LACRD:A5VK67

Species (Taxon ID)	Lactobacillus reuteri (strain DSM 20016). (557436)
Gene Name(s)	No Information Provided.
Protein Name(s)	Uncharacterized protein (ECO:0000313 with EMBL:ABQ83241.1)
External Links
UniProt	A5VK67
EMBL	CP000705
RefSeq	WP_003667770.1
ProteinModelPortal	A5VK67
EnsemblBacteria	ABQ83241
GeneID	5189132
KEGG	lre:Lreu_0980
PATRIC	fig|557436.17.peg.1766
HOGENOM	HOG000288801
OMA	IGFFVWH
BioCyc	LREU557436:G1G8Z-1041-MONOMER
Proteomes	UP000001991
GO	GO:0016021

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045893	positive regulation of transcription, DNA-templated	PMID:24123819	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Fig. 1A: hdc gene expression decreased in rsiR mutants Fig 2: culture supernatants from wildtype had higher concentrations of histamine than culture supernatants from rsiR mutant	complete CACAO 9608
part_of	GO:0016020	membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt
	GO:0046775	suppression by virus of host cytokine production	PMID:24123819	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Figure 4: wild-type suppressed production of human TNF, mutant rsiR less effective at suppressing production of TNF	complete CACAO 9663
part_of	GO:0016021	integral component of membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt
	GO:0001694	histamine biosynthetic process	PMID:24123819	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Fig. 2: production of histamine was much higher in wildtype than mutant, even in presence of L-histidine (Lactobacillus reuteri converts L-histidine to histamine)	complete CACAO 10052
part_of	GO:0016020	membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt
part_of	GO:0016021	integral component of membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt
	GO:0052036	negative regulation by symbiont of host inflammatory response	PMID:24123819	ECO:0000315	mutant phenotype evidence used in manual assertion		P		TNBS was injected in mice to induce intestinal inflammation Fig. 5A: mice pretreated with wildtype supernatant experienced less inflammation than mice pretreated with mutant supernatant Fig. 5B: mice pretreated with wildtype supernatant produced less SAA than mice pretreated with mutant supernatant (SAA is secreted during the initial stages of inflammation)	complete CACAO 10069
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References

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