0 ^3.1 Rock, JR et al. (2008) The transmembrane protein TMEM16A is required for normal development of the murine trachea. Dev. Biol. 321 141-9 PubMed GONUTS page
↑ ^4.0 ^4.1 Yang, YD et al. (2008) TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature 455 1210-5 PubMed GONUTS page
↑ ^5.0 ^5.1 Duran, C et al. (2012) ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins. Am. J. Physiol., Cell Physiol. 302 C482-93 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Tien, J et al. (2013) Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC). Proc. Natl. Acad. Sci. U.S.A. 110 6352-7 PubMed GONUTS page
↑ ^7.0 ^7.1 Zeng, F et al. (2012) GPR39 is coupled to TMEM16A in intestinal fibroblast-like cells. PLoS ONE 7 e47686 PubMed GONUTS page
↑ Billig, GM et al. (2011) Ca2+-activated Cl− currents are dispensable for olfaction. Nat. Neurosci. 14 763-9 PubMed GONUTS page
↑ ^9.0 ^9.1 Suzuki, J et al. (2013) Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members. J. Biol. Chem. 288 13305-16 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Schreiber, R et al. (2010) Expression and function of epithelial anoctamins. J. Biol. Chem. 285 7838-45 PubMed GONUTS page

[PMID:24885604-1] 1.0 ^1.1 ^1.2 Edlund, A et al. (2014) CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells. BMC Med 12 87 PubMed GONUTS page

[PMID:22634729-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Cho, H et al. (2012) The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. Nat. Neurosci. 15 1015-21 PubMed GONUTS page

[PMID:18585372-3] 3.0 ^3.1 Rock, JR et al. (2008) The transmembrane protein TMEM16A is required for normal development of the murine trachea. Dev. Biol. 321 141-9 PubMed GONUTS page

[PMID:18724360-4] 4.0 ^4.1 Yang, YD et al. (2008) TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature 455 1210-5 PubMed GONUTS page

[PMID:22075693-5] 5.0 ^5.1 Duran, C et al. (2012) ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins. Am. J. Physiol., Cell Physiol. 302 C482-93 PubMed GONUTS page

[PMID:23576756-6] 6.0 ^6.1 ^6.2 ^6.3 Tien, J et al. (2013) Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC). Proc. Natl. Acad. Sci. U.S.A. 110 6352-7 PubMed GONUTS page

[PMID:23133519-7] 7.0 ^7.1 Zeng, F et al. (2012) GPR39 is coupled to TMEM16A in intestinal fibroblast-like cells. PLoS ONE 7 e47686 PubMed GONUTS page

[PMID:21516098-8] Billig, GM et al. (2011) Ca2+-activated Cl− currents are dispensable for olfaction. Nat. Neurosci. 14 763-9 PubMed GONUTS page

[PMID:23532839-9] 9.0 ^9.1 Suzuki, J et al. (2013) Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members. J. Biol. Chem. 288 13305-16 PubMed GONUTS page

[PMID:20056604-10] 10.0 ^10.1 ^10.2 Schreiber, R et al. (2010) Expression and function of epithelial anoctamins. J. Biol. Chem. 285 7838-45 PubMed GONUTS page

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MOUSE:ANO1

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