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KLEPN:BLAN1
Contents
| Species (Taxon ID) | Klebsiella pneumoniae. (573) | |
| Gene Name(s) | blaNDM-1 | |
| Protein Name(s) | Beta-lactamase NDM-1
NDM-1 Metallo-beta-lactamase NDM-1 | |
| External Links | ||
| UniProt | C7C422 | |
| EMBL | FN396876 | |
| RefSeq | YP_005352173.1 YP_006958736.1 YP_006959150.1 YP_006959255.1 YP_006959318.1 YP_007195502.1 YP_007641427.1 YP_007936899.1 YP_008719663.1 YP_009023060.1 YP_009066437.1 YP_009071638.1 YP_009082638.1 YP_009083148.1 YP_009089162.1 YP_009090736.1 YP_009090740.1 YP_009090902.1 YP_009091191.1 | |
| PDB | 3PG4 3Q6X 3RKJ 3RKK 3SBL 3SFP 3SPU 3SRX 3ZR9 4EXS 4EXY 4EY2 4EYB 4EYF 4EYL 4GYQ 4GYU 4H0D 4HKY 4HL1 4HL2 4RAM 4U4L | |
| PDBsum | 3PG4 3Q6X 3RKJ 3RKK 3SBL 3SFP 3SPU 3SRX 3ZR9 4EXS 4EXY 4EY2 4EYB 4EYF 4EYL 4GYQ 4GYU 4H0D 4HKY 4HL1 4HL2 4RAM 4U4L | |
| ProteinModelPortal | C7C422 | |
| ChEMBL | CHEMBL1667695 | |
| GeneID | 11934636 13913959 13914060 13914125 13914405 14258327 14858116 15407950 17373266 18983573 20471925 20494087 | |
| EvolutionaryTrace | C7C422 | |
| GO | GO:0042597 GO:0008800 GO:0046872 GO:0046677 | |
| Gene3D | 3.60.15.10 | |
| InterPro | IPR001279 | |
| Pfam | PF00753 | |
| SMART | SM00849 | |
| SUPFAM | SSF56281 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0046677 |
response to antibiotic |
ECO:0000314 |
P |
Table 1: bla(NDM-1) from K. pneumoniae was inserted into E. coli strains, conferring resistance to several antibiotics. |
complete | |||||
| GO:0008800 |
beta-lactamase activity |
ECO:0000314 |
F |
Table 2 compares NDM-1's antibiotic kinetics to other metallo beta-lactamases in K. pneumoniae and shows that the New Delhi metallo beta-lactamase has very little in common comparatively to the other MBLs. Specifically that NDM-1 shows higher affinity for cephalosporins than IMP-1 and VIM-2 given by its lower Km value. |
complete | |||||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008800 |
beta-lactamase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0017001 |
antibiotic catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008800 |
beta-lactamase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042597 |
periplasmic space |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046677 |
response to antibiotic |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Yong, D et al. (2009) Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Antimicrob. Agents Chemother. 53 5046-54 PubMed GONUTS page
- ↑ Klingler, FM et al. (2015) Approved Drugs Containing Thiols as Inhibitors of Metallo-β-lactamases: Strategy To Combat Multidrug-Resistant Bacteria. J. Med. Chem. 58 3626-30 PubMed GONUTS page
- ↑ King, DT et al. (2012) New Delhi metallo-β-lactamase: structural insights into β-lactam recognition and inhibition. J. Am. Chem. Soc. 134 11362-5 PubMed GONUTS page
