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MOUSE:ACE2
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Ace2 | |
| Protein Name(s) | Angiotensin-converting enzyme 2
ACE-related carboxypeptidase Processed angiotensin-converting enzyme 2 | |
| External Links | ||
| UniProt | Q8R0I0 | |
| EMBL | AB053181 AB053182 BC026801 | |
| CCDS | CCDS30518.1 | |
| RefSeq | NP_001123985.1 NP_081562.2 | |
| UniGene | Mm.13451 | |
| ProteinModelPortal | Q8R0I0 | |
| SMR | Q8R0I0 | |
| IntAct | Q8R0I0 | |
| MINT | MINT-4118343 | |
| MEROPS | M02.006 | |
| PhosphoSite | Q8R0I0 | |
| MaxQB | Q8R0I0 | |
| PaxDb | Q8R0I0 | |
| PRIDE | Q8R0I0 | |
| Ensembl | ENSMUST00000073973 ENSMUST00000112271 | |
| GeneID | 70008 | |
| KEGG | mmu:70008 | |
| UCSC | uc009uvf.2 | |
| CTD | 59272 | |
| MGI | MGI:1917258 | |
| eggNOG | NOG71044 | |
| GeneTree | ENSGT00520000055576 | |
| HOGENOM | HOG000292210 | |
| HOVERGEN | HBG000265 | |
| InParanoid | Q8R0I0 | |
| KO | K09708 | |
| OMA | CNPNNPQ | |
| OrthoDB | EOG76HQ13 | |
| PhylomeDB | Q8R0I0 | |
| TreeFam | TF312861 | |
| Reactome | REACT_196539 | |
| NextBio | 330793 | |
| PRO | PR:Q8R0I0 | |
| Proteomes | UP000000589 | |
| Bgee | Q8R0I0 | |
| ExpressionAtlas | Q8R0I0 | |
| Genevestigator | Q8R0I0 | |
| GO | GO:0009986 GO:0005737 GO:0005615 GO:0070062 GO:0016021 GO:0005886 GO:0004180 GO:0004175 GO:0046872 GO:0008237 GO:0017046 GO:0008241 GO:0001618 GO:0003051 GO:0060135 GO:0032800 GO:0046813 | |
| InterPro | IPR001548 | |
| PANTHER | PTHR10514 | |
| Pfam | PF01401 | |
| PRINTS | PR00791 | |
| PROSITE | PS00678 PS00142 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0015827 |
tryptophan transport |
ECO:0000315 |
P |
To demonstrate that the severe colitis in Ace2 deficient mice is due to impaired tryptophan uptake, we provided tryptophan in form of a Gly-Trp dipeptide to bypass the loss of the single amino acid transporter B0AT1. Dietary dipeptidic tryptophan (a Trp+ diet) restored serum tryptophan levels (Supplementary Fig. 16a) and rescued the enhanced DSS-susceptibility of Ace2−/y mice (Fig. 2d–f; Supplementary Fig. 16b–d). Our results show that deficiency of Ace2 causes a critical impairment of local tryptophan homeostasis which alters the susceptibility to intestinal inflammation. |
complete | |||||
|
involved_in |
GO:0060452 |
positive regulation of cardiac muscle contraction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0015827 |
tryptophan transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031526 |
brush border membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001618 |
virus receptor activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008238 |
exopeptidase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001630211 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1917258 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0012037 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004180 |
carboxypeptidase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002575178 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0003081 |
regulation of systemic arterial blood pressure by renin-angiotensin |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002575179 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1903779 |
regulation of cardiac conduction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1903598 |
positive regulation of gap junction assembly |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0070373 |
negative regulation of ERK1 and ERK2 cascade |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:728890 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0051957 |
positive regulation of amino acid transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0048662 |
negative regulation of smooth muscle cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:728890 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0046813 |
receptor-mediated virion attachment to host cell |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032800 |
receptor biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:728890 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:728890 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004181 |
metallocarboxypeptidase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004180 |
carboxypeptidase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004180 |
carboxypeptidase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:728890 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004175 |
endopeptidase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0003081 |
regulation of systemic arterial blood pressure by renin-angiotensin |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0003051 |
angiotensin-mediated drinking behavior |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001618 |
virus receptor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046718 |
viral entry into host cell |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0001618 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046718 |
viral entry into host cell |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0001618 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046718 |
viral entry into host cell |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0001618 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1903779 |
regulation of cardiac conduction |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9BYF1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1903598 |
positive regulation of gap junction assembly |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9BYF1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051957 |
positive regulation of amino acid transport |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9BYF1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046813 |
receptor-mediated virion attachment to host cell |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9BYF1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032800 |
receptor biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9BYF1 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9BYF1 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9BYF1 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9BYF1 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9BYF1 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004180 |
carboxypeptidase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9BYF1 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004175 |
endopeptidase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9BYF1 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0003081 |
regulation of systemic arterial blood pressure by renin-angiotensin |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9BYF1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0003051 |
angiotensin-mediated drinking behavior |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9BYF1 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001618 |
virus receptor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9BYF1 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008237 |
metallopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008241 |
peptidyl-dipeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004180 |
carboxypeptidase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004180 |
carboxypeptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008237 |
metallopeptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Hashimoto, T et al. (2012) ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature 487 477-81 PubMed GONUTS page
- ↑ 2.0 2.1 Crackower, MA et al. (2002) Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature 417 822-8 PubMed GONUTS page
- ↑ 3.0 3.1 Xiao, L et al. (2013) Angiotensin II regulates ACE and ACE2 in neurons through p38 mitogen-activated protein kinase and extracellular signal-regulated kinase 1/2 signaling. Am. J. Physiol., Cell Physiol. 304 C1073-9 PubMed GONUTS page
- ↑ Camargo, SM et al. (2009) Tissue-specific amino acid transporter partners ACE2 and collectrin differentially interact with hartnup mutations. Gastroenterology 136 872-82 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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- GO:0008233 ! peptidase activity
- GO:0008241 ! peptidyl-dipeptidase activity
- GO:0005886 ! plasma membrane
- GO:0060452 ! positive regulation of cardiac muscle contraction
- GO:0051957 ! positive regulation of amino acid transport
- GO:1903598 ! positive regulation of gap junction assembly
- GO:0006508 ! proteolysis
r
