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LAMBD:RPC1

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Species (Taxon ID) Escherichia phage lambda (Bacteriophage lambda). (10710)
Gene Name(s) cI
Protein Name(s) Repressor protein cI
External Links
UniProt P03034
EMBL J02459
X00166
PIR A14086
RefSeq NP_040628.1
PDB 1F39
1GFX
1J5G
1KCA
1LLI
1LMB
1LRP
1LWQ
1RIO
3BDN
3KZ3
3WOA
PDBsum 1F39
1GFX
1J5G
1KCA
1LLI
1LMB
1LRP
1LWQ
1RIO
3BDN
3KZ3
3WOA
ProteinModelPortal P03034
SMR P03034
DIP DIP-17006N
IntAct P03034
MEROPS S24.002
GeneID 2703537
KEGG vg:3827059
EvolutionaryTrace P03034
Proteomes UP000001711
GO GO:0043565
GO:0006355
GO:0006351
Gene3D 1.10.260.40
2.10.109.10
InterPro IPR001387
IPR010982
IPR028360
IPR019759
IPR015927
Pfam PF01381
PF00717
SMART SM00530
SUPFAM SSF47413
SSF51306
PROSITE PS50943

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0017053

transcriptional repressor complex

PMID:23853547[1]

ECO:0000314

C

Figure 5 shows that there is a direct relationship between DNA looping and CI levels. This demonstrates how CI is a repressor protein.

complete
CACAO 9962

part_of

GO:0019012

virion

PMID:17908932[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0019044

maintenance of viral latency

PMID:17908932[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010944

negative regulation of transcription by competitive promoter binding

PMID:17908932[2]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P03034)

Seeded From UniProt

complete

involved_in

GO:0050434

positive regulation of viral transcription

PMID:17908932[2]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P03034)

Seeded From UniProt

complete

enables

GO:0001047

core promoter binding

PMID:17908932[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:21943085[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P03034

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:18432246[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P03034

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010982

F

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001387

F

Seeded From UniProt

complete

involved_in

GO:0019042

viral latency

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1251

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0098689

latency-replication decision

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1252

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Hensel, Z et al. (2013) Transcription-factor-mediated DNA looping probed by high-resolution, single-molecule imaging in live E. coli cells. PLoS Biol. 11 e1001591 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Schubert, RA et al. (2007) Cro's role in the CI Cro bistable switch is critical for {lambda}'s transition from lysogeny to lytic development. Genes Dev. 21 2461-72 PubMed GONUTS page
  3. Rajagopala, SV et al. (2011) The protein interaction map of bacteriophage lambda. BMC Microbiol. 11 213 PubMed GONUTS page
  4. Stayrook, S et al. (2008) Crystal structure of the lambda repressor and a model for pairwise cooperative operator binding. Nature 452 1022-5 PubMed GONUTS page