LEPIR:Q93MT8

Species (Taxon ID)	Leptospira interrogans. (173)
Gene Name(s)	chpK (ECO:0000313 with EMBL:AAK82420.1)
Protein Name(s)	mRNA interferase (ECO:0000256 with PIRNR:PIRNR033490)
External Links
UniProt	Q93MT8
EMBL	AF395875
RefSeq	WP_000617906.1
EnsemblBacteria	KWV24431
PATRIC	fig|173.13.peg.2614
eggNOG	ENOG41081UW COG2337
HOGENOM	HOG000290184
GO	GO:0003677 GO:0004519
Gene3D	2.30.30.110
InterPro	IPR003477 IPR011067
PANTHER	PTHR33988
Pfam	PF02452
PIRSF	PIRSF033490

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004519	P		Seeded From UniProt
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004518	P		Seeded From UniProt
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003477	F		Seeded From UniProt
enables	GO:0016787	hydrolase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt
enables	GO:0004519	endonuclease activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0255	F		Seeded From UniProt
enables	GO:0004518	nuclease activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0540	F		Seeded From UniProt
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004519	P		Seeded From UniProt
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004518	P		Seeded From UniProt
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003477	F		Seeded From UniProt
enables	GO:0016787	hydrolase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt
enables	GO:0004519	endonuclease activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0255	F		Seeded From UniProt
enables	GO:0004518	nuclease activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0540	F		Seeded From UniProt
	GO:0110001	toxin-antitoxin complex	PMID:25461800	ECO:0001258			C		Figure 1B show growth curves, in which OD600 reflect the number of E. coli in cultures incubated. ChpK, also called mRNA interferase, is a toxin in Leptospira interrogans that allows increase in OD600 as long as its expressed alongside the antoxin ChpI that neutralizes the toxin. If ChpK is expressed without the ChpI, the toxicity of ChpK will cause the OD600 value to decrease.	complete CACAO 13598
	GO:0001907	killing by symbiont of host cells	PMID:25461800	ECO:0005034			P		Fig. 3 shows that ChpK from Leptospira interrogans is involved in inducing necrotic death of the THP-1 host cell.	complete CACAO 13641
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References

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