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MEDSV:PP1

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Species (Taxon ID) Medicago sativa subsp. varia (Alfalfa) (Medicago varia). (36902)
Gene Name(s) PP1
Protein Name(s) Serine/threonine-protein phosphatase PP1
External Links
UniProt P48488
EMBL X80788
PIR S46282
ProteinModelPortal P48488
SMR P48488
PRIDE P48488
GO GO:0046872
GO:0004721
Gene3D 3.60.21.10
InterPro IPR004843
IPR029052
IPR006186
Pfam PF00149
PRINTS PR00114
SMART SM00156
SUPFAM SSF56300
PROSITE PS00125

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0019212

phosphatase inhibitor activity

PMID:22882676[1]

ECO:0000314

F

Figure 4: Zoledronic acid (ZA) caused inhibition of phosphatase 1 (PP1) and PP2A phosphatase activity in PC3 and DU145 cells.

complete
CACAO 5302

GO:0010447

response to acidity

PMID:22882676[1]

ECO:0000314

P

Figure 4: Zoledronic acid (ZA) caused inhibition of phosphatase 1 (PP1) and PP2A phosphatase activity in PC3 and DU145 cells.

complete
CACAO 5303

involved_in

GO:0006470

protein dephosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004721

P

Seeded From UniProt

complete

involved_in

GO:0006470

protein dephosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004721

P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004843
InterPro:IPR006186

F

Seeded From UniProt

complete

enables

GO:0004721

phosphoprotein phosphatase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.3.16

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0004721

phosphoprotein phosphatase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0904

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Cirak, Y et al. (2012) Zoledronic acid in combination with serine/threonine phosphatase inhibitors induces enhanced cytotoxicity and apoptosis in hormone-refractory prostate cancer cell lines by decreasing the activities of PP1 and PP2A. BJU Int. 110 E1147-54 PubMed GONUTS page