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MICEC:Q8KNC3

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Species (Taxon ID) Micromonospora echinospora (Micromonospora purpurea). (1877)
Gene Name(s) calG4 (ECO:0000313 with EMBL:AAM70365.1)
Protein Name(s) CalG4 (ECO:0000313 with EMBL:AAM70365.1)
External Links
UniProt Q8KNC3
EMBL AF497482
PDB 3IA7
PDBsum 3IA7
ProteinModelPortal Q8KNC3
CAZy GT1
EvolutionaryTrace Q8KNC3
GO GO:0046872
GO:0016758
GO:0016999
GO:0030259
InterPro IPR004276
IPR002213
IPR006326
PANTHER PTHR11926
Pfam PF03033
PF00201
TIGRFAMs TIGR01426

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0016758

transferase activity, transferring hexosyl groups

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002213
InterPro:IPR006326

F

Seeded From UniProt

complete

GO:0016757

transferase activity, transferring glycosyl groups

PMID:21987796[1]

ECO:0000314

F

The structure of the Glycosyltransferase isolated from Micromonospora echinospora via X-ray crystallography. The gene for the Glycosyltransferase is located on the Calicheamicin gene cluster.Structure is shown in Fig 2C and 3C.

complete
CACAO 8925

involved_in

GO:0016999

antibiotic metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006326

P

Seeded From UniProt

complete

GO:0016757

transferase activity, transferring glycosyl groups

PMID:18721755[2]

ECO:0000314

F

Function of CalG4 was characterized by HPLC (in the reversible step between step 7 & 1), in Figure 6.

complete
CACAO 8928

enables

GO:0046872

metal ion binding

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Chang, A et al. (2011) Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity. Proc. Natl. Acad. Sci. U.S.A. 108 17649-54 PubMed GONUTS page
  2. Zhang, C et al. (2008) Biochemical and structural insights of the early glycosylation steps in calicheamicin biosynthesis. Chem. Biol. 15 842-53 PubMed GONUTS page