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HUMAN:ZP2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | ZP2 (synonyms: ZPA) | |
| Protein Name(s) | Zona pellucida sperm-binding protein 2
Zona pellucida glycoprotein 2 Zp-2 Zona pellucida protein A Processed zona pellucida sperm-binding protein 2 | |
| External Links | ||
| UniProt | Q05996 | |
| EMBL | M90366 AK313003 AF001550 CH471228 BC096304 BC096305 BC096306 BC096307 | |
| CCDS | CCDS10596.1 CCDS73843.1 | |
| PIR | A48833 | |
| RefSeq | NP_001277033.1 NP_003451.1 | |
| UniGene | Hs.73982 | |
| ProteinModelPortal | Q05996 | |
| SMR | Q05996 | |
| IntAct | Q05996 | |
| MINT | MINT-7241855 | |
| STRING | 9606.ENSP00000219593 | |
| PhosphoSite | Q05996 | |
| DMDM | 466206 | |
| PaxDb | Q05996 | |
| PRIDE | Q05996 | |
| Ensembl | ENST00000574002 ENST00000574091 | |
| GeneID | 7783 | |
| KEGG | hsa:7783 | |
| UCSC | uc002dii.2 uc010bwn.1 | |
| CTD | 7783 | |
| GeneCards | GC16M021208 | |
| HGNC | HGNC:13188 | |
| HPA | HPA011296 | |
| MIM | 182888 | |
| neXtProt | NX_Q05996 | |
| PharmGKB | PA37756 | |
| eggNOG | NOG41554 | |
| GeneTree | ENSGT00530000063096 | |
| HOGENOM | HOG000059563 | |
| HOVERGEN | HBG004379 | |
| InParanoid | Q05996 | |
| OMA | DDCWATS | |
| PhylomeDB | Q05996 | |
| TreeFam | TF332794 | |
| Reactome | REACT_163933 | |
| GeneWiki | ZP2 | |
| GenomeRNAi | 7783 | |
| NextBio | 30133 | |
| PRO | PR:Q05996 | |
| Proteomes | UP000005640 | |
| Bgee | Q05996 | |
| CleanEx | HS_ZP2 | |
| Genevestigator | Q05996 | |
| GO | GO:0005783 GO:0031012 GO:0005576 GO:0005794 GO:0016021 GO:0005771 GO:0005886 GO:0005578 GO:0030141 GO:0032190 GO:0015026 GO:0007339 GO:0006886 GO:0032504 GO:0060468 GO:0007165 GO:0007338 | |
| InterPro | IPR001507 IPR017977 | |
| Pfam | PF00100 | |
| PRINTS | PR00023 | |
| SMART | SM00241 | |
| PROSITE | PS00682 PS51034 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0060468 |
prevention of polyspermy |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
NOT|involved_in |
GO:0060046 |
regulation of acrosome reaction |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
NOT|involved_in |
GO:0060046 |
regulation of acrosome reaction |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0032190 |
acrosin binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007339 |
binding of sperm to zona pellucida |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005771 |
multivesicular body |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P20239 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060468 |
prevention of polyspermy |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P20239 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007339 |
binding of sperm to zona pellucida |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P20239 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P20239 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P20239 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005771 |
multivesicular body |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P20239 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0015026 |
coreceptor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007339 |
binding of sperm to zona pellucida |
PMID:8385033[6] |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-1297338 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007338 |
single fertilization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Burkart, AD et al. (2012) Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy. J. Cell Biol. 197 37-44 PubMed GONUTS page
- ↑ Bray, C et al. (2002) A role for the human sperm glycine receptor/Cl(-) channel in the acrosome reaction initiated by recombinant ZP3. Biol. Reprod. 66 91-7 PubMed GONUTS page
- ↑ José, O et al. (2010) Recombinant human ZP3-induced sperm acrosome reaction: evidence for the involvement of T- and L-type voltage-gated calcium channels. Biochem. Biophys. Res. Commun. 395 530-4 PubMed GONUTS page
- ↑ Furlong, LI et al. (2005) Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC. Fertil. Steril. 83 1780-90 PubMed GONUTS page
- ↑ Louros, NN et al. (2016) A common 'aggregation-prone' interface possibly participates in the self-assembly of human zona pellucida proteins. FEBS Lett. 590 619-30 PubMed GONUTS page
- ↑ 6.0 6.1 Liang, LF & Dean, J (1993) Conservation of mammalian secondary sperm receptor genes enables the promoter of the human gene to function in mouse oocytes. Dev. Biol. 156 399-408 PubMed GONUTS page
