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HUMAN:TYRP1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | TYRP1 (synonyms: CAS2, TYRP, TYRRP) | |
| Protein Name(s) | 5,6-dihydroxyindole-2-carboxylic acid oxidase
DHICA oxidase Catalase B Glycoprotein 75 Melanoma antigen gp75 Tyrosinase-related protein 1 TRP TRP-1 TRP1 | |
| External Links | ||
| UniProt | P17643 | |
| EMBL | X51420 AF001295 L38952 D83059 BC052608 X51455 X60955 | |
| CCDS | CCDS34990.1 | |
| PIR | S09999 | |
| RefSeq | NP_000541.1 | |
| UniGene | Hs.270279 | |
| ProteinModelPortal | P17643 | |
| SMR | P17643 | |
| BioGrid | 113156 | |
| IntAct | P17643 | |
| MINT | MINT-1784675 | |
| STRING | 9606.ENSP00000373570 | |
| PhosphoSite | P17643 | |
| DMDM | 12644141 | |
| PaxDb | P17643 | |
| PRIDE | P17643 | |
| Ensembl | ENST00000388918 | |
| GeneID | 7306 | |
| KEGG | hsa:7306 | |
| UCSC | uc003zkv.4 | |
| CTD | 7306 | |
| GeneCards | GC09P012683 | |
| HGNC | HGNC:12450 | |
| HPA | CAB002520 HPA000937 | |
| MIM | 115501 203290 612271 | |
| neXtProt | NX_P17643 | |
| Orphanet | 79433 | |
| PharmGKB | PA37101 | |
| eggNOG | NOG86242 | |
| GeneTree | ENSGT00500000044790 | |
| HOGENOM | HOG000118376 | |
| HOVERGEN | HBG003553 | |
| InParanoid | P17643 | |
| KO | K00506 | |
| OMA | YYSVKKT | |
| PhylomeDB | P17643 | |
| TreeFam | TF315865 | |
| UniPathway | UPA00785 | |
| GeneWiki | TYRP1 | |
| GenomeRNAi | 7306 | |
| NextBio | 28568 | |
| PRO | PR:P17643 | |
| Proteomes | UP000005640 | |
| Bgee | P17643 | |
| CleanEx | HS_TYRP1 | |
| ExpressionAtlas | P17643 | |
| Genevestigator | P17643 | |
| GO | GO:0030669 GO:0010008 GO:0016021 GO:0042470 GO:0033162 GO:0005507 GO:0016716 GO:0046982 GO:0042803 GO:0043438 GO:0042438 GO:0030318 GO:0032438 | |
| Gene3D | 1.10.1280.10 | |
| InterPro | IPR015559 IPR002227 IPR008922 | |
| PANTHER | PTHR11474:SF3 | |
| Pfam | PF00264 | |
| PRINTS | PR00092 | |
| SUPFAM | SSF48056 | |
| PROSITE | PS00497 PS00498 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0048023 |
positive regulation of melanin biosynthetic process |
ECO:0000315 |
P |
Based on results in Fig. 2C |
complete | |||||
|
enables |
GO:0004503 |
monophenol monooxygenase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0097708 |
intracellular vesicle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048023 |
positive regulation of melanin biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042470 |
melanosome |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0033162 |
melanosome membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030669 |
clathrin-coated endocytic vesicle membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0010008 |
endosome membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043473 |
pigmentation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98881 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0042470 |
melanosome |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98881 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032438 |
melanosome organization |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98881 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030318 |
melanocyte differentiation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98881 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048023 |
positive regulation of melanin biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07147 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07147 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043473 |
pigmentation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07147 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043438 |
acetoacetic acid metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07147 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07147 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0042470 |
melanosome |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07147 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0033162 |
melanosome membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07147 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032438 |
melanosome organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07147 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030318 |
melanocyte differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07147 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006582 |
melanin metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07147 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042438 |
melanin biosynthetic process |
Reactome:R-HSA-5662702 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0033162 |
melanosome membrane |
Reactome:R-HSA-8878581 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016491 |
oxidoreductase activity |
Reactome:R-HSA-8878581 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004497 |
monooxygenase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042438 |
melanin biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0470 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042470 |
melanosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0033162 |
melanosome membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Yamada, M et al. (2011) Oculocutaneous albinism type 3: a Japanese girl with novel mutations in TYRP1 gene. J. Dermatol. Sci. 64 217-22 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Kedlaya, R et al. (2011) Interactions between GIPC-APPL and GIPC-TRP1 regulate melanosomal protein trafficking and melanogenesis in human melanocytes. Arch. Biochem. Biophys. 508 227-33 PubMed GONUTS page
- ↑ 3.0 3.1 Delevoye, C et al. (2009) AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesis. J. Cell Biol. 187 247-64 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
c
m
- Mammalia
- GO:0042438 ! melanin biosynthetic process
- GO:0006582 ! melanin metabolic process
- GO:0030318 ! melanocyte differentiation
- GO:0042470 ! melanosome
- GO:0033162 ! melanosome membrane
- GO:0032438 ! melanosome organization
- GO:0016020 ! membrane
- GO:0046872 ! metal ion binding
- Metazoa
- GO:0004497 ! monooxygenase activity
p
