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HUMAN:TPH1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | TPH1 (synonyms: TPH, TPRH, TRPH) | |
| Protein Name(s) | Tryptophan 5-hydroxylase 1
Tryptophan 5-monooxygenase 1 | |
| External Links | ||
| UniProt | P17752 | |
| EMBL | X52836 L29306 CH471064 CH471064 BC106739 AF057280 AF057280 | |
| CCDS | CCDS7829.1 | |
| PIR | S10489 | |
| RefSeq | NP_004170.1 | |
| UniGene | Hs.591999 | |
| PDB | 1IN9 1MLW 3HF6 3HF8 3HFB | |
| PDBsum | 1IN9 1MLW 3HF6 3HF8 3HFB | |
| ProteinModelPortal | P17752 | |
| SMR | P17752 | |
| BioGrid | 113019 | |
| IntAct | P17752 | |
| STRING | 9606.ENSP00000250018 | |
| BindingDB | P17752 | |
| ChEMBL | CHEMBL5689 | |
| DrugBank | DB00150 DB00360 | |
| GuidetoPHARMACOLOGY | 1241 | |
| PhosphoSite | P17752 | |
| DMDM | 116242823 | |
| PaxDb | P17752 | |
| PRIDE | P17752 | |
| Ensembl | ENST00000250018 | |
| GeneID | 7166 | |
| KEGG | hsa:7166 | |
| UCSC | uc001mnp.2 | |
| CTD | 7166 | |
| GeneCards | GC11M018040 | |
| HGNC | HGNC:12008 | |
| HPA | CAB010767 HPA022483 | |
| MIM | 191060 | |
| neXtProt | NX_P17752 | |
| PharmGKB | PA355 | |
| eggNOG | COG3186 | |
| GeneTree | ENSGT00390000010268 | |
| HOGENOM | HOG000233373 | |
| HOVERGEN | HBG006841 | |
| InParanoid | P17752 | |
| KO | K00502 | |
| OMA | QNVLMYG | |
| OrthoDB | EOG7KM5T1 | |
| PhylomeDB | P17752 | |
| TreeFam | TF313327 | |
| BioCyc | MetaCyc:HS05250-MONOMER | |
| Reactome | REACT_15439 | |
| SABIO-RK | P17752 | |
| UniPathway | UPA00846 | |
| EvolutionaryTrace | P17752 | |
| GeneWiki | TPH1 | |
| GenomeRNAi | 7166 | |
| NextBio | 28062 | |
| PRO | PR:P17752 | |
| Proteomes | UP000005640 | |
| Bgee | P17752 | |
| CleanEx | HS_TPH1 | |
| ExpressionAtlas | P17752 | |
| Genevestigator | P17752 | |
| GO | GO:0005829 GO:0043005 GO:0016597 GO:0005506 GO:0004510 GO:0009072 GO:0046849 GO:0034641 GO:0007623 GO:0046219 GO:0060749 GO:0030279 GO:0035902 GO:0042427 GO:0044281 | |
| Gene3D | 1.10.800.10 | |
| InterPro | IPR002912 IPR001273 IPR018301 IPR019774 IPR005963 IPR019773 | |
| PANTHER | PTHR11473 | |
| Pfam | PF01842 PF00351 | |
| PIRSF | PIRSF000336 | |
| PRINTS | PR00372 | |
| SUPFAM | SSF56534 | |
| TIGRFAMs | TIGR01270 | |
| PROSITE | PS51671 PS00367 PS51410 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0043005 |
neuron projection |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2651811 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004510 |
tryptophan 5-monooxygenase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0035187 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043005 |
neuron projection |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P09810 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035902 |
response to immobilization stress |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P09810 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030279 |
negative regulation of ossification |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P09810 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007623 |
circadian rhythm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P09810 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004510 |
tryptophan 5-monooxygenase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P09810 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060749 |
mammary gland alveolus development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P17532 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046849 |
bone remodeling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P17532 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045600 |
positive regulation of fat cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P17532 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P17532 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004510 |
tryptophan 5-monooxygenase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P17532 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004497 |
monooxygenase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004510 |
tryptophan 5-monooxygenase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005506 |
iron ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009072 |
aromatic amino acid family metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016714 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042427 |
serotonin biosynthetic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001273 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004510 |
tryptophan 5-monooxygenase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046219 |
indolalkylamine biosynthetic process |
Reactome:R-HSA-209931 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-209828 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042427 |
serotonin biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0724 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004497 |
monooxygenase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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