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MICEC:Q8KNE0

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Species (Taxon ID) Micromonospora echinospora (Micromonospora purpurea). (1877)
Gene Name(s) calG2 (ECO:0000313 with EMBL:AAM70348.1)
Protein Name(s) CalG2 (ECO:0000313 with EMBL:AAM70348.1)
External Links
UniProt Q8KNE0
EMBL AF497482
PDB 3IAA
3RSC
PDBsum 3IAA
3RSC
ProteinModelPortal Q8KNE0
CAZy GT1
EvolutionaryTrace Q8KNE0
GO GO:0016758
GO:0016999
InterPro IPR002213
IPR006326
PANTHER PTHR11926
Pfam PF00201
TIGRFAMs TIGR01426

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0016757

transferase activity, transferring glycosyl groups

PMID:21987796[1]

ECO:0000314

F

CalG2 is a glycosyltransferase from Micromonospora echinospora derived from the calicheamicin gene cluster. Structure of CalG2 was solved by X-ray crystallography. Fig 2 & 3 show the structure with bound substrate and the catalytic residues.

complete
CACAO 8736

GO:0016757

transferase activity, transferring glycosyl groups

PMID:18721755[2]

ECO:0000314

F

CalG2 is a glycosyltransferase from the calicheamicin gene cluster in the organism, Micromonospora echinospora.Function was characterized by HPLC (High Pressure Liquid Chromatography) and Mass spectrometry as shown in Fig 5.

complete
CACAO 8737

enables

GO:0016758

transferase activity, transferring hexosyl groups

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006326
InterPro:IPR007235

F

Seeded From UniProt

complete

involved_in

GO:0016999

antibiotic metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006326

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Chang, A et al. (2011) Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity. Proc. Natl. Acad. Sci. U.S.A. 108 17649-54 PubMed GONUTS page
  2. Zhang, C et al. (2008) Biochemical and structural insights of the early glycosylation steps in calicheamicin biosynthesis. Chem. Biol. 15 842-53 PubMed GONUTS page