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HUMAN:ULK3

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) ULK3
Protein Name(s) Serine/threonine-protein kinase ULK3

Unc-51-like kinase 3

External Links
UniProt Q6PHR2
EMBL AK294245
AK299380
AL117482
AC091230
BC036117
BC056423
CH471136
CH471136
BC157884
AL360256
CCDS CCDS45305.1
CCDS76779.1
PIR T17265
RefSeq NP_001092906.3
NP_001271293.2
NP_001271294.1
XP_005254346.1
UniGene Hs.513034
PDB 4WZX
PDBsum 4WZX
ProteinModelPortal Q6PHR2
SMR Q6PHR2
BioGrid 117470
IntAct Q6PHR2
STRING 9606.ENSP00000400312
BindingDB Q6PHR2
ChEMBL CHEMBL5047
GuidetoPHARMACOLOGY 2273
iPTMnet Q6PHR2
PhosphoSitePlus Q6PHR2
DMDM 259016166
EPD Q6PHR2
MaxQB Q6PHR2
PaxDb Q6PHR2
PeptideAtlas Q6PHR2
PRIDE Q6PHR2
DNASU 25989
Ensembl ENST00000440863
ENST00000568667
ENST00000569437
GeneID 25989
KEGG hsa:25989
UCSC uc010ulq.3
uc059llp.1
CTD 25989
DisGeNET 25989
EuPathDB HostDB:ENSG00000140474.12
GeneCards ULK3
H-InvDB HIX0012431
HGNC HGNC:19703
HPA HPA040474
MIM 613472
neXtProt NX_Q6PHR2
OpenTargets ENSG00000140474
PharmGKB PA134908392
eggNOG KOG0595
ENOG410XR01
GeneTree ENSGT00900000140878
HOGENOM HOG000233016
HOVERGEN HBG094133
InParanoid Q6PHR2
KO K21358
OMA YEVDAQR
OrthoDB EOG091G0JGC
PhylomeDB Q6PHR2
TreeFam TF324551
BRENDA 2.7.11.1
Reactome R-HSA-5632684
SignaLink Q6PHR2
GenomeRNAi 25989
PRO PR:Q6PHR2
Proteomes UP000005640
Bgee ENSG00000140474
CleanEx HS_ULK3
ExpressionAtlas Q6PHR2
Genevisible Q6PHR2
GO GO:0097542
GO:0005737
GO:0000407
GO:0005524
GO:0004674
GO:0006914
GO:0090398
GO:0045879
GO:0045880
GO:0046777
InterPro IPR011009
IPR007330
IPR036181
IPR000719
IPR017441
IPR008271
Pfam PF04212
PF00069
SMART SM00745
SM00220
SUPFAM SSF116846
SSF56112
PROSITE PS00107
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0072537

fibroblast activation

PMID:28877478[1]

ECO:0000315

P

Figure 3BC

complete
CACAO 13071

involved_in

GO:0046777

protein autophosphorylation

PMID:20643644[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046777

protein autophosphorylation

PMID:19878745[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045880

positive regulation of smoothened signaling pathway

PMID:20643644[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045880

positive regulation of smoothened signaling pathway

PMID:19878745[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045879

negative regulation of smoothened signaling pathway

PMID:20643644[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:19878745[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:20643644[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:19878745[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0046777

protein autophosphorylation

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0260945
MGI:MGI:1270126
PANTHER:PTN000681272
SGD:S000003148
UniProtKB:O75385
UniProtKB:Q6PHR2
UniProtKB:Q8IYT8
WB:WBGene00006786
dictyBase:DDB_G0292390

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1270126
PANTHER:PTN000681272

C

Seeded From UniProt

complete

involved_in

GO:0010506

regulation of autophagy

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0260945
PANTHER:PTN000681272

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1270126
PANTHER:PTN000681272
SGD:S000003148
UniProtKB:O75385

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0260945
MGI:MGI:1270126
MGI:MGI:1352758
PANTHER:PTN000681272
SGD:S000003148
UniProtKB:O75385
UniProtKB:Q6PHR2
UniProtKB:Q8IYT8

F

Seeded From UniProt

complete

part_of

GO:0000407

phagophore assembly site

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1270126
PANTHER:PTN000681272
PomBase:SPCC63.08c
SGD:S000003148

C

Seeded From UniProt

complete

involved_in

GO:0000045

autophagosome assembly

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1270126
PANTHER:PTN000681272
SGD:S000003148

P

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR017441

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

P

Seeded From UniProt

complete

involved_in

GO:0090398

cellular senescence

PMID:19279323[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006914

autophagy

PMID:19279323[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0000407

phagophore assembly site

PMID:19279323[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0097542

ciliary tip

Reactome:R-HSA-5635842
Reactome:R-HSA-5635839

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

Reactome:R-HSA-5635842

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

involved_in

GO:0006914

autophagy

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0072

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Goruppi, S et al. (2017) The ULK3 Kinase Is Critical for Convergent Control of Cancer-Associated Fibroblast Activation by CSL and GLI. Cell Rep 20 2468-2479 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Maloverjan, A et al. (2010) Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway. J. Biol. Chem. 285 30079-90 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Maloverjan, A et al. (2010) Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway. Exp. Cell Res. 316 627-37 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Young, AR et al. (2009) Autophagy mediates the mitotic senescence transition. Genes Dev. 23 798-803 PubMed GONUTS page
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