HUMAN:XRP2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	RP2
Protein Name(s)	Protein XRP2
External Links
UniProt	O75695
EMBL	AJ007590 AL050307 AL627143 BC043348 BC053530
CCDS	CCDS14270.1
RefSeq	NP_008846.2
UniGene	Hs.44766
PDB	2BX6 3BH6 3BH7
PDBsum	2BX6 3BH6 3BH7
ProteinModelPortal	O75695
SMR	O75695
BioGrid	112029
DIP	DIP-29024N
IntAct	O75695
MINT	MINT-5003911
STRING	9606.ENSP00000218340
PhosphoSite	O75695
MaxQB	O75695
PaxDb	O75695
PeptideAtlas	O75695
PRIDE	O75695
DNASU	6102
Ensembl	ENST00000218340
GeneID	6102
KEGG	hsa:6102
UCSC	uc004dgw.4
CTD	6102
GeneCards	GC0XP046696
GeneReviews	RP2
H-InvDB	HIX0016754
HGNC	HGNC:10274
HPA	HPA000234
MIM	300757 312600
neXtProt	NX_O75695
Orphanet	791
PharmGKB	PA34641
eggNOG	NOG326369
GeneTree	ENSGT00530000063741
HOGENOM	HOG000007790
HOVERGEN	HBG054784
InParanoid	O75695
KO	K18272
OMA	QWYYPEL
OrthoDB	EOG7ZPNKQ
PhylomeDB	O75695
TreeFam	TF105832
EvolutionaryTrace	O75695
GeneWiki	RP2_(gene)
GenomeRNAi	6102
NextBio	23737
PRO	PR:O75695
Proteomes	UP000005640
Bgee	O75695
CleanEx	HS_RP2
Genevestigator	O75695
GO	GO:0005814 GO:0036064 GO:0005737 GO:0031410 GO:0070062 GO:0005794 GO:1990075 GO:0005886 GO:0005524 GO:0005525 GO:0005096 GO:0004550 GO:0051082 GO:0000902 GO:0006241 GO:0007010 GO:0006183 GO:0043547 GO:0006892 GO:0006457 GO:0015031 GO:0006228 GO:0007601
Gene3D	2.160.20.70
InterPro	IPR013912 IPR017901 IPR016098 IPR006599 IPR001564 IPR017332 IPR012945
PANTHER	PTHR15440:SF0
Pfam	PF07986
PIRSF	PIRSF037947
SMART	SM00673
SUPFAM	SSF54919 SSF69340
PROSITE	PS51329

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0000287	magnesium ion binding	PMID:26455799^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	PMID:26455799^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(UniProtKB:Q9WUL7)	Seeded From UniProt	complete
part_of	GO:0036064	ciliary basal body	PMID:26455799^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
NOT\|involved_in	GO:0007023	post-chaperonin tubulin folding pathway	PMID:11847227^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:12417528^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12417528^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	PMID:18376416^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	PMID:11847227^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0036064	ciliary basal body	PMID:20106869^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:20106869^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P36405	C		Seeded From UniProt	complete
involved_in	GO:0006892	post-Golgi vesicle-mediated transport	PMID:20106869^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P36405	P		Seeded From UniProt	complete
involved_in	GO:0006892	post-Golgi vesicle-mediated transport	PMID:20106869^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:20106869^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005096	P		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005096	P		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005096	P		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005096	P		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005096	P		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005096	P		Seeded From UniProt	complete
part_of	GO:1990075	periciliary membrane compartment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK2 ensembl:ENSMUSP00000033372	C		Seeded From UniProt	complete
part_of	GO:0036064	ciliary basal body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK2 ensembl:ENSMUSP00000033372	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK2 ensembl:ENSMUSP00000033372	C		Seeded From UniProt	complete
part_of	GO:0005814	centriole	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK2 ensembl:ENSMUSP00000033372	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPK2 ensembl:ENSMUSP00000033372	C		Seeded From UniProt	complete
involved_in	GO:0000902	cell morphogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016098	P		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039093	F		Seeded From UniProt	complete
enables	GO:0051082	unfolded protein binding	PMID:9697692^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007601	visual perception	PMID:9697692^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006457	protein folding	PMID:9697692^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	Reactome:R-HSA-5638016 Reactome:R-HSA-5638007 Reactome:R-HSA-5638006 Reactome:R-HSA-5638004	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	Reactome:R-HSA-5638007	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653	P		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0342	F		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0343	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0969 UniProtKB-SubCell:SL-0066	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Lokaj, M et al. (2015) The Interaction of CCDC104/BARTL1 with Arl3 and Implications for Ciliary Function. Structure 23 2122-32 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ ^5.0 ^5.1 Bartolini, F et al. (2002) Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C. J. Biol. Chem. 277 14629-34 PubMed GONUTS page
↑ ^6.0 ^6.1 Grayson, C et al. (2002) Localization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3. Hum. Mol. Genet. 11 3065-74 PubMed GONUTS page
↑ Veltel, S et al. (2008) The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3. Nat. Struct. Mol. Biol. 15 373-80 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Evans, RJ et al. (2010) The retinitis pigmentosa protein RP2 links pericentriolar vesicle transport between the Golgi and the primary cilium. Hum. Mol. Genet. 19 1358-67 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Schwahn, U et al. (1998) Positional cloning of the gene for X-linked retinitis pigmentosa 2. Nat. Genet. 19 327-32 PubMed GONUTS page

[PMID:26455799-1] 1.0 ^1.1 ^1.2 Lokaj, M et al. (2015) The Interaction of CCDC104/BARTL1 with Arl3 and Implications for Ciliary Function. Structure 23 2122-32 PubMed GONUTS page

[PMID:23533145-2] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19056867-3] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:20458337-4] Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:11847227-5] 5.0 ^5.1 Bartolini, F et al. (2002) Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C. J. Biol. Chem. 277 14629-34 PubMed GONUTS page

[PMID:12417528-6] 6.0 ^6.1 Grayson, C et al. (2002) Localization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3. Hum. Mol. Genet. 11 3065-74 PubMed GONUTS page

[PMID:18376416-7] Veltel, S et al. (2008) The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3. Nat. Struct. Mol. Biol. 15 373-80 PubMed GONUTS page

[PMID:20106869-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Evans, RJ et al. (2010) The retinitis pigmentosa protein RP2 links pericentriolar vesicle transport between the Golgi and the primary cilium. Hum. Mol. Genet. 19 1358-67 PubMed GONUTS page

[PMID:9697692-9] 9.0 ^9.1 ^9.2 Schwahn, U et al. (1998) Positional cloning of the gene for X-linked retinitis pigmentosa 2. Nat. Genet. 19 327-32 PubMed GONUTS page

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HUMAN:XRP2

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