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HUMAN:TRAP1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TRAP1 (synonyms: HSP75)
Protein Name(s) Heat shock protein 75 kDa, mitochondrial

HSP 75 TNFR-associated protein 1 Tumor necrosis factor type 1 receptor-associated protein TRAP-1

External Links
UniProt Q12931
EMBL AF154108
AK299127
AC005203
AC006111
CH471112
CH471112
BC018950
BC023585
U12595
AF043254
CCDS CCDS10508.1
CCDS61824.1
RefSeq NP_001258978.1
NP_057376.2
UniGene Hs.30345
ProteinModelPortal Q12931
SMR Q12931
BioGrid 115435
DIP DIP-6250N
IntAct Q12931
MINT MINT-1510364
STRING 9606.ENSP00000246957
BindingDB Q12931
ChEMBL CHEMBL1075132
PhosphoSite Q12931
DMDM 67477458
REPRODUCTION-2DPAGE IPI00030275
MaxQB Q12931
PaxDb Q12931
PeptideAtlas Q12931
PRIDE Q12931
Ensembl ENST00000246957
ENST00000538171
GeneID 10131
KEGG hsa:10131
UCSC uc002cvs.3
CTD 10131
GeneCards GC16M003710
H-InvDB HIX0012776
HGNC HGNC:16264
HPA HPA041082
HPA044227
MIM 606219
neXtProt NX_Q12931
PharmGKB PA36781
eggNOG COG0326
GeneTree ENSGT00760000119253
HOGENOM HOG000031987
HOVERGEN HBG103147
InParanoid Q12931
KO K09488
OMA AHDKPRY
OrthoDB EOG7C8GGM
PhylomeDB Q12931
TreeFam TF315234
ChiTaRS TRAP1
GeneWiki TRAP1
GenomeRNAi 10131
NextBio 35474312
PRO PR:Q12931
Proteomes UP000005640
Bgee Q12931
CleanEx HS_TRAP1
ExpressionAtlas Q12931
Genevestigator Q12931
GO GO:0070062
GO:0005811
GO:0016020
GO:0005743
GO:0005758
GO:0005759
GO:0005739
GO:0005634
GO:0005524
GO:0044822
GO:0019901
GO:0005164
GO:0061077
GO:1901856
GO:1902176
GO:1903427
GO:0006950
Gene3D 3.30.565.10
HAMAP MF_00505
InterPro IPR003594
IPR001404
IPR020575
IPR020568
PANTHER PTHR11528
Pfam PF02518
PF00183
PIRSF PIRSF002583
PRINTS PR00775
SMART SM00387
SUPFAM SSF54211
SSF55874

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0009386

translational attenuation

PMID:24113185[1]

ECO:0000315

P

Figure 1a: Control cells incorporate less radioactively labeled amino acids compared with TRAP1 KD cells (total lysates brief exposure), suggesting a role for TRAP1 in the global attenuation of translation.

complete
CACAO 8865

involved_in

GO:0009386

translational attenuation

PMID:24113185[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005758

mitochondrial intermembrane space

PMID:17579517[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5XHZ0

C

Seeded From UniProt

complete

involved_in

GO:1903751

negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide

PMID:17579517[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5XHZ0

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:19946888[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:17579517[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:17579517[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9BXM7

F

Seeded From UniProt

complete

involved_in

GO:1901856

negative regulation of cellular respiration

PMID:23564345[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

PMID:23564345[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

PMID:23564345[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005164

tumor necrosis factor receptor binding

PMID:7876093[6]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0051082

unfolded protein binding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0001233
PANTHER:PTN000163527
PomBase:SPAC926.04c
SGD:S000004798
SGD:S000006161

F

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000163576
RGD:1359733
UniProtKB:Q12931

F

Seeded From UniProt

complete

involved_in

GO:0006457

protein folding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000201062
EcoGene:EG10461
PANTHER:PTN000163527
PomBase:SPAC926.04c
SGD:S000004798
SGD:S000006161
WB:WBGene00000915

P

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000163576
RGD:1359733
UniProtKB:Q12931

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0026761
PANTHER:PTN000163576
RGD:1359733
UniProtKB:Q12931

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1903751

negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5XHZ0
ensembl:ENSRNOP00000008966

P

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5XHZ0
ensembl:ENSRNOP00000008966

F

Seeded From UniProt

complete

part_of

GO:0005758

mitochondrial intermembrane space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5XHZ0
ensembl:ENSRNOP00000008966

C

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5XHZ0
ensembl:ENSRNOP00000008966

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001404

F

Seeded From UniProt

complete

involved_in

GO:0006457

protein folding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001404

P

Seeded From UniProt

complete

enables

GO:0051082

unfolded protein binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001404

F

Seeded From UniProt

complete

involved_in

GO:1903427

negative regulation of reactive oxygen species biosynthetic process

PMID:18221368[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061077

chaperone-mediated protein folding

PMID:24522549[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

part_of:(GO:0034599)

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496
UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0999
UniProtKB-SubCell:SL-0168

C

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0170

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Matassa, DS et al. (2013) Translational control in the stress adaptive response of cancer cells: a novel role for the heat shock protein TRAP1. Cell Death Dis 4 e851 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Pridgeon, JW et al. (2007) PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1. PLoS Biol. 5 e172 PubMed GONUTS page
  3. ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Yoshida, S et al. (2013) Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis. Proc. Natl. Acad. Sci. U.S.A. 110 E1604-12 PubMed GONUTS page
  5. ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  6. ↑ Song, HY et al. (1995) Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor. J. Biol. Chem. 270 3574-81 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 7.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  8. ↑ Mills, RD et al. (2008) Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1). J. Neurochem. 105 18-33 PubMed GONUTS page
  9. ↑ Gaki, GS & Papavassiliou, AG (2014) Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease. Neuromolecular Med. 16 217-30 PubMed GONUTS page
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