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HUMAN:TPH2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TPH2 (synonyms: NTPH)
Protein Name(s) Tryptophan 5-hydroxylase 2

Neuronal tryptophan hydroxylase Tryptophan 5-monooxygenase 2

External Links
UniProt Q8IWU9
EMBL AY098914
AC090109
BC114499
CCDS CCDS31859.1
RefSeq NP_775489.2
UniGene Hs.736576
PDB 4V06
PDBsum 4V06
ProteinModelPortal Q8IWU9
SMR Q8IWU9
BioGrid 125720
IntAct Q8IWU9
MINT MINT-7997360
STRING 9606.ENSP00000329093
BindingDB Q8IWU9
ChEMBL CHEMBL5433
DrugBank DB00150
GuidetoPHARMACOLOGY 1242
PhosphoSite Q8IWU9
DMDM 30580625
PaxDb Q8IWU9
PRIDE Q8IWU9
Ensembl ENST00000333850
GeneID 121278
KEGG hsa:121278
UCSC uc001swy.2
CTD 121278
GeneCards GC12P072332
HGNC HGNC:20692
HPA HPA046274
MIM 607478
608516
613003
neXtProt NX_Q8IWU9
PharmGKB PA128747823
eggNOG COG3186
GeneTree ENSGT00390000010268
HOGENOM HOG000233373
HOVERGEN HBG006841
InParanoid Q8IWU9
KO K00502
OMA HACKQFL
OrthoDB EOG7KM5T1
PhylomeDB Q8IWU9
TreeFam TF313327
BioCyc MetaCyc:HS06603-MONOMER
Reactome REACT_15439
SABIO-RK Q8IWU9
UniPathway UPA00846
GeneWiki TPH2
GenomeRNAi 121278
NextBio 80710
PRO PR:Q8IWU9
Proteomes UP000005640
Bgee Q8IWU9
CleanEx HS_TPH2
ExpressionAtlas Q8IWU9
Genevestigator Q8IWU9
GO GO:0005829
GO:0043005
GO:0016597
GO:0005506
GO:0004510
GO:0009072
GO:0034641
GO:0071285
GO:0007623
GO:0046219
GO:0014823
GO:0051592
GO:0043627
GO:0051384
GO:0031667
GO:0042427
GO:0044281
Gene3D 1.10.800.10
InterPro IPR002912
IPR001273
IPR018301
IPR019774
IPR005963
IPR019773
PANTHER PTHR11473
Pfam PF01842
PF00351
PIRSF PIRSF000336
PRINTS PR00372
SUPFAM SSF56534
TIGRFAMs TIGR01270
PROSITE PS51671
PS00367
PS51410

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0043005

neuron projection

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2651811
PANTHER:PTN000158467
RGD:3895
WB:WBGene00006600

C

Seeded From UniProt

complete

enables

GO:0004510

tryptophan 5-monooxygenase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0035187
MGI:MGI:2651811
MGI:MGI:98796
PANTHER:PTN000158467
RGD:3895

F

Seeded From UniProt

complete

involved_in

GO:0071285

cellular response to lithium ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CGU9
ensembl:ENSRNOP00000005157

P

Seeded From UniProt

complete

involved_in

GO:0051592

response to calcium ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CGU9
ensembl:ENSRNOP00000005157

P

Seeded From UniProt

complete

involved_in

GO:0051384

response to glucocorticoid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CGU9
ensembl:ENSRNOP00000005157

P

Seeded From UniProt

complete

involved_in

GO:0043627

response to estrogen

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CGU9
ensembl:ENSRNOP00000005157

P

Seeded From UniProt

complete

involved_in

GO:0031667

response to nutrient levels

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CGU9
ensembl:ENSRNOP00000005157

P

Seeded From UniProt

complete

involved_in

GO:0014823

response to activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CGU9
ensembl:ENSRNOP00000005157

P

Seeded From UniProt

complete

involved_in

GO:0007623

circadian rhythm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CGU9
ensembl:ENSRNOP00000005157

P

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CGV2
ensembl:ENSMUSP00000006949

C

Seeded From UniProt

complete

enables

GO:0004510

tryptophan 5-monooxygenase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8CGV2
ensembl:ENSMUSP00000006949

F

Seeded From UniProt

complete

enables

GO:0004497

monooxygenase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001273
InterPro:IPR018301
InterPro:IPR036951

F

Seeded From UniProt

complete

enables

GO:0004510

tryptophan 5-monooxygenase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005963

F

Seeded From UniProt

complete

enables

GO:0005506

iron ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001273
InterPro:IPR018301
InterPro:IPR036951

F

Seeded From UniProt

complete

involved_in

GO:0009072

aromatic amino acid family metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001273
InterPro:IPR018301
InterPro:IPR036951

P

Seeded From UniProt

complete

enables

GO:0016714

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR019773
InterPro:IPR019774

F

Seeded From UniProt

complete

involved_in

GO:0042427

serotonin biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005963

P

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001273
InterPro:IPR005963
InterPro:IPR018301
InterPro:IPR019773
InterPro:IPR019774
InterPro:IPR036951

P

Seeded From UniProt

complete

enables

GO:0004510

tryptophan 5-monooxygenase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.14.16.4

F

Seeded From UniProt

complete

involved_in

GO:0046219

indolalkylamine biosynthetic process

Reactome:R-HSA-209931

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-209828

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004497

monooxygenase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0503

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0042427

serotonin biosynthetic process

GO_REF:0000037
GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0724
UniPathway:UPA00846

P

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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