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MOUSE:ANO1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Ano1 (synonyms: Tmem16a)
Protein Name(s) Anoctamin-1

Transmembrane protein 16A

External Links
UniProt Q8BHY3
EMBL AK028991
AK029329
AK052589
BC006062
BC062959
RefSeq NP_001229278.1
NP_848757.4
UniGene Mm.26700
ProteinModelPortal Q8BHY3
SMR Q8BHY3
STRING 10090.ENSMUSP00000113899
iPTMnet Q8BHY3
EPD Q8BHY3
MaxQB Q8BHY3
PaxDb Q8BHY3
PRIDE Q8BHY3
Ensembl ENSMUST00000033393
GeneID 101772
KEGG mmu:101772
CTD 55107
MGI MGI:2142149
eggNOG KOG2514
ENOG410XS4S
GeneTree ENSGT00760000119015
HOGENOM HOG000006509
HOVERGEN HBG069519
InParanoid Q8BHY3
KO K19496
OrthoDB EOG7BS48W
PhylomeDB Q8BHY3
Reactome [www.reactome.org/content/detail/R-MMU-2672351 R-MMU-2672351]
PRO PR:Q8BHY3
Proteomes UP000000589
Bgee Q8BHY3
ExpressionAtlas Q8BHY3
Genevisible Q8BHY3
GO GO:0016324
GO:0034707
GO:0005737
GO:0009897
GO:0070062
GO:0005886
GO:0005227
GO:0005254
GO:0005229
GO:0015111
GO:0046982
GO:0042803
GO:0005247
GO:0098655
GO:0006812
GO:0034605
GO:1902476
GO:0006821
GO:0050965
GO:0015705
GO:0007200
GO:0035774
GO:1903959
GO:0042391
GO:0060438
InterPro IPR032394
IPR007632
IPR031287
PANTHER PTHR12308
PTHR12308:SF13
Pfam PF16178
PF04547

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0005254

chloride channel activity

PMID:24885604[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

occurs_in:(CL:0000169)

Seeded From UniProt

complete

involved_in

GO:1902476

chloride transmembrane transport

PMID:24885604[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0000169)

Seeded From UniProt

complete

involved_in

GO:0035774

positive regulation of insulin secretion involved in cellular response to glucose stimulus

PMID:24885604[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0000169)

Seeded From UniProt

complete

NOT|involved_in

GO:0050966

detection of mechanical stimulus involved in sensory perception of pain

PMID:22634729[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050965

detection of temperature stimulus involved in sensory perception of pain

PMID:22634729[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050965

detection of temperature stimulus involved in sensory perception of pain

PMID:22634729[2]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q704Y3

P

Seeded From UniProt

complete

enables

GO:0005247

voltage-gated chloride channel activity

PMID:22634729[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007200

phospholipase C-activating G protein-coupled receptor signaling pathway

PMID:22634729[2]

ECO:0000314

direct assay evidence used in manual assertion

P

  • causally_upstream_of:(GO:0005229)
  • occurs_in:(CL:1001451)

Seeded From UniProt

complete

involved_in

GO:1902476

chloride transmembrane transport

PMID:22634729[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005229

intracellular calcium activated chloride channel activity

PMID:22634729[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0034605

cellular response to heat

PMID:22634729[2]

ECO:0000314

direct assay evidence used in manual assertion

P

  • causally_upstream_of:(GO:0005229)
  • occurs_in:(CL:1001451)

Seeded From UniProt

complete

involved_in

GO:0060438

trachea development

PMID:18585372[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006821

chloride transport

PMID:18724360[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:22075693[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:18585372[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005229

intracellular calcium activated chloride channel activity

PMID:22075693[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005229

intracellular calcium activated chloride channel activity

PMID:18724360[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902476

chloride transmembrane transport

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q5XXA6

P

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:23576756[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q8CFW1

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:23576756[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q8BHY3

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042391

regulation of membrane potential

PMID:23133519[7]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1918361

P

occurs_in:(EMAPA:32834)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042391

regulation of membrane potential

PMID:23133519[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(EMAPA:32834)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035774

positive regulation of insulin secretion involved in cellular response to glucose stimulus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q5XXA6

P

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

PMID:21516098[8]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:35613)
  • part_of:(CL:1001573)

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q5XXA6

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0015705

iodide transport

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q5XXA6

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0015705

iodide transport

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1310786

P

Seeded From UniProt

complete

enables

GO:0015111

iodide transmembrane transporter activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q5XXA6

F

Seeded From UniProt

complete

enables

GO:0015111

iodide transmembrane transporter activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1310786

F

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:23576756[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006821

chloride transport

PMID:23532839[9]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(CL:0002404)|occurs_in:(CL:0000578)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006821

chloride transport

PMID:20056604[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006821

chloride transport

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q5XXA6

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006821

chloride transport

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1310786

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006812

cation transport

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q5XXA6

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:20056604[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q5XXA6

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1310786

C

Seeded From UniProt

complete

enables

GO:0005254

chloride channel activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q5XXA6

F

Seeded From UniProt

complete

enables

GO:0005229

intracellular calcium activated chloride channel activity

PMID:23576756[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005229

intracellular calcium activated chloride channel activity

PMID:23532839[9]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_in:(CL:0002404)|occurs_in:(CL:0000578)

Seeded From UniProt

complete

enables

GO:0005229

intracellular calcium activated chloride channel activity

PMID:20056604[10]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005229

intracellular calcium activated chloride channel activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q5XXA6

F

Seeded From UniProt

complete

enables

GO:0005229

intracellular calcium activated chloride channel activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1310786

F

Seeded From UniProt

complete

enables

GO:0005227

calcium activated cation channel activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q5XXA6

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR031287

C

Seeded From UniProt

complete

involved_in

GO:0034605

cellular response to heat

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR031287

P

Seeded From UniProt

complete

involved_in

GO:0035774

positive regulation of insulin secretion involved in cellular response to glucose stimulus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR031287

P

Seeded From UniProt

complete

enables

GO:0046983

protein dimerization activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR032394

F

Seeded From UniProt

complete

involved_in

GO:1902476

chloride transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR031287

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0034707

chloride channel complex

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0869

C

Seeded From UniProt

complete

enables

GO:0005254

chloride channel activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0869

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0006821

chloride transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0869

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0406

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Edlund, A et al. (2014) CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells. BMC Med 12 87 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Cho, H et al. (2012) The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. Nat. Neurosci. 15 1015-21 PubMed GONUTS page
  3. 3.0 3.1 Rock, JR et al. (2008) The transmembrane protein TMEM16A is required for normal development of the murine trachea. Dev. Biol. 321 141-9 PubMed GONUTS page
  4. 4.0 4.1 Yang, YD et al. (2008) TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature 455 1210-5 PubMed GONUTS page
  5. 5.0 5.1 Duran, C et al. (2012) ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins. Am. J. Physiol., Cell Physiol. 302 C482-93 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 Tien, J et al. (2013) Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC). Proc. Natl. Acad. Sci. U.S.A. 110 6352-7 PubMed GONUTS page
  7. 7.0 7.1 Zeng, F et al. (2012) GPR39 is coupled to TMEM16A in intestinal fibroblast-like cells. PLoS ONE 7 e47686 PubMed GONUTS page
  8. Billig, GM et al. (2011) Ca2+-activated Cl− currents are dispensable for olfaction. Nat. Neurosci. 14 763-9 PubMed GONUTS page
  9. 9.0 9.1 Suzuki, J et al. (2013) Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members. J. Biol. Chem. 288 13305-16 PubMed GONUTS page
  10. 10.0 10.1 10.2 Schreiber, R et al. (2010) Expression and function of epithelial anoctamins. J. Biol. Chem. 285 7838-45 PubMed GONUTS page