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HUMAN:TRXR2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TXNRD2 (synonyms: KIAA1652, TRXR2)
Protein Name(s) Thioredoxin reductase 2, mitochondrial

Selenoprotein Z SelZ TR-beta Thioredoxin reductase TR3

External Links
UniProt Q9NNW7
EMBL AF171054
AF106697
AF044212
AB019694
AB019695
AF166126
AF166127
AF201385
AC000078
AC000080
AC000090
BC007489
CCDS CCDS42981.1
RefSeq NP_001269441.1
NP_006431.2
UniGene Hs.443430
PDB 1W1E
PDBsum 1W1E
ProteinModelPortal Q9NNW7
SMR Q9NNW7
BioGrid 115836
ChEMBL CHEMBL2096978
PhosphoSite Q9NNW7
DMDM 182705230
MaxQB Q9NNW7
PaxDb Q9NNW7
PRIDE Q9NNW7
DNASU 10587
GeneID 10587
KEGG hsa:10587
UCSC uc002zqq.1
uc021wlj.1
CTD 10587
GeneCards GC22M019863
H-InvDB HIX0016244
HGNC HGNC:18155
HPA CAB002007
HPA003323
MIM 606448
neXtProt NX_Q9NNW7
Orphanet 154
PharmGKB PA38302
eggNOG COG1249
GeneTree ENSGT00390000007578
HOVERGEN HBG004959
InParanoid Q9NNW7
KO K00384
OMA VMRTVGI
PhylomeDB Q9NNW7
TreeFam TF314782
Reactome REACT_172715
ChiTaRS TXNRD2
GenomeRNAi 10587
NextBio 40203
PRO PR:Q9NNW7
Proteomes UP000005640
Bgee Q9NNW7
ExpressionAtlas Q9NNW7
Genevestigator Q9NNW7
GO GO:0005759
GO:0005739
GO:0050660
GO:0050661
GO:0004791
GO:0045454
GO:0007507
GO:0030097
GO:0000305
Gene3D 3.30.390.30
InterPro IPR016156
IPR013027
IPR004099
IPR023753
IPR012999
IPR001327
IPR006338
Pfam PF00070
PF07992
PF02852
PRINTS PR00368
SUPFAM SSF55424
TIGRFAMs TIGR01438
PROSITE PS00076

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0045454

cell redox homeostasis

PMID:24601690[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:10215850[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004791

thioredoxin-disulfide reductase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z0J5

F

Seeded From UniProt

complete

involved_in

GO:0045454

cell redox homeostasis

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0020653
PANTHER:PTN000530450

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0020653
MGI:MGI:1347023
PANTHER:PTN002456835
RGD:61960
UniProtKB:Q9N2I8
UniProtKB:Q9NNW7
WB:WBGene00014028

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0020653
MGI:MGI:1354175
PANTHER:PTN000530450
RGD:61959
RGD:61960
UniProtKB:A0A143ZVU1
UniProtKB:O15770
UniProtKB:P61076

C

Seeded From UniProt

complete

enables

GO:0004791

thioredoxin-disulfide reductase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0020653
FB:FBgn0037170
MGI:MGI:1354175
MGI:MGI:2386711
PANTHER:PTN001487220
RGD:61959
RGD:61960
UniProtKB:Q16881
UniProtKB:Q9N2I8
UniProtKB:Q9NNW7
WB:WBGene00014028

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0022900

electron transport chain

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0009055

P

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004791

P

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004791

P

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004791

P

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004791

P

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004791

P

Seeded From UniProt

complete

enables

GO:0004791

thioredoxin-disulfide reductase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006338

F

Seeded From UniProt

complete

enables

GO:0009055

electron transfer activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001100

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001100
InterPro:IPR016156
InterPro:IPR023753

F

Seeded From UniProt

complete

enables

GO:0016668

oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012999

F

Seeded From UniProt

complete

involved_in

GO:0045454

cell redox homeostasis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004099

P

Seeded From UniProt

complete

enables

GO:0050660

flavin adenine dinucleotide binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016156

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004099
InterPro:IPR012999
InterPro:IPR016156
InterPro:IPR023753

P

Seeded From UniProt

complete

enables

GO:0004791

thioredoxin-disulfide reductase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.8.1.9

F

Seeded From UniProt

complete

enables

GO:0004791

thioredoxin-disulfide reductase activity

PMID:9923614[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000305

response to oxygen radical

PMID:10455115[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034599

cellular response to oxidative stress

Reactome:R-HSA-3299685

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

Reactome:R-HSA-3323050

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496
UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Prasad, R et al. (2014) Thioredoxin Reductase 2 (TXNRD2) mutation associated with familial glucocorticoid deficiency (FGD). J. Clin. Endocrinol. Metab. 99 E1556-63 PubMed GONUTS page
  2. ↑ Miranda-Vizuete, A et al. (1999) Human mitochondrial thioredoxin reductase cDNA cloning, expression and genomic organization. Eur. J. Biochem. 261 405-12 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ Gasdaska, PY et al. (1999) Cloning, sequencing and functional expression of a novel human thioredoxin reductase. FEBS Lett. 442 105-11 PubMed GONUTS page
  5. ↑ Sun, QA et al. (1999) Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases. J. Biol. Chem. 274 24522-30 PubMed GONUTS page
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