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MESAU:UCP1

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Species (Taxon ID) Mesocricetus auratus (Golden hamster). (10036)
Gene Name(s) UCP1 (synonyms: SLC25A7, UCP)
Protein Name(s) Mitochondrial brown fat uncoupling protein 1

UCP 1 Solute carrier family 25 member 7 Thermogenin

External Links
UniProt P04575
EMBL X73138
PIR S34268
RefSeq NP_001268261.1
ProteinModelPortal P04575
GeneID 101835783
CTD 7350
HOVERGEN HBG009528
GO GO:0016021
GO:0005743
GO:0006839
Gene3D 1.50.40.10
InterPro IPR002030
IPR018108
IPR023395
Pfam PF00153
PRINTS PR00784
SUPFAM SSF103506
PROSITE PS50920

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0006839

mitochondrial transport

PMID:10727223[1]

ECO:0000314

P

See Table 1

complete
CACAO 6253

part_of

GO:0005743

mitochondrial inner membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:W5PSH7

C

Seeded From UniProt

complete

enables

GO:1901612

cardiolipin binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:W5PSH7

F

Seeded From UniProt

complete

enables

GO:0032555

purine ribonucleotide binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12242

F

Seeded From UniProt

complete

enables

GO:0036041

long-chain fatty acid binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12242

F

Seeded From UniProt

complete

enables

GO:0017077

oxidative phosphorylation uncoupler activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12242

F

Seeded From UniProt

complete

involved_in

GO:1990542

mitochondrial transmembrane transport

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12242

P

Seeded From UniProt

complete

involved_in

GO:1903426

regulation of reactive oxygen species biosynthetic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12242

P

Seeded From UniProt

complete

involved_in

GO:0071398

cellular response to fatty acid

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12242

P

Seeded From UniProt

complete

involved_in

GO:0034614

cellular response to reactive oxygen species

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12242

P

Seeded From UniProt

complete

involved_in

GO:0032870

cellular response to hormone stimulus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12242

P

Seeded From UniProt

complete

involved_in

GO:0031667

response to nutrient levels

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12242

P

Seeded From UniProt

complete

involved_in

GO:1902600

proton transmembrane transport

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12242

P

Seeded From UniProt

complete

involved_in

GO:0009266

response to temperature stimulus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12242

P

Seeded From UniProt

complete

involved_in

GO:1990845

adaptive thermogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12242

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040011

C

Seeded From UniProt

complete

involved_in

GO:0006839

mitochondrial transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002030

P

Seeded From UniProt

complete

enables

GO:0017077

oxidative phosphorylation uncoupler activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040011

F

Seeded From UniProt

complete

enables

GO:0022857

transmembrane transporter activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040062

F

Seeded From UniProt

complete

part_of

GO:0031966

mitochondrial membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002030

C

Seeded From UniProt

complete

involved_in

GO:0071398

cellular response to fatty acid

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040011

P

Seeded From UniProt

complete

involved_in

GO:1990542

mitochondrial transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040011

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0406

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0999
UniProtKB-SubCell:SL-0168

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Echtay, KS et al. (2000) Site-directed mutagenesis identifies residues in uncoupling protein (UCP1) involved in three different functions. Biochemistry 39 3311-7 PubMed GONUTS page