MOUSE:ACVL1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Acvrl1 (synonyms: Acvrlk1, Alk-1)
Protein Name(s)	Serine/threonine-protein kinase receptor R3 SKR3 Activin receptor-like kinase 1 ALK-1 TGF-B superfamily receptor type I TSR-I
External Links
UniProt	Q61288
EMBL	L48015 Z31664 AK160915 AK170870 CH466550 CH466550 BC015083
CCDS	CCDS37215.1
PIR	I48241 JC4337
RefSeq	NP_001264186.1 NP_001264187.1 NP_001264188.1 NP_033742.2
UniGene	Mm.279542
ProteinModelPortal	Q61288
SMR	Q61288
BioGrid	197957
DIP	DIP-47635N
IntAct	Q61288
MINT	MINT-4086807
BindingDB	Q61288
PhosphoSite	Q61288
PaxDb	Q61288
PRIDE	Q61288
Ensembl	ENSMUST00000000542 ENSMUST00000117984 ENSMUST00000119063 ENSMUST00000120028 ENSMUST00000120754 ENSMUST00000121718
GeneID	11482
KEGG	mmu:11482
UCSC	uc007xsm.1
CTD	94
MGI	MGI:1338946
eggNOG	COG0515
GeneTree	ENSGT00760000118876
HOGENOM	HOG000230587
HOVERGEN	HBG054502
InParanoid	Q61288
KO	K13594
OMA	WHVRRRQ
OrthoDB	EOG7Q8CN3
TreeFam	TF314724
BRENDA	2.7.10.2
NextBio	278836
PRO	PR:Q61288
Proteomes	UP000000589
Bgee	Q61288
CleanEx	MM_ACVRL1
ExpressionAtlas	Q61288
Genevestigator	Q61288
GO	GO:0009986 GO:0030425 GO:0005887 GO:0043025 GO:0016361 GO:0005524 GO:0046872 GO:0004702 GO:0005025 GO:0001525 GO:0060840 GO:0048514 GO:0001974 GO:0030509 GO:0071773 GO:0071560 GO:0042118 GO:0061154 GO:0001701 GO:0001946 GO:0060836 GO:0043537 GO:0030308 GO:2000279 GO:0045602 GO:0001937 GO:0051895 GO:0045766 GO:0030513 GO:0045603 GO:0001938 GO:0010862 GO:0045944 GO:0045893 GO:0051291 GO:0008217 GO:0061298 GO:0007179 GO:0060841 GO:0035313
InterPro	IPR000472 IPR011009 IPR000719 IPR017441 IPR008271 IPR003605 IPR000333
PANTHER	PTHR23255
Pfam	PF01064 PF00069 PF08515
SMART	SM00467
SUPFAM	SSF56112
PROSITE	PS51256 PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0010629	negative regulation of gene expression	PMID:12941632^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q64314) occurs_in:(UBERON:0006296)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:12941632^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P52800) occurs_in:(UBERON:0004537)	Seeded From UniProt	complete
NOT\|involved_in	GO:0090500	endocardial cushion to mesenchymal transition	PMID:12941632^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035912	dorsal aorta morphogenesis	PMID:12941632^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003203	endocardial cushion morphogenesis	PMID:12941632^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37023	C		Seeded From UniProt	complete
enables	GO:0098821	BMP receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37023	F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:20406889^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045603	positive regulation of endothelial cell differentiation	PMID:20406889^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045602	negative regulation of endothelial cell differentiation	PMID:20406889^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030513	positive regulation of BMP signaling pathway	PMID:20406889^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:20406889^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001937	negative regulation of endothelial cell proliferation	PMID:20406889^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	PMID:19494318^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000138)	Seeded From UniProt	complete
involved_in	GO:0061298	retina vasculature development in camera-type eye	PMID:19903896^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060841	venous blood vessel development	PMID:19903896^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0061298)	Seeded From UniProt	complete
involved_in	GO:0060840	artery development	PMID:19903896^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0061298)	Seeded From UniProt	complete
involved_in	GO:0060836	lymphatic endothelial cell differentiation	PMID:19903896^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001974	blood vessel remodeling	PMID:19903896^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0061298)	Seeded From UniProt	complete
involved_in	GO:0001946	lymphangiogenesis	PMID:19903896^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0098821	BMP receptor activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002356032 UniProtKB:P37023	F		Seeded From UniProt	complete
enables	GO:0048185	activin binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN002356032 UniProtKB:P37023 UniProtKB:Q04771	F		Seeded From UniProt	complete
part_of	GO:0048179	activin receptor complex	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002356032 RGD:620200 UniProtKB:Q04771	C		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 RGD:621789 UniProtKB:O00238 UniProtKB:P36894 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 UniProtKB:Q04771	F		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000583675 UniProtKB:P27037 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:P37173 UniProtKB:Q13705	C		Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102806 MGI:MGI:87911 MGI:MGI:87912 PANTHER:PTN000583675 RGD:71082 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:Q13705 UniProtKB:Q8NER5	F		Seeded From UniProt	complete
contributes_to	GO:0016361	activin receptor activity, type I	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN002356032 RGD:620200 UniProtKB:P37023 UniProtKB:Q04771	F		Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338938 MGI:MGI:87912 PANTHER:PTN000583675	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003716 MGI:MGI:1338946 MGI:MGI:87911 MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 RGD:3852 RGD:620200 RGD:69651 RGD:70964 UniProtKB:A0A0B4KG59 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 UniProtKB:Q04771 UniProtKB:Q06900 UniProtKB:Q90ZK6	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN000583675 RGD:69651 RGD:70964 UniProtKB:P36896 UniProtKB:P37023 UniProtKB:Q04771 UniProtKB:Q13873	C		Seeded From UniProt	complete
enables	GO:0005025	transforming growth factor beta receptor activity, type I	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN002356032 UniProtKB:A0A0B4K7J3 UniProtKB:P37023 UniProtKB:Q90ZK6	F		Seeded From UniProt	complete
enables	GO:0005024	transforming growth factor beta-activated receptor activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 UniProtKB:A0A0B4KG59 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 ZFIN:ZDB-GENE-070618-1	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000279	negative regulation of DNA biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	P		Seeded From UniProt	complete
enables	GO:0098821	BMP receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071773	cellular response to BMP stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061154	endothelial tube morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060836	lymphatic endothelial cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051895	negative regulation of focal adhesion assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	P		Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048514	blood vessel morphogenesis	PMID:17911384^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2680088	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048514	blood vessel morphogenesis	PMID:17530030^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2680088	P	has_participant:(EMAPA:16370)	Seeded From UniProt	complete
enables	GO:0048185	activin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	F		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045766	positive regulation of angiogenesis	PMID:23868260^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1924155	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043537	negative regulation of blood vessel endothelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2029	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035313	wound healing, spreading of epidermal cells	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030513	positive regulation of BMP signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	PMID:22783020^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3604490	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2029	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030336	negative regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030308	negative regulation of cell growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	F		Seeded From UniProt	complete
enables	GO:0016361	activin receptor activity, type I	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010596	negative regulation of endothelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2029	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008217	regulation of blood pressure	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008015	blood circulation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:14580334^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007165	signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007162	negative regulation of cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	F		Seeded From UniProt	complete
enables	GO:0005025	transforming growth factor beta receptor activity, type I	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	F		Seeded From UniProt	complete
enables	GO:0005024	transforming growth factor beta-activated receptor activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:17911384^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2680088	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	PMID:11062473^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2155981	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	PMID:10716993^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2155980	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37023	P		Seeded From UniProt	complete
involved_in	GO:0032924	activin receptor signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016361	P		Seeded From UniProt	complete
involved_in	GO:0032924	activin receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016361	P		Seeded From UniProt	complete
involved_in	GO:0032924	activin receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016361	P		Seeded From UniProt	complete
involved_in	GO:2000279	negative regulation of DNA biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	P		Seeded From UniProt	complete
enables	GO:0098821	BMP receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	F		Seeded From UniProt	complete
involved_in	GO:0071773	cellular response to BMP stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	P		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	P		Seeded From UniProt	complete
involved_in	GO:0061154	endothelial tube morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	P		Seeded From UniProt	complete
involved_in	GO:0060836	lymphatic endothelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	P		Seeded From UniProt	complete
involved_in	GO:0051895	negative regulation of focal adhesion assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	P		Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	F		Seeded From UniProt	complete
enables	GO:0048185	activin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	F		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	P		Seeded From UniProt	complete
involved_in	GO:0043537	negative regulation of blood vessel endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	P		Seeded From UniProt	complete
involved_in	GO:0035313	wound healing, spreading of epidermal cells	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	P		Seeded From UniProt	complete
involved_in	GO:0030513	positive regulation of BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	P		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	F		Seeded From UniProt	complete
enables	GO:0016361	activin receptor activity, type I	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	F		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	P		Seeded From UniProt	complete
involved_in	GO:0010596	negative regulation of endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	C		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	P		Seeded From UniProt	complete
involved_in	GO:0008217	regulation of blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	P		Seeded From UniProt	complete
involved_in	GO:0008015	blood circulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	P		Seeded From UniProt	complete
involved_in	GO:0007162	negative regulation of cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	F		Seeded From UniProt	complete
enables	GO:0005025	transforming growth factor beta receptor activity, type I	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	F		Seeded From UniProt	complete
enables	GO:0005024	transforming growth factor beta-activated receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	F		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37023 ensembl:ENSP00000373574	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P80203 ensembl:ENSRNOP00000072526	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P80203 ensembl:ENSRNOP00000072526	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P80203 ensembl:ENSRNOP00000072526	C		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P80203 ensembl:ENSRNOP00000072526	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR003605	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000719 InterPro:IPR003605 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR003605 InterPro:IPR008271	P		Seeded From UniProt	complete
involved_in	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR003605	C		Seeded From UniProt	complete
involved_in	GO:0042118	endothelial cell activation	PMID:20406889^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Sorensen, LK et al. (2003) Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFbeta coreceptor. Dev. Biol. 261 235-50 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Suzuki, Y et al. (2010) BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo. J. Cell. Sci. 123 1684-92 PubMed GONUTS page
↑ Blaney Davidson, EN et al. (2009) Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice. J. Immunol. 182 7937-45 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Niessen, K et al. (2010) ALK1 signaling regulates early postnatal lymphatic vessel development. Blood 115 1654-61 PubMed GONUTS page
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.0 ^6.1 Park, SO et al. (2008) ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2. Blood 111 633-42 PubMed GONUTS page
↑ Hong, KH et al. (2007) Activin receptor-like kinase 1 is essential for placental vascular development in mice. Lab. Invest. 87 670-9 PubMed GONUTS page
↑ Wang, X et al. (2013) LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling. Nature 499 306-11 PubMed GONUTS page
↑ Somekawa, S et al. (2012) Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis. Proc. Natl. Acad. Sci. U.S.A. 109 12064-9 PubMed GONUTS page
↑ Goumans, MJ et al. (2003) Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling. Mol. Cell 12 817-28 PubMed GONUTS page
↑ Urness, LD et al. (2000) Arteriovenous malformations in mice lacking activin receptor-like kinase-1. Nat. Genet. 26 328-31 PubMed GONUTS page
↑ Oh, SP et al. (2000) Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. Proc. Natl. Acad. Sci. U.S.A. 97 2626-31 PubMed GONUTS page

[PMID:12941632-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Sorensen, LK et al. (2003) Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFbeta coreceptor. Dev. Biol. 261 235-50 PubMed GONUTS page

[PMID:20406889-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Suzuki, Y et al. (2010) BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo. J. Cell. Sci. 123 1684-92 PubMed GONUTS page

[PMID:19494318-3] Blaney Davidson, EN et al. (2009) Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice. J. Immunol. 182 7937-45 PubMed GONUTS page

[PMID:19903896-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Niessen, K et al. (2010) ALK1 signaling regulates early postnatal lymphatic vessel development. Blood 115 1654-61 PubMed GONUTS page

[PMID:21873635-5] 5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17911384-6] 6.0 ^6.1 Park, SO et al. (2008) ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2. Blood 111 633-42 PubMed GONUTS page

[PMID:17530030-7] Hong, KH et al. (2007) Activin receptor-like kinase 1 is essential for placental vascular development in mice. Lab. Invest. 87 670-9 PubMed GONUTS page

[PMID:23868260-8] Wang, X et al. (2013) LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling. Nature 499 306-11 PubMed GONUTS page

[PMID:22783020-9] Somekawa, S et al. (2012) Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis. Proc. Natl. Acad. Sci. U.S.A. 109 12064-9 PubMed GONUTS page

[PMID:14580334-10] Goumans, MJ et al. (2003) Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling. Mol. Cell 12 817-28 PubMed GONUTS page

[PMID:11062473-11] Urness, LD et al. (2000) Arteriovenous malformations in mice lacking activin receptor-like kinase-1. Nat. Genet. 26 328-31 PubMed GONUTS page

[PMID:10716993-12] Oh, SP et al. (2000) Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. Proc. Natl. Acad. Sci. U.S.A. 97 2626-31 PubMed GONUTS page

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MOUSE:ACVL1

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