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MOUSE:5HT1B
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Htr1b (synonyms: 5ht1b) | |
| Protein Name(s) | 5-hydroxytryptamine receptor 1B
5-HT-1B 5-HT1B Serotonin receptor 1B | |
| External Links | ||
| UniProt | P28334 | |
| EMBL | Z11597 M85151 | |
| CCDS | CCDS23370.1 | |
| PIR | A42688 | |
| RefSeq | NP_034612.1 | |
| UniGene | Mm.445308 | |
| ProteinModelPortal | P28334 | |
| STRING | 10090.ENSMUSP00000050898 | |
| BindingDB | P28334 | |
| ChEMBL | CHEMBL3708691 | |
| GuidetoPHARMACOLOGY | 2 | |
| iPTMnet | P28334 | |
| PhosphoSitePlus | P28334 | |
| PaxDb | P28334 | |
| PRIDE | P28334 | |
| Ensembl | ENSMUST00000051005 ENSMUST00000183482 | |
| GeneID | 15551 | |
| KEGG | mmu:15551 | |
| UCSC | uc009qvl.1 | |
| CTD | 3351 | |
| MGI | MGI:96274 | |
| eggNOG | KOG3656 ENOG410XRW9 | |
| GeneTree | ENSGT00760000118795 | |
| HOGENOM | HOG000239242 | |
| HOVERGEN | HBG106962 | |
| InParanoid | P28334 | |
| KO | K04153 | |
| OMA | VNTDHVL | |
| OrthoDB | EOG091G06VI | |
| PhylomeDB | P28334 | |
| TreeFam | TF316350 | |
| Reactome | R-MMU-390666 R-MMU-418594 | |
| PRO | PR:P28334 | |
| Proteomes | UP000000589 | |
| Bgee | ENSMUSG00000049511 | |
| CleanEx | MM_HTR1B | |
| ExpressionAtlas | P28334 | |
| Genevisible | P28334 | |
| GO | GO:0044305 GO:0005737 GO:0005887 GO:0005886 GO:0008144 GO:0004993 GO:0030594 GO:0051378 GO:0007193 GO:0007198 GO:0046849 GO:0071312 GO:0035690 GO:0071502 GO:0007268 GO:0042756 GO:0007631 GO:0002031 GO:0014063 GO:0032229 GO:0051967 GO:1904707 GO:0099171 GO:0007205 GO:0050795 GO:0014059 GO:2000300 GO:0042220 GO:0042493 GO:0045471 GO:0051385 GO:0042310 | |
| InterPro | IPR002147 IPR002231 IPR000276 IPR017452 | |
| PANTHER | PTHR24247:SF16 | |
| Pfam | PF00001 | |
| PRINTS | PR00513 PR01101 PR00237 | |
| SMART | SM01381 | |
| PROSITE | PS00237 PS50262 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0071502 |
cellular response to temperature stimulus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071312 |
cellular response to alkaloid |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051378 |
serotonin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042493 |
response to drug |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035690 |
cellular response to drug |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0014063 |
negative regulation of serotonin secretion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008144 |
drug binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007205 |
protein kinase C-activating G protein-coupled receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007198 |
adenylate cyclase-inhibiting serotonin receptor signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004993 |
G protein-coupled serotonin receptor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002031 |
G protein-coupled receptor internalization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0099154 |
serotonergic synapse |
ECO:0006003 |
electron microscopy evidence used in manual assertion |
C |
part_of:(UBERON:0001898) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0099056 |
integral component of presynaptic membrane |
ECO:0006003 |
electron microscopy evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
enables |
GO:0030594 |
neurotransmitter receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000664111 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030425 |
dendrite |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000664111 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007268 |
chemical synaptic transmission |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000664111 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007187 |
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000664111 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000037 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004993 |
G protein-coupled serotonin receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0004168 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000664111 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:2000300 |
regulation of synaptic vesicle exocytosis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2846 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1904707 |
positive regulation of vascular smooth muscle cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0099626 |
voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2846 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0099171 |
presynaptic modulation of chemical synaptic transmission |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2846 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0071312 |
cellular response to alkaloid |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0051967 |
negative regulation of synaptic transmission, glutamatergic |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2846 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0051378 |
serotonin binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2846 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0046849 |
bone remodeling |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1278315 |
P |
has_participant:(EMAPA:32782) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0045471 |
response to ethanol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2846 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0044305 |
calyx of Held |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2846 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0042756 |
drinking behavior |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2846 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0042220 |
response to cocaine |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2846 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0035690 |
cellular response to drug |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032229 |
negative regulation of synaptic transmission, GABAergic |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2846 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0014059 |
regulation of dopamine secretion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2846 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008144 |
drug binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2846 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0007631 |
feeding behavior |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2846 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0007268 |
chemical synaptic transmission |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2846 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0007198 |
adenylate cyclase-inhibiting serotonin receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007193 |
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2846 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004993 |
G protein-coupled serotonin receptor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004993 |
G protein-coupled serotonin receptor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2846 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0099509 |
regulation of presynaptic cytosolic calcium ion concentration |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0099626 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0099509 |
regulation of presynaptic cytosolic calcium ion concentration |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0099626 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1904707 |
positive regulation of vascular smooth muscle cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28222 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071312 |
cellular response to alkaloid |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28222 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035690 |
cellular response to drug |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28222 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007198 |
adenylate cyclase-inhibiting serotonin receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28222 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007193 |
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28222 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28222 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28222 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004993 |
G protein-coupled serotonin receptor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28222 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000300 |
regulation of synaptic vesicle exocytosis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28564 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0099626 |
voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28564 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0099171 |
presynaptic modulation of chemical synaptic transmission |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28564 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051967 |
negative regulation of synaptic transmission, glutamatergic |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28564 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051385 |
response to mineralocorticoid |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28564 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0051378 |
serotonin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28564 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045471 |
response to ethanol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28564 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0044305 |
calyx of Held |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28564 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042756 |
drinking behavior |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28564 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042220 |
response to cocaine |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28564 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032229 |
negative regulation of synaptic transmission, GABAergic |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28564 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0014059 |
regulation of dopamine secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28564 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008144 |
drug binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28564 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007631 |
feeding behavior |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28564 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007268 |
chemical synaptic transmission |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28564 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28564 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004993 |
G protein-coupled serotonin receptor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P28564 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:X5D7I5 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004993 |
G protein-coupled serotonin receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007268 |
chemical synaptic transmission |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042310 |
vasoconstriction |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046849 |
bone remodeling |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050795 |
regulation of behavior |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007610 |
behavior |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Janoshazi, A et al. (2007) Modified receptor internalization upon coexpression of 5-HT1B receptor and 5-HT2B receptors. Mol. Pharmacol. 71 1463-74 PubMed GONUTS page
- ↑ Trillat, AC et al. (1997) Regulation of serotonin release in the frontal cortex and ventral hippocampus of homozygous mice lacking 5-HT1B receptors: in vivo microdialysis studies. J. Neurochem. 69 2019-25 PubMed GONUTS page
- ↑ 3.0 3.1 Pickard, GE et al. (1999) 5-HT1B receptor-mediated presynaptic inhibition of retinal input to the suprachiasmatic nucleus. J. Neurosci. 19 4034-45 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Yadav, VK et al. (2008) Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell 135 825-37 PubMed GONUTS page
a
c
g
- Glires
- GO:0007186 ! G protein-coupled receptor signaling pathway
- GO:0002031 ! G protein-coupled receptor internalization
- GO:0004930 ! G protein-coupled receptor activity
- GO:0007187 ! G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- GO:0004993 ! G protein-coupled serotonin receptor activity
n
o
p
r
- GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration
- GO:0014059 ! regulation of dopamine secretion
- GO:0050795 ! regulation of behavior
- GO:2000300 ! regulation of synaptic vesicle exocytosis
- GO:0042493 ! response to drug
- GO:0042220 ! response to cocaine
- GO:0051385 ! response to mineralocorticoid
- GO:0045471 ! response to ethanol
- Rodentia