LISMO:TACY

Species (Taxon ID)	Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e). (169963)
Gene Name(s)	hly (synonyms: hlyA, lisA)
Protein Name(s)	Listeriolysin O LLO Thiol-activated cytolysin
External Links
UniProt	P13128
EMBL	X15127 M24199 X60035 U25446 U25449 U25452 AL591974
PIR	A43505 AC1100 S24231
RefSeq	NP_463733.1 WP_003722731.1 YP_008294942.1
PDB	4CDB
PDBsum	4CDB
ProteinModelPortal	P13128
IntAct	P13128
MINT	MINT-8216036
STRING	169963.lmo0202
TCDB	1.C.12.1.7
EnsemblBacteria	CAD00729
GeneID	16332018 987033
KEGG	lmo:lmo0202
PATRIC	20309411
GenoList	LMO0202
eggNOG	NOG04845
KO	K11031
OMA	THKTWDG
OrthoDB	EOG6S7XT6
BioCyc	LMON169963:LMO0202-MONOMER
Proteomes	UP000000817
GO	GO:0020002 GO:0016021 GO:0015485 GO:0042802 GO:0044179 GO:0009405
Gene3D	3.90.840.10
InterPro	IPR001869
Pfam	PF01289
PRINTS	PR01400
SUPFAM	SSF56978
PROSITE	PS00481

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0044179	hemolysis of cells in other organism	PMID:3110067	ECO:0000314			P		Fig 3. Lytic activity	complete
	GO:0044179	hemolysis of cells in other organism	PMID:2509366	ECO:0000315			P		Table 1. Hemolysis reduced in mutant phenotype	complete
	GO:0009405	pathogenesis	PMID:2509366	ECO:0000315			P		Fig. 4 Virulence reduced in mutant phenotype	complete
	GO:0019836	hemolysis by symbiont of host erythrocytes	PMID:3110067	ECO:0000314			P		Table 2 shows that mice injected with LLO died due to hemolysis. However, when cholesterol, heat, or N-ethylmaleimide blocked the LLO activity the mice lived.	complete CACAO 7395
enables	GO:0042802	identical protein binding	PMID:22023160	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P13128	F		Seeded From UniProt	complete
involved_in	GO:0009405	pathogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001869 InterPro:IPR036359 InterPro:IPR036363	P		Seeded From UniProt	complete
enables	GO:0015485	cholesterol binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001869 InterPro:IPR036359 InterPro:IPR036363	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0033644	host cell membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1043 UniProtKB-SubCell:SL-0380	C		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F		Seeded From UniProt	complete
part_of	GO:0020002	host cell plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1032 UniProtKB-SubCell:SL-0375	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0090729	toxin activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0800	F		Seeded From UniProt	complete
involved_in	GO:0009405	pathogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0843	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0019835	cytolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0204	P		Seeded From UniProt	complete
involved_in	GO:0044179	hemolysis in other organism	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0354	P		Seeded From UniProt	complete
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References

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