MOUSE:ABHD5

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Abhd5
Protein Name(s)	1-acylglycerol-3-phosphate O-acyltransferase ABHD5 Abhydrolase domain-containing protein 5 Lipid droplet-binding protein CGI-58 Protein CGI-58
External Links
UniProt	Q9DBL9
EMBL	AK004873 AK019488 AK050377 BC037063
CCDS	CCDS23646.1
RefSeq	NP_080455.1 XP_006512308.1
UniGene	Mm.280254
ProteinModelPortal	Q9DBL9
SMR	Q9DBL9
BioGrid	212211
MEROPS	S33.975
PhosphoSite	Q9DBL9
MaxQB	Q9DBL9
PaxDb	Q9DBL9
PRIDE	Q9DBL9
Ensembl	ENSMUST00000111497 ENSMUST00000156520
GeneID	67469
KEGG	mmu:67469
UCSC	uc009sew.1 uc009sey.1
CTD	51099
MGI	MGI:1914719
eggNOG	COG0596
GeneTree	ENSGT00390000016277
HOVERGEN	HBG054445
InParanoid	Q9DBL9
KO	K13699
OMA	SNGNKIW
OrthoDB	EOG751NG1
PhylomeDB	Q9DBL9
TreeFam	TF314196
Reactome	REACT_245618
ChiTaRS	Abhd5
NextBio	324670
PRO	PR:Q9DBL9
Proteomes	UP000000589
Bgee	Q9DBL9
CleanEx	MM_ABHD5
ExpressionAtlas	Q9DBL9
Genevestigator	Q9DBL9
GO	GO:0005829 GO:0005811 GO:0005634 GO:0003841 GO:0030154 GO:0006631 GO:0006629 GO:0010891 GO:0006654 GO:0051006 GO:0010898
Gene3D	3.40.50.1820
InterPro	IPR029058 IPR000073
PRINTS	PR00111
SUPFAM	SSF53474

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0050996	positive regulation of lipid catabolic process	PMID:22383684^[1]	ECO:0000315			P	Figure 4	complete CACAO 3960
involved_in	GO:0050996	positive regulation of lipid catabolic process	PMID:22383684^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010898	positive regulation of triglyceride catabolic process	PMID:16679289^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010891	negative regulation of sequestering of triglyceride	PMID:16679289^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006654	phosphatidic acid biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8WTS1	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:18606822^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	PMID:21148142^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	PMID:18606822^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
NOT\|enables	GO:0004806	triglyceride lipase activity	PMID:16679289^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0055088	lipid homeostasis	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000105999 UniProtKB:O22975	P	Seeded From UniProt	complete
enables	GO:0052689	carboxylic ester hydrolase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0033226 PANTHER:PTN000105999	F	Seeded From UniProt	complete
enables	GO:0042171	lysophosphatidic acid acyltransferase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000106030 UniProtKB:Q8WTS1	F	Seeded From UniProt	complete
involved_in	GO:0010898	positive regulation of triglyceride catabolic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1914719 PANTHER:PTN000106030 UniProtKB:Q8WTS1	P	Seeded From UniProt	complete
involved_in	GO:0006654	phosphatidic acid biosynthetic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000106030 UniProtKB:Q8WTS1	P	Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1914719 PANTHER:PTN000106030 RGD:1303237 UniProtKB:Q8WTS1	C	Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1914719 PANTHER:PTN000106002 RGD:1303237 UniProtKB:Q8WTS1 WB:WBGene00007711	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051006	positive regulation of lipoprotein lipase activity	PMID:17074755^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042171	lysophosphatidic acid acyltransferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8WTS1	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010898	positive regulation of triglyceride catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8WTS1	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010891	negative regulation of sequestering of triglyceride	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8WTS1	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006654	phosphatidic acid biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8WTS1	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006629	lipid metabolic process	PMID:15136565^[7]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6QA69	P	Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8WTS1	C	Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1303237	C	Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6QA69 ensembl:ENSRNOP00000000239	P	Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6QA69 ensembl:ENSRNOP00000000239	C	Seeded From UniProt	complete
enables	GO:0042171	lysophosphatidic acid acyltransferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8WTS1 ensembl:ENSP00000495778	F	Seeded From UniProt	complete
involved_in	GO:0010898	positive regulation of triglyceride catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8WTS1 ensembl:ENSP00000495778	P	Seeded From UniProt	complete
involved_in	GO:0010891	negative regulation of sequestering of triglyceride	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8WTS1 ensembl:ENSP00000495778	P	Seeded From UniProt	complete
involved_in	GO:0006654	phosphatidic acid biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8WTS1 ensembl:ENSP00000495778	P	Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8WTS1 ensembl:ENSP00000495778	C	Seeded From UniProt	complete
enables	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.3.1.51	F	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-163511	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	Reactome:R-MMU-163511	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
involved_in	GO:0008654	phospholipid biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0594	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0551 UniProtKB-SubCell:SL-0154	C	Seeded From UniProt	complete
enables	GO:0016746	transferase activity, transferring acyl groups	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0012	F	Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0276	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Badin, PM et al. (2012) Regulation of skeletal muscle lipolysis and oxidative metabolism by the co-lipase CGI-58. J. Lipid Res. 53 839-48 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Lass, A et al. (2006) Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome. Cell Metab. 3 309-19 PubMed GONUTS page
↑ ^3.0 ^3.1 Ghosh, AK et al. (2008) CGI-58, the causative gene for Chanarin-Dorfman syndrome, mediates acylation of lysophosphatidic acid. J. Biol. Chem. 283 24525-33 PubMed GONUTS page
↑ Granneman, JG et al. (2011) Interactions of perilipin-5 (Plin5) with adipose triglyceride lipase. J. Biol. Chem. 286 5126-35 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Schweiger, M et al. (2006) Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism. J. Biol. Chem. 281 40236-41 PubMed GONUTS page
↑ Yamaguchi, T et al. (2004) CGI-58 interacts with perilipin and is localized to lipid droplets. Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome. J. Biol. Chem. 279 30490-7 PubMed GONUTS page

[PMID:22383684-1] 1.0 ^1.1 Badin, PM et al. (2012) Regulation of skeletal muscle lipolysis and oxidative metabolism by the co-lipase CGI-58. J. Lipid Res. 53 839-48 PubMed GONUTS page

[PMID:16679289-2] 2.0 ^2.1 ^2.2 Lass, A et al. (2006) Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome. Cell Metab. 3 309-19 PubMed GONUTS page

[PMID:18606822-3] 3.0 ^3.1 Ghosh, AK et al. (2008) CGI-58, the causative gene for Chanarin-Dorfman syndrome, mediates acylation of lysophosphatidic acid. J. Biol. Chem. 283 24525-33 PubMed GONUTS page

[PMID:21148142-4] Granneman, JG et al. (2011) Interactions of perilipin-5 (Plin5) with adipose triglyceride lipase. J. Biol. Chem. 286 5126-35 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17074755-6] Schweiger, M et al. (2006) Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism. J. Biol. Chem. 281 40236-41 PubMed GONUTS page

[PMID:15136565-7] Yamaguchi, T et al. (2004) CGI-58 interacts with perilipin and is localized to lipid droplets. Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome. J. Biol. Chem. 279 30490-7 PubMed GONUTS page

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MOUSE:ABHD5

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