MOUSE:A1AT1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Serpina1a (synonyms: Dom1, Spi1-1)
Protein Name(s)	Alpha-1-antitrypsin 1-1 AAT Alpha-1 protease inhibitor 1 Alpha-1-antiproteinase Serine protease inhibitor 1-1 Serine protease inhibitor A1a Serpin A1a
External Links
UniProt	P07758
EMBL	M75721 AF481949 AK146619 BC011040 BC037007 BC049970 BC057982 BC057984 BC057989 AH002568
CCDS	CCDS26140.1
PIR	I49470
RefSeq	NP_033269.1
UniGene	Mm.439692
ProteinModelPortal	P07758
SMR	P07758
BioGrid	203427
IntAct	P07758
MINT	MINT-4086354
MEROPS	I04.001
PhosphoSite	P07758
PaxDb	P07758
PRIDE	P07758
Ensembl	ENSMUST00000085056
GeneID	20700
KEGG	mmu:20700
UCSC	uc007owh.1
CTD	20700
MGI	MGI:891971
eggNOG	COG4826
GeneTree	ENSGT00760000118839
HOGENOM	HOG000238521
HOVERGEN	HBG005957
InParanoid	P07758
KO	K03984
OMA	THEDEIH
OrthoDB	EOG7QC7W9
PhylomeDB	P07758
TreeFam	TF343201
NextBio	299247
PRO	PR:P07758
Proteomes	UP000000589
Bgee	P07758
ExpressionAtlas	P07758
Genevestigator	P07758
GO	GO:0005576 GO:0005615 GO:0004867 GO:0006953 GO:0010951 GO:0006487 GO:0030162 GO:0034097 GO:0043434
InterPro	IPR023795 IPR023796 IPR000215
PANTHER	PTHR11461
Pfam	PF00079
SMART	SM00093
SUPFAM	SSF56574
PROSITE	PS00284

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28071719^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0000006)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:22159717^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0002048)	Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0028988 FB:FBgn0265137 PANTHER:PTN000156123 RGD:3249 UniProtKB:P05121 UniProtKB:P29508 UniProtKB:P35237 UniProtKB:P50452 UniProtKB:P50453 UniProtKB:Q9UIV8	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002930 FB:FBgn0015586 FB:FBgn0028986 FB:FBgn0031973 FB:FBgn0262057 FB:FBgn0265137 MGI:MGI:108080 MGI:MGI:1915304 MGI:MGI:87963 MGI:MGI:88278 MGI:MGI:894696 PANTHER:PTN000156123 RGD:1306692 RGD:1307404 RGD:2069 RGD:3249 RGD:3326 RGD:3747 RGD:3748 RGD:619833 RGD:631369 RGD:735225 UniProtKB:P01008 UniProtKB:P01009 UniProtKB:P01011 UniProtKB:P01019 UniProtKB:P05121 UniProtKB:P05154 UniProtKB:P08697 UniProtKB:P50453 UniProtKB:Q90935 UniProtKB:Q99574 UniProtKB:Q9TTE1	C		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002930 FB:FBgn0028983 FB:FBgn0028988 FB:FBgn0028990 FB:FBgn0265137 MGI:MGI:101780 MGI:MGI:106603 MGI:MGI:1277952 MGI:MGI:2445361 MGI:MGI:2683293 MGI:MGI:891970 MGI:MGI:894696 MGI:MGI:97608 PANTHER:PTN000156123 RGD:1306692 RGD:1307404 RGD:3249 RGD:3326 RGD:3748 RGD:619817 RGD:619896 RGD:619897 UniProtKB:P01009 UniProtKB:P01012 UniProtKB:P05121 UniProtKB:P05154 UniProtKB:P05155 UniProtKB:P07093 UniProtKB:P08697 UniProtKB:P35237 UniProtKB:P48594 UniProtKB:P50452 UniProtKB:P50453 UniProtKB:Q3ZEJ6 UniProtKB:Q86WD7 UniProtKB:Q90935 UniProtKB:Q96P63 UniProtKB:Q99574 UniProtKB:Q9TTE1 UniProtKB:Q9UIV8 WB:WBGene00005643	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043434	response to peptide hormone	PMID:15795238^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_participant:(EMAPA:32760)	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01009	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01009	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034097	response to cytokine	PMID:15795238^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:32760)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006487	protein N-linked glycosylation	PMID:11961105^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01009	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01009	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01009	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3326	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:11961105^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3326	F		Seeded From UniProt	complete
enables	GO:0004866	endopeptidase inhibitor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3326	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01009	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000215	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
enables	GO:0030414	peptidase inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0646	F		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0722	F		Seeded From UniProt	complete
involved_in	GO:0006953	acute-phase response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0011	P		Seeded From UniProt	complete
involved_in	GO:0010466	negative regulation of peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0646	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Naba, A et al. (2017) Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep 7 40495 PubMed GONUTS page
↑ Naba, A et al. (2012) The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell Proteomics 11 M111.014647 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 Winkler, IG et al. (2005) Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization. J. Exp. Med. 201 1077-88 PubMed GONUTS page
↑ ^5.0 ^5.1 Barbour, KW et al. (2002) Functional diversification during evolution of the murine alpha(1)-proteinase inhibitor family: role of the hypervariable reactive center loop. Mol. Biol. Evol. 19 718-27 PubMed GONUTS page

[PMID:28071719-1] Naba, A et al. (2017) Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep 7 40495 PubMed GONUTS page

[PMID:22159717-2] Naba, A et al. (2012) The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell Proteomics 11 M111.014647 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15795238-4] 4.0 ^4.1 Winkler, IG et al. (2005) Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization. J. Exp. Med. 201 1077-88 PubMed GONUTS page

[PMID:11961105-5] 5.0 ^5.1 Barbour, KW et al. (2002) Functional diversification during evolution of the murine alpha(1)-proteinase inhibitor family: role of the hypervariable reactive center loop. Mol. Biol. Evol. 19 718-27 PubMed GONUTS page

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MOUSE:A1AT1

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