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HUMAN:TPH1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TPH1 (synonyms: TPH, TPRH, TRPH)
Protein Name(s) Tryptophan 5-hydroxylase 1

Tryptophan 5-monooxygenase 1

External Links
UniProt P17752
EMBL X52836
L29306
CH471064
CH471064
BC106739
AF057280
AF057280
CCDS CCDS7829.1
PIR S10489
RefSeq NP_004170.1
UniGene Hs.591999
PDB 1IN9
1MLW
3HF6
3HF8
3HFB
PDBsum 1IN9
1MLW
3HF6
3HF8
3HFB
ProteinModelPortal P17752
SMR P17752
BioGrid 113019
IntAct P17752
STRING 9606.ENSP00000250018
BindingDB P17752
ChEMBL CHEMBL5689
DrugBank DB00150
DB00360
GuidetoPHARMACOLOGY 1241
PhosphoSite P17752
DMDM 116242823
PaxDb P17752
PRIDE P17752
Ensembl ENST00000250018
GeneID 7166
KEGG hsa:7166
UCSC uc001mnp.2
CTD 7166
GeneCards GC11M018040
HGNC HGNC:12008
HPA CAB010767
HPA022483
MIM 191060
neXtProt NX_P17752
PharmGKB PA355
eggNOG COG3186
GeneTree ENSGT00390000010268
HOGENOM HOG000233373
HOVERGEN HBG006841
InParanoid P17752
KO K00502
OMA QNVLMYG
OrthoDB EOG7KM5T1
PhylomeDB P17752
TreeFam TF313327
BioCyc MetaCyc:HS05250-MONOMER
Reactome REACT_15439
SABIO-RK P17752
UniPathway UPA00846
EvolutionaryTrace P17752
GeneWiki TPH1
GenomeRNAi 7166
NextBio 28062
PRO PR:P17752
Proteomes UP000005640
Bgee P17752
CleanEx HS_TPH1
ExpressionAtlas P17752
Genevestigator P17752
GO GO:0005829
GO:0043005
GO:0016597
GO:0005506
GO:0004510
GO:0009072
GO:0046849
GO:0034641
GO:0007623
GO:0046219
GO:0060749
GO:0030279
GO:0035902
GO:0042427
GO:0044281
Gene3D 1.10.800.10
InterPro IPR002912
IPR001273
IPR018301
IPR019774
IPR005963
IPR019773
PANTHER PTHR11473
Pfam PF01842
PF00351
PIRSF PIRSF000336
PRINTS PR00372
SUPFAM SSF56534
TIGRFAMs TIGR01270
PROSITE PS51671
PS00367
PS51410

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0043005

neuron projection

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2651811
PANTHER:PTN000158467
RGD:3895
WB:WBGene00006600

C

Seeded From UniProt

complete

enables

GO:0004510

tryptophan 5-monooxygenase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0035187
MGI:MGI:2651811
MGI:MGI:98796
PANTHER:PTN000158467
RGD:3895

F

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09810
ensembl:ENSRNOP00000052959

C

Seeded From UniProt

complete

involved_in

GO:0035902

response to immobilization stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09810
ensembl:ENSRNOP00000052959

P

Seeded From UniProt

complete

involved_in

GO:0030279

negative regulation of ossification

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09810
ensembl:ENSRNOP00000052959

P

Seeded From UniProt

complete

involved_in

GO:0007623

circadian rhythm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09810
ensembl:ENSRNOP00000052959

P

Seeded From UniProt

complete

enables

GO:0004510

tryptophan 5-monooxygenase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09810
ensembl:ENSRNOP00000052959

F

Seeded From UniProt

complete

involved_in

GO:0060749

mammary gland alveolus development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17532
ensembl:ENSMUSP00000037752

P

Seeded From UniProt

complete

involved_in

GO:0046849

bone remodeling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17532
ensembl:ENSMUSP00000037752

P

Seeded From UniProt

complete

involved_in

GO:0045600

positive regulation of fat cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17532
ensembl:ENSMUSP00000037752

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17532
ensembl:ENSMUSP00000037752

C

Seeded From UniProt

complete

enables

GO:0004510

tryptophan 5-monooxygenase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17532
ensembl:ENSMUSP00000037752

F

Seeded From UniProt

complete

enables

GO:0004497

monooxygenase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001273
InterPro:IPR018301
InterPro:IPR036951

F

Seeded From UniProt

complete

enables

GO:0004510

tryptophan 5-monooxygenase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005963

F

Seeded From UniProt

complete

enables

GO:0005506

iron ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001273
InterPro:IPR018301
InterPro:IPR036951

F

Seeded From UniProt

complete

involved_in

GO:0009072

aromatic amino acid family metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001273
InterPro:IPR018301
InterPro:IPR036951

P

Seeded From UniProt

complete

enables

GO:0016714

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR019773
InterPro:IPR019774

F

Seeded From UniProt

complete

involved_in

GO:0042427

serotonin biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005963

P

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001273
InterPro:IPR005963
InterPro:IPR018301
InterPro:IPR019773
InterPro:IPR019774
InterPro:IPR036951

P

Seeded From UniProt

complete

enables

GO:0004510

tryptophan 5-monooxygenase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.14.16.4

F

Seeded From UniProt

complete

involved_in

GO:0046219

indolalkylamine biosynthetic process

Reactome:R-HSA-209931

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-209828

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0042427

serotonin biosynthetic process

GO_REF:0000037
GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0724
UniPathway:UPA00846

P

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

enables

GO:0004497

monooxygenase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0503

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page