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HUMAN:UBE2A

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) UBE2A (synonyms: RAD6A)
Protein Name(s) Ubiquitin-conjugating enzyme E2 A

RAD6 homolog A HR6A hHR6A Ubiquitin carrier protein A Ubiquitin-protein ligase A

External Links
UniProt P49459
EMBL M74524
AK297696
AK313092
DQ068065
AC004913
CH471161
CH471161
CH471161
BC010175
CCDS CCDS14580.1
CCDS14581.1
PIR A41222
RefSeq NP_001269090.1
NP_003327.2
NP_861427.1
UniGene Hs.379466
ProteinModelPortal P49459
SMR P49459
BioGrid 113167
DIP DIP-24260N
IntAct P49459
MINT MINT-267059
STRING 9606.ENSP00000360613
PhosphoSite P49459
DMDM 33518639
MaxQB P49459
PaxDb P49459
PRIDE P49459
DNASU 7319
Ensembl ENST00000346330
ENST00000371558
GeneID 7319
KEGG hsa:7319
UCSC uc004erl.3
uc004erm.3
CTD 7319
GeneCards GC0XP118708
HGNC HGNC:12472
MIM 300860
312180
neXtProt NX_P49459
Orphanet 163956
PharmGKB PA37122
eggNOG COG5078
GeneTree ENSGT00730000110565
HOGENOM HOG000233454
HOVERGEN HBG063308
InParanoid P49459
KO K10573
OMA SENNIMM
OrthoDB EOG7M0NTH
PhylomeDB P49459
TreeFam TF101128
Reactome REACT_75842
SignaLink P49459
UniPathway UPA00143
ChiTaRS UBE2A
GeneWiki UBE2A
GenomeRNAi 7319
NextBio 28614
PRO PR:P49459
Proteomes UP000005640
Bgee P49459
CleanEx HS_UBE2A
ExpressionAtlas P49459
Genevestigator P49459
GO GO:0000785
GO:0005829
GO:0033503
GO:0000790
GO:0001741
GO:0016881
GO:0005524
GO:0031625
GO:0004842
GO:0002474
GO:0006281
GO:0033522
GO:0001701
GO:0060135
GO:0008284
GO:0006301
GO:0051865
GO:0070979
GO:0070936
GO:0000209
GO:0009411
GO:0006511
Gene3D 3.10.110.10
InterPro IPR000608
IPR023313
IPR016135
Pfam PF00179
SUPFAM SSF54495
PROSITE PS00183
PS50127

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0070979

protein K11-linked ubiquitination

PMID:20061386[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070936

protein K48-linked ubiquitination

PMID:20061386[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051865

protein autoubiquitination

PMID:11953320[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0033522

histone H2A ubiquitination

PMID:11953320[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0033503

HULC complex

PMID:19410543[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

PMID:10908344[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9NS91

F

Seeded From UniProt

complete

involved_in

GO:0009411

response to UV

PMID:1717990[5]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P06104

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:11953320[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006511

ubiquitin-dependent protein catabolic process

PMID:1559696[6]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006301

postreplication repair

PMID:1559696[6]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

PMID:1717990[5]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P06104

P

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:20061386[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:11953320[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0000785

chromatin

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z255

C

Seeded From UniProt

complete

enables

GO:0061631

ubiquitin conjugating enzyme activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:102944
MGI:MGI:102959
PANTHER:PTN000630651
PomBase:SPAC18B11.07c
UniProtKB:P49459
WB:WBGene00006701

F

Seeded From UniProt

complete

involved_in

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004436
PANTHER:PTN000630651
PomBase:SPAC18B11.07c
UniProtKB:P63146

P

Seeded From UniProt

complete

part_of

GO:0033503

HULC complex

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000630652
PomBase:SPAC18B11.07c
UniProtKB:P49459
UniProtKB:P63146

C

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004436
PANTHER:PTN000630651
UniProtKB:P49459
UniProtKB:P63146
WB:WBGene00006701

P

Seeded From UniProt

complete

part_of

GO:0000790

nuclear chromatin

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:102944
MGI:MGI:102959
PANTHER:PTN000630652
SGD:S000003026

C

Seeded From UniProt

complete

involved_in

GO:0000209

protein polyubiquitination

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000630651
SGD:S000003026
UniProtKB:P63146

P

Seeded From UniProt

complete

enables

GO:0061631

ubiquitin conjugating enzyme activity

PMID:20061386[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0061631

ubiquitin conjugating enzyme activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z255
ensembl:ENSMUSP00000016452

F

Seeded From UniProt

complete

involved_in

GO:0060135

maternal process involved in female pregnancy

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z255
ensembl:ENSMUSP00000016452

P

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z255
ensembl:ENSMUSP00000016452

F

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z255
ensembl:ENSMUSP00000016452

P

Seeded From UniProt

complete

involved_in

GO:0001835

blastocyst hatching

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z255
ensembl:ENSMUSP00000016452

P

Seeded From UniProt

complete

part_of

GO:0001741

XY body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z255
ensembl:ENSMUSP00000016452

C

Seeded From UniProt

complete

involved_in

GO:0001701

in utero embryonic development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z255
ensembl:ENSMUSP00000016452

P

Seeded From UniProt

complete

part_of

GO:0000790

nuclear chromatin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z255
ensembl:ENSMUSP00000016452

C

Seeded From UniProt

complete

part_of

GO:0000785

chromatin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z255
ensembl:ENSMUSP00000016452

C

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

Reactome:R-HSA-8866654
Reactome:R-HSA-8866652

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-983157
Reactome:R-HSA-983156
Reactome:R-HSA-983152
Reactome:R-HSA-983140

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-8942101
Reactome:R-HSA-8942099
Reactome:R-HSA-8852130

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

involved_in

GO:0000209

protein polyubiquitination

Reactome:R-HSA-983168

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 David, Y et al. (2010) The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. J. Biol. Chem. 285 8595-604 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Sarcevic, B et al. (2002) Regulation of the ubiquitin-conjugating enzyme hHR6A by CDK-mediated phosphorylation. EMBO J. 21 2009-18 PubMed GONUTS page
  3. ↑ Kim, J et al. (2009) RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells. Cell 137 459-71 PubMed GONUTS page
  4. ↑ Xin, H et al. (2000) The human RAD18 gene product interacts with HHR6A and HHR6B. Nucleic Acids Res. 28 2847-54 PubMed GONUTS page
  5. ↑ 5.0 5.1 Koken, MH et al. (1991) Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6. Proc. Natl. Acad. Sci. U.S.A. 88 8865-9 PubMed GONUTS page
  6. ↑ 6.0 6.1 Koken, MH et al. (1992) Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31. Genomics 12 447-53 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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