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MOUSE:AMPD3
Contents
Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
Gene Name(s) | Ampd3 | |
Protein Name(s) | AMP deaminase 3
AMP deaminase H-type AMP deaminase isoform E Heart-type AMPD | |
External Links | ||
UniProt | O08739 | |
EMBL | D85596 D88994 AK133465 CH466531 CH466531 CH466531 BC040366 BC056380 | |
CCDS | CCDS21747.1 | |
RefSeq | NP_001263230.1 NP_033797.2 XP_006507285.1 | |
UniGene | Mm.3238 | |
ProteinModelPortal | O08739 | |
SMR | O08739 | |
IntAct | O08739 | |
MINT | MINT-4115626 | |
STRING | 10090.ENSMUSP00000123052 | |
PhosphoSite | O08739 | |
MaxQB | O08739 | |
PaxDb | O08739 | |
PRIDE | O08739 | |
Ensembl | ENSMUST00000005829 ENSMUST00000170374 | |
GeneID | 11717 | |
KEGG | mmu:11717 | |
UCSC | uc009jfl.1 | |
CTD | 272 | |
MGI | MGI:1096344 | |
eggNOG | COG1816 | |
GeneTree | ENSGT00390000008190 | |
HOGENOM | HOG000092200 | |
HOVERGEN | HBG050494 | |
InParanoid | O08739 | |
KO | K01490 | |
OMA | MMELNEP | |
OrthoDB | EOG70ZZMQ | |
PhylomeDB | O08739 | |
TreeFam | TF300439 | |
Reactome | REACT_244050 | |
UniPathway | UPA00591 | |
NextBio | 279393 | |
PRO | PR:O08739 | |
Proteomes | UP000000589 | |
Bgee | O08739 | |
CleanEx | MM_AMPD3 | |
ExpressionAtlas | O08739 | |
Genevestigator | O08739 | |
GO | GO:0003876 GO:0046872 GO:0046031 GO:0046033 GO:0046034 GO:0097009 GO:0006188 GO:0032264 | |
InterPro | IPR006650 IPR001365 IPR006329 IPR029771 | |
PANTHER | PTHR11359 PTHR11359:SF2 | |
Pfam | PF00962 | |
PIRSF | PIRSF001251 | |
TIGRFAMs | TIGR01429 | |
PROSITE | PS00485 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0046033 |
AMP metabolic process |
ECO:0000315 |
P |
Table 3 shows increase in AMP levels in AMPD3 knockout mice. |
complete | |||||
GO:0034101 |
erythrocyte homeostasis |
ECO:0000315 |
P |
Figure 3 shows increased levels of hemolysis based on salt concentrations in AMPD3 knockouts compared to wild-type mice when fasting. |
complete | |||||
GO:0003876 |
AMP deaminase activity |
ECO:0000315 |
F |
Figure 5C shows significantly decreased AMP Deaminase Activity in AMPD3 knockouts. |
complete | |||||
GO:0046034 |
ATP metabolic process |
ECO:0000316 |
|
P |
Figure 5F, in mouse AMPD2/3 double knockouts, there was a 26% increase in ATP levels. |
complete | ||||
GO:0046039 |
GTP metabolic process |
ECO:0000316 |
|
P |
In Figure 5f, mice AMPD2/3 double knockouts displayed a 33% decrease in GTP levels. |
complete | ||||
GO:0046031 |
ADP metabolic process |
ECO:0000315 |
P |
Table 3 shows increase in ADP levels in AMPD3 knockout mice. |
complete | |||||
GO:0046039 |
GTP metabolic process |
ECO:0000315 |
P |
Table 3 shows decrease in GTP levels in AMPD3 knockout mice. |
complete | |||||
GO:0046034 |
ATP metabolic process |
ECO:0000315 |
P |
Table 3 shows increase in ATP levels in AMPD3 knockout mice. |
complete | |||||
involved_in |
GO:0046031 |
ADP metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0046039 |
GTP metabolic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0046034 |
ATP metabolic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0003876 |
AMP deaminase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034101 |
erythrocyte homeostasis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0046033 |
AMP metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0046034 |
ATP metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0046039 |
GTP metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0046033 |
AMP metabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1096344 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006188 |
IMP biosynthetic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1096344 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000144579 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003876 |
AMP deaminase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1096344 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0097009 |
energy homeostasis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:5529271 |
P |
occurs_in:(EMAPA:16894)|occurs_in:(EMAPA:16846)|occurs_in:(EMAPA:16105) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0046034 |
ATP metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4364610 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0046033 |
AMP metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4364610 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0046031 |
ADP metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:4364610 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0006188 |
IMP biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:5529271 |
P |
occurs_in:(EMAPA:16894)|occurs_in:(EMAPA:16846)|occurs_in:(EMAPA:16105) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0006188 |
IMP biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:5529271 |
P |
occurs_in:(EMAPA:16728) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0006188 |
IMP biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:5529271 |
P |
occurs_in:(CL:0000232)|occurs_in:(EMAPA:16846)|occurs_in:(EMAPA:17373)|occurs_in:(EMAPA:16105) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0006188 |
IMP biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0003876 |
AMP deaminase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
occurs_in:(EMAPA:16105)|occurs_in:(EMAPA:16332)|occurs_in:(EMAPA:17373) |
Seeded From UniProt |
complete | ||
enables |
GO:0003876 |
AMP deaminase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:5529271 |
F |
occurs_in:(EMAPA:16894)|occurs_in:(EMAPA:16846)|occurs_in:(EMAPA:16105) |
Seeded From UniProt |
complete | |
enables |
GO:0003876 |
AMP deaminase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:5529271 |
F |
occurs_in:(EMAPA:16728) |
Seeded From UniProt |
complete | |
enables |
GO:0003876 |
AMP deaminase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:5529271 |
F |
occurs_in:(CL:0000232)|occurs_in:(EMAPA:16846)|occurs_in:(EMAPA:17373)|occurs_in:(EMAPA:16105) |
Seeded From UniProt |
complete | |
enables |
GO:0003876 |
AMP deaminase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003876 |
AMP deaminase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003876 |
AMP deaminase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2111 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003876 |
AMP deaminase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009168 |
purine ribonucleoside monophosphate biosynthetic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0019239 |
deaminase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032264 |
IMP salvage |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0003876 |
AMP deaminase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009117 |
nucleotide metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032264 |
IMP salvage |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00591 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 Cheng, J et al. (2012) AMPD3-deficient mice exhibit increased erythrocyte ATP levels but anemia not improved due to PK deficiency. Genes Cells 17 913-22 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Akizu, N et al. (2013) AMPD2 regulates GTP synthesis and is mutated in a potentially treatable neurodegenerative brainstem disorder. Cell 154 505-17 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Yi, K et al. (2013) Sequential actin-based pushing forces drive meiosis I chromosome migration and symmetry breaking in oocytes. J. Cell Biol. 200 567-76 PubMed GONUTS page
- ↑ 5.0 5.1 Li, P et al. (2013) AMP deaminase 3 plays a critical role in remote reperfusion lung injury. Biochem. Biophys. Res. Commun. 434 131-6 PubMed GONUTS page
- ↑ 6.0 6.1 Wang, X et al. (1997) Cloning and expression of cDNA encoding heart-type isoform of AMP deaminase. Gene 188 285-90 PubMed GONUTS page
- ↑ Rybakowska, I et al. (2014) Effect of AMP-deaminase 3 knock-out in mice on enzyme activity in heart and other organs. Nucleosides Nucleotides Nucleic Acids 33 319-22 PubMed GONUTS page
- ↑ Daniels, IS et al. (2013) AMP deaminase 3 deficiency enhanced 5'-AMP induction of hypometabolism. PLoS ONE 8 e75418 PubMed GONUTS page