HUMAN:UB2D4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	UBE2D4 (synonyms: UBCH5D)
Protein Name(s)	Ubiquitin-conjugating enzyme E2 D4 HBUCE1 Ubiquitin carrier protein D4 Ubiquitin-protein ligase D4
External Links
UniProt	Q9Y2X8
EMBL	AF125044 AK001446 CH236951 CH471073 BC004104
CCDS	CCDS5474.1
RefSeq	NP_057067.1
UniGene	Hs.19196
ProteinModelPortal	Q9Y2X8
SMR	Q9Y2X8
BioGrid	119641
IntAct	Q9Y2X8
MINT	MINT-1192345
STRING	9606.ENSP00000222402
PhosphoSite	Q9Y2X8
DMDM	74753478
MaxQB	Q9Y2X8
PaxDb	Q9Y2X8
PRIDE	Q9Y2X8
DNASU	51619
Ensembl	ENST00000222402
GeneID	51619
KEGG	hsa:51619
UCSC	uc003tja.2
CTD	51619
GeneCards	GC07P043966
HGNC	HGNC:21647
HPA	HPA003920
neXtProt	NX_Q9Y2X8
PharmGKB	PA134954568
eggNOG	COG5078
GeneTree	ENSGT00760000119012
HOGENOM	HOG000233455
HOVERGEN	HBG063308
InParanoid	Q9Y2X8
KO	K06689
OMA	MIAREWT
PhylomeDB	Q9Y2X8
TreeFam	TF101108
Reactome	REACT_75842
SignaLink	Q9Y2X8
UniPathway	UPA00143
GenomeRNAi	51619
NextBio	55531
PRO	PR:Q9Y2X8
Proteomes	UP000005640
Bgee	Q9Y2X8
CleanEx	HS_UBE2D4
ExpressionAtlas	Q9Y2X8
Genevestigator	Q9Y2X8
GO	GO:0016881 GO:0005524 GO:0004842 GO:0070979 GO:0044314 GO:0035519 GO:0070936 GO:0085020 GO:0070534
Gene3D	3.10.110.10
InterPro	IPR000608 IPR023313 IPR016135
Pfam	PF00179
SUPFAM	SSF54495
PROSITE	PS00183 PS50127

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0085020	protein K6-linked ubiquitination	PMID:20061386^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070979	protein K11-linked ubiquitination	PMID:20061386^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070936	protein K48-linked ubiquitination	PMID:20061386^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070534	protein K63-linked ubiquitination	PMID:20061386^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0044314	protein K27-linked ubiquitination	PMID:20061386^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035519	protein K29-linked ubiquitination	PMID:20061386^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:20061386^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0070979	protein K11-linked ubiquitination	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000631139 UniProtKB:Q9Y2X8	P	Seeded From UniProt	complete
involved_in	GO:0070936	protein K48-linked ubiquitination	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000631139 UniProtKB:Q9Y2X8	P	Seeded From UniProt	complete
involved_in	GO:0070534	protein K63-linked ubiquitination	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000631139 UniProtKB:Q9Y2X8	P	Seeded From UniProt	complete
enables	GO:0061631	ubiquitin conjugating enzyme activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000173 FB:FBgn0011217 FB:FBgn0026316 FB:FBgn0035601 FB:FBgn0264848 MGI:MGI:104632 MGI:MGI:107411 MGI:MGI:107412 MGI:MGI:109240 MGI:MGI:1913839 MGI:MGI:1914049 MGI:MGI:1917343 MGI:MGI:1917870 MGI:MGI:1934835 MGI:MGI:2384911 MGI:MGI:2388672 PANTHER:PTN002514495 PomBase:SPAC11E3.04c PomBase:SPBC119.02 PomBase:SPCC1259.15c PomBase:SPCC338.05c UniProtKB:A1L167 UniProtKB:O00762 UniProtKB:P51668 UniProtKB:P51965 UniProtKB:P61077 UniProtKB:P61085 UniProtKB:P62837 UniProtKB:P68036 UniProtKB:Q16763 UniProtKB:Q8N2K1 UniProtKB:Q96LR5 UniProtKB:Q9NPD8 UniProtKB:Q9Y2X8 UniProtKB:Q9Y385 WB:WBGene00006713	F	Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011217 FB:FBgn0026316 PANTHER:PTN000630862 UniProtKB:P68036 WB:WBGene00002344 WB:WBGene00006713	F	Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011217 MGI:MGI:109240 PANTHER:PTN000631055 PomBase:SPBC119.02 RGD:619912 UniProtKB:P51668	P	Seeded From UniProt	complete
part_of	GO:0000151	ubiquitin ligase complex	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000630862 UniProtKB:P51668 UniProtKB:P62837	C	Seeded From UniProt	complete
enables	GO:0061631	ubiquitin conjugating enzyme activity	PMID:21685362^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:21685362^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 David, Y et al. (2010) The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. J. Biol. Chem. 285 8595-604 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 Zhang, L et al. (2011) The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor. Genes Dev. 25 1262-74 PubMed GONUTS page

[PMID:20061386-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 David, Y et al. (2010) The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. J. Biol. Chem. 285 8595-604 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21685362-3] 3.0 ^3.1 Zhang, L et al. (2011) The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor. Genes Dev. 25 1262-74 PubMed GONUTS page

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HUMAN:UB2D4

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