HUMAN:UD14

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	UGT1A4 (synonyms: GNT1, UGT1)
Protein Name(s)	UDP-glucuronosyltransferase 1-4 UDPGT 1-4 UGT1*4 UGT1-04 UGT1.4 Bilirubin-specific UDPGT isozyme 2 hUG-BR2 UDP-glucuronosyltransferase 1-D UGT-1D UGT1D UDP-glucuronosyltransferase 1A4
External Links
UniProt	P22310
EMBL	M84128 M84124 M84122 M84123 M57951 AF297093 AY435139 AK313623 DQ364249 AC006985 AC114812 CH471063 BC139784
CCDS	CCDS33405.1
RefSeq	NP_009051.1
UniGene	Hs.554822
ProteinModelPortal	P22310
SMR	P22310
BioGrid	120086
IntAct	P22310
STRING	9606.ENSP00000362508
ChEMBL	CHEMBL3619
DrugBank	DB06216 DB00363 DB04953 DB00555 DB00683 DB00910 DB00675 DB00831 DB00313
CAZy	GT1
PhosphoSite	P22310
DMDM	136731
PaxDb	P22310
PRIDE	P22310
Ensembl	ENST00000373409 ENST00000450233
GeneID	54657
KEGG	hsa:54657
UCSC	uc002vux.3
CTD	54657
GeneCards	GC02P234627
HGNC	HGNC:12536
MIM	143500 191740 218800 606429 606785
neXtProt	NX_P22310
PharmGKB	PA37179
eggNOG	COG1819
GeneTree	ENSGT00760000118949
HOGENOM	HOG000220832
HOVERGEN	HBG004033
InParanoid	P22310
KO	K00699
OMA	IFPCGAV
OrthoDB	EOG78H3T2
PhylomeDB	P22310
TreeFam	TF315472
BioCyc	MetaCyc:HS11970-MONOMER
BRENDA	2.4.1.17
Reactome	REACT_22297 REACT_6784
SABIO-RK	P22310
GeneWiki	UGT1A4
GenomeRNAi	54657
NextBio	35481512
PRO	PR:P22310
Proteomes	UP000005640
Bgee	P22310
ExpressionAtlas	P22310
Genevestigator	P22310
GO	GO:0005783 GO:0005789 GO:0016021 GO:0019899 GO:0015020 GO:0046982 GO:0042803 GO:0052695 GO:0044281 GO:0006805
InterPro	IPR002213
PANTHER	PTHR11926
Pfam	PF00201
PROSITE	PS00375

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0052695	cellular glucuronidation	PMID:22579593^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:17179145^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(GO:0005783) has_direct_input:(UniProtKB:P22309)	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:17179145^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(GO:0005783)	Seeded From UniProt	complete
enables	GO:0015020	glucuronosyltransferase activity	PMID:22579593^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(CHEBI:45951)	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:17179145^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0015020	glucuronosyltransferase activity	PMID:1898728^[3]	ECO:0005801	enzymatic activity assay evidence used in manual assertion		F		Seeded From UniProt	complete
NOT\|enables	GO:0001972	retinoic acid binding	PMID:20308471^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0052697	xenobiotic glucuronidation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000230517 RGD:3935 UniProtKB:O60656 UniProtKB:P22309 UniProtKB:P35503 UniProtKB:Q9HAW7 UniProtKB:Q9HAW9	P		Seeded From UniProt	complete
involved_in	GO:0052696	flavonoid glucuronidation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000230517 RGD:3935 UniProtKB:O60656 UniProtKB:P22309 UniProtKB:P35503 UniProtKB:Q9HAW7 UniProtKB:Q9HAW9	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000230403 RGD:3935 RGD:620895 RGD:620949 RGD:708541	C		Seeded From UniProt	complete
enables	GO:0008194	UDP-glycosyltransferase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2145969 MGI:MGI:2146055 PANTHER:PTN000230403 TAIR:locus:2028190 TAIR:locus:2040570 TAIR:locus:2093089 TAIR:locus:2093104 TAIR:locus:2142654 TAIR:locus:2198791 UniProtKB:Q3SY77 UniProtKB:Q6NUS8 UniProtKB:Q7XT97 UniProtKB:Q9M156	F		Seeded From UniProt	complete
enables	GO:0016758	transferase activity, transferring hexosyl groups	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002213	F		Seeded From UniProt	complete
enables	GO:0015020	glucuronosyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.4.1.17	F		Seeded From UniProt	complete
enables	GO:0015020	glucuronosyltransferase activity	PMID:20610558^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HAW7-1	F		Seeded From UniProt	complete
involved_in	GO:0052695	cellular glucuronidation	PMID:20610558^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HAW7-1	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:20610558^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9HAW9-2	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:20610558^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35503-3	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:20610558^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P22310-2	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:20610558^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P19224-3	F		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:20610558^[6]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:20610558^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9HAW8-2	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:20610558^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9HAW7-2	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:20610558^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P22309-2	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:20610558^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O60656-2	F		Seeded From UniProt	complete
NOT\|involved_in	GO:0017144	drug metabolic process	PMID:20610558^[6]	ECO:0000320	phylogenetic determination of loss of key residues evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904224	negative regulation of glucuronosyltransferase activity	PMID:20610558^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HAW9-2	P		Seeded From UniProt	complete
involved_in	GO:2001030	negative regulation of cellular glucuronidation	PMID:20610558^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HAW9-2	P		Seeded From UniProt	complete
involved_in	GO:0045922	negative regulation of fatty acid metabolic process	PMID:20610558^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HAW9-2	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:20610558^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9HAW9-1	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:20610558^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9HAW8-1	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:20610558^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9HAW7-1	F		Seeded From UniProt	complete
NOT\|enables	GO:0015020	glucuronosyltransferase activity	PMID:20610558^[6]	ECO:0000320	phylogenetic determination of loss of key residues evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:20610558^[6]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
NOT\|part_of	GO:0005789	endoplasmic reticulum membrane	PMID:20610558^[6]	ECO:0000320	phylogenetic determination of loss of key residues evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:20610558^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9HAW9-1	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:20610558^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9HAW8-1	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:20610558^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9HAW7-1	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:20610558^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35503-1	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:20610558^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P22310-1	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:20610558^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P22309-1	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:20610558^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P19224-1	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:20610558^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O60656-1	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:20610558^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35503-1	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:20610558^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P22310-1	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:20610558^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P22309-1	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:20610558^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P19224-1	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:20610558^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O60656-1	F		Seeded From UniProt	complete
involved_in	GO:0052695	cellular glucuronidation	Reactome:R-HSA-156588	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042167	heme catabolic process	Reactome:R-HSA-189483	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006789	bilirubin conjugation	Reactome:R-HSA-159194	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	Reactome:R-HSA-174916 Reactome:R-HSA-159194 Reactome:R-HSA-159179	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0492 UniProtKB-SubCell:SL-0166	C		Seeded From UniProt	complete
enables	GO:0016757	transferase activity, transferring glycosyl groups	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0328	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Gagez, AL et al. (2012) Simultaneous evaluation of six human glucuronidation activities in liver microsomes using liquid chromatography-tandem mass spectrometry. Anal. Biochem. 427 52-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Operaña, TN & Tukey, RH (2007) Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation. J. Biol. Chem. 282 4821-9 PubMed GONUTS page
↑ Ritter, JK et al. (1991) Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells. J. Biol. Chem. 266 1043-7 PubMed GONUTS page
↑ Rowbotham, SE et al. (2010) Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans. Drug Metab. Dispos. 38 1211-7 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 ^6.13 ^6.14 ^6.15 ^6.16 ^6.17 ^6.18 ^6.19 ^6.20 ^6.21 ^6.22 ^6.23 ^6.24 ^6.25 ^6.26 ^6.27 ^6.28 ^6.29 ^6.30 ^6.31 ^6.32 ^6.33 Bellemare, J et al. (2010) Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro. Drug Metab. Dispos. 38 1785-9 PubMed GONUTS page

[PMID:22579593-1] 1.0 ^1.1 Gagez, AL et al. (2012) Simultaneous evaluation of six human glucuronidation activities in liver microsomes using liquid chromatography-tandem mass spectrometry. Anal. Biochem. 427 52-9 PubMed GONUTS page

[PMID:17179145-2] 2.0 ^2.1 ^2.2 Operaña, TN & Tukey, RH (2007) Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation. J. Biol. Chem. 282 4821-9 PubMed GONUTS page

[PMID:1898728-3] Ritter, JK et al. (1991) Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells. J. Biol. Chem. 266 1043-7 PubMed GONUTS page

[PMID:20308471-4] Rowbotham, SE et al. (2010) Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans. Drug Metab. Dispos. 38 1211-7 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20610558-6] 6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 ^6.13 ^6.14 ^6.15 ^6.16 ^6.17 ^6.18 ^6.19 ^6.20 ^6.21 ^6.22 ^6.23 ^6.24 ^6.25 ^6.26 ^6.27 ^6.28 ^6.29 ^6.30 ^6.31 ^6.32 ^6.33 Bellemare, J et al. (2010) Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro. Drug Metab. Dispos. 38 1785-9 PubMed GONUTS page

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HUMAN:UD14

Contents

Annotations

Notes

References

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