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MOUSE:AMPD3

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Ampd3
Protein Name(s) AMP deaminase 3

AMP deaminase H-type AMP deaminase isoform E Heart-type AMPD

External Links
UniProt O08739
EMBL D85596
D88994
AK133465
CH466531
CH466531
CH466531
BC040366
BC056380
CCDS CCDS21747.1
RefSeq NP_001263230.1
NP_033797.2
XP_006507285.1
UniGene Mm.3238
ProteinModelPortal O08739
SMR O08739
IntAct O08739
MINT MINT-4115626
STRING 10090.ENSMUSP00000123052
PhosphoSite O08739
MaxQB O08739
PaxDb O08739
PRIDE O08739
Ensembl ENSMUST00000005829
ENSMUST00000170374
GeneID 11717
KEGG mmu:11717
UCSC uc009jfl.1
CTD 272
MGI MGI:1096344
eggNOG COG1816
GeneTree ENSGT00390000008190
HOGENOM HOG000092200
HOVERGEN HBG050494
InParanoid O08739
KO K01490
OMA MMELNEP
OrthoDB EOG70ZZMQ
PhylomeDB O08739
TreeFam TF300439
Reactome REACT_244050
UniPathway UPA00591
NextBio 279393
PRO PR:O08739
Proteomes UP000000589
Bgee O08739
CleanEx MM_AMPD3
ExpressionAtlas O08739
Genevestigator O08739
GO GO:0003876
GO:0046872
GO:0046031
GO:0046033
GO:0046034
GO:0097009
GO:0006188
GO:0032264
InterPro IPR006650
IPR001365
IPR006329
IPR029771
PANTHER PTHR11359
PTHR11359:SF2
Pfam PF00962
PIRSF PIRSF001251
TIGRFAMs TIGR01429
PROSITE PS00485

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0046033

AMP metabolic process

PMID:23078545[1]

ECO:0000315

P

Table 3 shows increase in AMP levels in AMPD3 knockout mice.

complete
CACAO 8514

GO:0034101

erythrocyte homeostasis

PMID:23078545[1]

ECO:0000315

P

Figure 3 shows increased levels of hemolysis based on salt concentrations in AMPD3 knockouts compared to wild-type mice when fasting.

complete
CACAO 8515

GO:0003876

AMP deaminase activity

PMID:23911318[2]

ECO:0000315

F

Figure 5C shows significantly decreased AMP Deaminase Activity in AMPD3 knockouts.

complete
CACAO 8529

GO:0046034

ATP metabolic process

PMID:23911318[2]

ECO:0000316

UniProtKB:Q9DBT5


P

Figure 5F, in mouse AMPD2/3 double knockouts, there was a 26% increase in ATP levels.

complete
CACAO 8530

GO:0046039

GTP metabolic process

PMID:23911318[2]

ECO:0000316

UniProtKB:Q9DBT5


P

In Figure 5f, mice AMPD2/3 double knockouts displayed a 33% decrease in GTP levels.

complete
CACAO 8531

GO:0046031

ADP metabolic process

PMID:23078545[1]

ECO:0000315

P

Table 3 shows increase in ADP levels in AMPD3 knockout mice.

complete
CACAO 8532

GO:0046039

GTP metabolic process

PMID:23078545[1]

ECO:0000315

P

Table 3 shows decrease in GTP levels in AMPD3 knockout mice.

complete
CACAO 8533

GO:0046034

ATP metabolic process

PMID:23078545[1]

ECO:0000315

P

Table 3 shows increase in ATP levels in AMPD3 knockout mice.

complete
CACAO 8534

involved_in

GO:0046031

ADP metabolic process

PMID:23078545[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046039

GTP metabolic process

PMID:23911318[2]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q9DBT5

P

Seeded From UniProt

complete

involved_in

GO:0046034

ATP metabolic process

PMID:23911318[2]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q9DBT5

P

Seeded From UniProt

complete

enables

GO:0003876

AMP deaminase activity

PMID:23911318[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0034101

erythrocyte homeostasis

PMID:23078545[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046033

AMP metabolic process

PMID:23078545[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046034

ATP metabolic process

PMID:23078545[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046039

GTP metabolic process

PMID:23078545[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046033

AMP metabolic process

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1096344
MGI:MGI:88016
PANTHER:PTN000144579

P

Seeded From UniProt

complete

involved_in

GO:0006188

IMP biosynthetic process

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1096344
MGI:MGI:88016
PANTHER:PTN000144579
UniProtKB:Q01433
dictyBase:DDB_G0292266

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000144579
TAIR:locus:2042902
UniProtKB:Q01433

C

Seeded From UniProt

complete

enables

GO:0003876

AMP deaminase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1096344
MGI:MGI:88016
PANTHER:PTN000144579
PomBase:SPBC106.04
RGD:2111
SGD:S000004498
TAIR:locus:2042902
UniProtKB:P23109
UniProtKB:Q01432
UniProtKB:Q01433
dictyBase:DDB_G0292266

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0097009

energy homeostasis

PMID:23911318[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:5529271

P

occurs_in:(EMAPA:16894)|occurs_in:(EMAPA:16846)|occurs_in:(EMAPA:16105)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046034

ATP metabolic process

PMID:23439682[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:4364610

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046033

AMP metabolic process

PMID:23439682[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:4364610

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046031

ADP metabolic process

PMID:23439682[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:4364610

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006188

IMP biosynthetic process

PMID:23911318[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:5529271

P

occurs_in:(EMAPA:16894)|occurs_in:(EMAPA:16846)|occurs_in:(EMAPA:16105)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006188

IMP biosynthetic process

PMID:23542464[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:5529271

P

occurs_in:(EMAPA:16728)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006188

IMP biosynthetic process

PMID:23078545[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:5529271

P

occurs_in:(CL:0000232)|occurs_in:(EMAPA:16846)|occurs_in:(EMAPA:17373)|occurs_in:(EMAPA:16105)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006188

IMP biosynthetic process

PMID:9133604[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003876

AMP deaminase activity

PMID:24940686[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

occurs_in:(EMAPA:16105)|occurs_in:(EMAPA:16332)|occurs_in:(EMAPA:17373)

Seeded From UniProt

complete

enables

GO:0003876

AMP deaminase activity

PMID:23911318[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:5529271

F

occurs_in:(EMAPA:16894)|occurs_in:(EMAPA:16846)|occurs_in:(EMAPA:16105)

Seeded From UniProt

complete

enables

GO:0003876

AMP deaminase activity

PMID:23542464[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:5529271

F

occurs_in:(EMAPA:16728)

Seeded From UniProt

complete

enables

GO:0003876

AMP deaminase activity

PMID:23078545[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:5529271

F

occurs_in:(CL:0000232)|occurs_in:(EMAPA:16846)|occurs_in:(EMAPA:17373)|occurs_in:(EMAPA:16105)

Seeded From UniProt

complete

enables

GO:0003876

AMP deaminase activity

PMID:9133604[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003876

AMP deaminase activity

PMID:24066180[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003876

AMP deaminase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2111

F

Seeded From UniProt

complete

enables

GO:0003876

AMP deaminase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006329
InterPro:IPR029771

F

Seeded From UniProt

complete

involved_in

GO:0009168

purine ribonucleoside monophosphate biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006650

P

Seeded From UniProt

complete

enables

GO:0019239

deaminase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001365
InterPro:IPR006650

F

Seeded From UniProt

complete

involved_in

GO:0032264

IMP salvage

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006329
InterPro:IPR029771

P

Seeded From UniProt

complete

enables

GO:0003876

AMP deaminase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.5.4.6

F

Seeded From UniProt

complete

involved_in

GO:0009117

nucleotide metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0546

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0032264

IMP salvage

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00591

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 Cheng, J et al. (2012) AMPD3-deficient mice exhibit increased erythrocyte ATP levels but anemia not improved due to PK deficiency. Genes Cells 17 913-22 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Akizu, N et al. (2013) AMPD2 regulates GTP synthesis and is mutated in a potentially treatable neurodegenerative brainstem disorder. Cell 154 505-17 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Yi, K et al. (2013) Sequential actin-based pushing forces drive meiosis I chromosome migration and symmetry breaking in oocytes. J. Cell Biol. 200 567-76 PubMed GONUTS page
  5. ↑ 5.0 5.1 Li, P et al. (2013) AMP deaminase 3 plays a critical role in remote reperfusion lung injury. Biochem. Biophys. Res. Commun. 434 131-6 PubMed GONUTS page
  6. ↑ 6.0 6.1 Wang, X et al. (1997) Cloning and expression of cDNA encoding heart-type isoform of AMP deaminase. Gene 188 285-90 PubMed GONUTS page
  7. ↑ Rybakowska, I et al. (2014) Effect of AMP-deaminase 3 knock-out in mice on enzyme activity in heart and other organs. Nucleosides Nucleotides Nucleic Acids 33 319-22 PubMed GONUTS page
  8. ↑ Daniels, IS et al. (2013) AMP deaminase 3 deficiency enhanced 5'-AMP induction of hypometabolism. PLoS ONE 8 e75418 PubMed GONUTS page
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