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HUMAN:WFDC2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | WFDC2 (synonyms: HE4, WAP5) | |
| Protein Name(s) | WAP four-disulfide core domain protein 2
Epididymal secretory protein E4 Major epididymis-specific protein E4 Putative protease inhibitor WAP5 | |
| External Links | ||
| UniProt | Q14508 | |
| EMBL | X63187 AF330259 AF330260 AF330261 AF330262 AY212888 CR456977 AL031663 AL031663 AL031663 AL031663 CH471077 CH471077 CH471077 BC046106 | |
| CCDS | CCDS35501.1 | |
| PIR | S25454 | |
| RefSeq | NP_006094.3 | |
| UniGene | Hs.2719 | |
| ProteinModelPortal | Q14508 | |
| SMR | Q14508 | |
| BioGrid | 115677 | |
| IntAct | Q14508 | |
| MINT | MINT-1429295 | |
| MEROPS | I17.004 | |
| DMDM | 20141958 | |
| MaxQB | Q14508 | |
| PaxDb | Q14508 | |
| PeptideAtlas | Q14508 | |
| PRIDE | Q14508 | |
| DNASU | 10406 | |
| Ensembl | ENST00000217425 ENST00000339946 ENST00000342873 ENST00000372676 | |
| GeneID | 10406 | |
| KEGG | hsa:10406 | |
| UCSC | uc002xoo.3 uc002xop.3 uc002xor.3 | |
| CTD | 10406 | |
| GeneCards | GC20P044098 | |
| HGNC | HGNC:15939 | |
| HPA | HPA042302 | |
| neXtProt | NX_Q14508 | |
| PharmGKB | PA38059 | |
| eggNOG | NOG27860 | |
| GeneTree | ENSGT00730000111410 | |
| HOVERGEN | HBG018073 | |
| InParanoid | Q14508 | |
| OMA | CSIPNEK | |
| OrthoDB | EOG7S7SG9 | |
| PhylomeDB | Q14508 | |
| ChiTaRS | WFDC2 | |
| GeneWiki | WFDC2 | |
| GenomeRNAi | 10406 | |
| NextBio | 39431 | |
| PRO | PR:Q14508 | |
| Proteomes | UP000005640 | |
| Bgee | Q14508 | |
| CleanEx | HS_WFDC2 | |
| ExpressionAtlas | Q14508 | |
| Genevestigator | Q14508 | |
| GO | GO:0005615 GO:0070062 GO:0019828 GO:0004869 GO:0004866 GO:0004867 GO:0010951 GO:0006508 GO:0007283 | |
| Gene3D | 4.10.75.10 | |
| InterPro | IPR008197 | |
| Pfam | PF00095 | |
| PRINTS | PR00003 | |
| SMART | SM00217 | |
| SUPFAM | SSF57256 | |
| PROSITE | PS51390 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0004867 |
serine-type endopeptidase inhibitor activity |
ECO:0000314 |
F |
Figure 4. A)Percentage inhibition of various proteases like: trypsin, chymottrypsin, PSA, proteinase K, pepsin and papain by HE-4. Graph shows a direct relationship with serine proteases. |
complete | |||||
| GO:0019828 |
aspartic-type endopeptidase inhibitor activity |
ECO:0000314 |
F |
Figure 4. A)Percentage inhibition of various proteases like: trypsin, chymottrypsin, PSA, proteinase K, pepsin and papain by HE-4. Graph shows a direct relationship with aspartic proteases. |
complete | |||||
|
enables |
GO:0019828 |
aspartic-type endopeptidase inhibitor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004867 |
serine-type endopeptidase inhibitor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010951 |
negative regulation of endopeptidase activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004866 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010951 |
negative regulation of endopeptidase activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0019828 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010951 |
negative regulation of endopeptidase activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0019828 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010951 |
negative regulation of endopeptidase activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004867 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010951 |
negative regulation of endopeptidase activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004869 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030414 |
peptidase inhibitor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007283 |
spermatogenesis |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004866 |
endopeptidase inhibitor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004867 |
serine-type endopeptidase inhibitor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019828 |
aspartic-type endopeptidase inhibitor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010466 |
negative regulation of peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030414 |
peptidase inhibitor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004869 |
cysteine-type endopeptidase inhibitor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Chhikara, N et al. (2012) Human epididymis protein-4 (HE-4): a novel cross-class protease inhibitor. PLoS ONE 7 e47672 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Kirchhoff, C et al. (1991) A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors. Biol. Reprod. 45 350-7 PubMed GONUTS page
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