HUMAN:TNNI3

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TNNI3 (synonyms: TNNC1)
Protein Name(s)	Troponin I, cardiac muscle Cardiac troponin I
External Links
UniProt	P19429
EMBL	X54163 M64247 X90780
CCDS	CCDS42628.1
PIR	A61229
RefSeq	NP_000354.4
UniGene	Hs.709179
PDB	1J1D 1J1E 1LXF 1MXL 1OZS 2KGB 2KRD 2L1R
PDBsum	1J1D 1J1E 1LXF 1MXL 1OZS 2KGB 2KRD 2L1R
DisProt	DP00166
ProteinModelPortal	P19429
SMR	P19429
BioGrid	112991
DIP	DIP-34065N
IntAct	P19429
MINT	MINT-2801556
STRING	9606.ENSP00000341838
ChEMBL	CHEMBL2095202
PhosphoSite	P19429
DMDM	136213
PaxDb	P19429
PRIDE	P19429
DNASU	7137
Ensembl	ENST00000344887
GeneID	7137
KEGG	hsa:7137
UCSC	uc002qjg.4
CTD	7137
GeneCards	GC19M055663
GeneReviews	TNNI3
HGNC	HGNC:11947
HPA	HPA046428
MIM	115210 191044 611880 613286 613690
neXtProt	NX_P19429
Orphanet	154 155 75249
PharmGKB	PA36636
eggNOG	NOG270363
HOGENOM	HOG000293300
HOVERGEN	HBG052737
InParanoid	P19429
KO	K12044
OMA	RMYTCEG
OrthoDB	EOG71G9WD
PhylomeDB	P19429
TreeFam	TF313374
Reactome	REACT_16969
ChiTaRS	TNNI3
EvolutionaryTrace	P19429
GeneWiki	TNNI3
GenomeRNAi	7137
NextBio	27925
PRO	PR:P19429
Proteomes	UP000005640
Bgee	P19429
CleanEx	HS_TNNC1 HS_TNNI3
ExpressionAtlas	P19429
Genevestigator	P19429
GO	GO:0005829 GO:0030017 GO:0005861 GO:0003779 GO:0019855 GO:0048306 GO:0046872 GO:0019904 GO:0019901 GO:0030172 GO:0031014 GO:0060048 GO:0006874 GO:0060047 GO:0007507 GO:0030049 GO:0032780 GO:0006940 GO:0001980 GO:0001570 GO:0055010
InterPro	IPR001978 IPR021666
Pfam	PF00992 PF11636

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0051015	actin filament binding	PMID:25771144^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P68135	F	Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	PMID:25771144^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P58772,UniProtKB:P68135	F	Seeded From UniProt	complete
involved_in	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	PMID:25771144^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0097512	cardiac myofibril	PMID:25771144^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:1990584	cardiac Troponin complex	PMID:25771144^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0055010	ventricular cardiac muscle tissue morphogenesis	PMID:16754800^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0055010	ventricular cardiac muscle tissue morphogenesis	PMID:11815426^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060048	cardiac muscle contraction	PMID:11735257^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060047	heart contraction	PMID:12531876^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	PMID:7957210^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P63316	F	Seeded From UniProt	complete
involved_in	GO:0032780	negative regulation of ATPase activity	PMID:10806205^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032780	negative regulation of ATPase activity	PMID:11735257^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032780	negative regulation of ATPase activity	PMID:7957210^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0031014	troponin T binding	PMID:15542288^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P45379	F	Seeded From UniProt	complete
enables	GO:0030172	troponin C binding	PMID:11735257^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P63316	F	Seeded From UniProt	complete
enables	GO:0030172	troponin C binding	PMID:7957210^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P63316	F	Seeded From UniProt	complete
enables	GO:0030172	troponin C binding	PMID:15542288^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P63316	F	Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:11984006^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99698	F	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:12721663^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q59H18	F	Seeded From UniProt	complete
enables	GO:0019855	calcium channel inhibitor activity	PMID:12809519^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13563	F	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48787	P	Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48787	P	Seeded From UniProt	complete
part_of	GO:0005861	troponin complex	PMID:10806205^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005861	troponin complex	PMID:7957210^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005861	troponin complex	PMID:12093807^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005861	troponin complex	PMID:10850966^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003779	actin binding	PMID:10806205^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0001980	regulation of systemic arterial blood pressure by ischemic conditions	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48787	P	Seeded From UniProt	complete
involved_in	GO:0001570	vasculogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48787	P	Seeded From UniProt	complete
involved_in	GO:0060048	cardiac muscle contraction	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001011175 RGD:62052 UniProtKB:P19429	P	Seeded From UniProt	complete
involved_in	GO:0006936	muscle contraction	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000348305 WB:WBGene00006585	P	Seeded From UniProt	complete
part_of	GO:0005861	troponin complex	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000348305 RGD:62050 RGD:621765 UniProtKB:P19429 UniProtKB:P48788	C	Seeded From UniProt	complete
involved_in	GO:0003009	skeletal muscle contraction	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001011175 UniProtKB:P48788	P	Seeded From UniProt	complete
involved_in	GO:0060048	cardiac muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23693 ensembl:ENSRNOP00000024640	P	Seeded From UniProt	complete
part_of	GO:0043292	contractile fiber	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23693 ensembl:ENSRNOP00000024640	C	Seeded From UniProt	complete
part_of	GO:0030017	sarcomere	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23693 ensembl:ENSRNOP00000024640	C	Seeded From UniProt	complete
part_of	GO:0030016	myofibril	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23693 ensembl:ENSRNOP00000024640	C	Seeded From UniProt	complete
involved_in	GO:0006940	regulation of smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23693 ensembl:ENSRNOP00000024640	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23693 ensembl:ENSRNOP00000024640	C	Seeded From UniProt	complete
part_of	GO:0030017	sarcomere	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48787 ensembl:ENSMUSP00000096458	C	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48787 ensembl:ENSMUSP00000096458	P	Seeded From UniProt	complete
involved_in	GO:0006941	striated muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48787 ensembl:ENSMUSP00000096458	P	Seeded From UniProt	complete
involved_in	GO:0006937	regulation of muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48787 ensembl:ENSMUSP00000096458	P	Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48787 ensembl:ENSMUSP00000096458	P	Seeded From UniProt	complete
involved_in	GO:0001980	regulation of systemic arterial blood pressure by ischemic conditions	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48787 ensembl:ENSMUSP00000096458	P	Seeded From UniProt	complete
involved_in	GO:0001570	vasculogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48787 ensembl:ENSMUSP00000096458	P	Seeded From UniProt	complete
part_of	GO:0005861	troponin complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001978	C	Seeded From UniProt	complete
part_of	GO:0030017	sarcomere	PMID:16754800^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0030049	muscle filament sliding	Reactome:R-HSA-390522	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-5617179 Reactome:R-HSA-390598 Reactome:R-HSA-390597 Reactome:R-HSA-390595 Reactome:R-HSA-390593	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0009	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Wijnker, PJ et al. (2015) A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis. J. Mol. Cell. Cardiol. 82 93-103 PubMed GONUTS page
↑ ^2.0 ^2.1 Morita, H et al. (2006) Single-gene mutations and increased left ventricular wall thickness in the community: the Framingham Heart Study. Circulation 113 2697-705 PubMed GONUTS page
↑ Niimura, H et al. (2002) Sarcomere protein gene mutations in hypertrophic cardiomyopathy of the elderly. Circulation 105 446-51 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Takahashi-Yanaga, F et al. (2001) Functional consequences of the mutations in human cardiac troponin I gene found in familial hypertrophic cardiomyopathy. J. Mol. Cell. Cardiol. 33 2095-107 PubMed GONUTS page
↑ Mogensen, J et al. (2003) Idiopathic restrictive cardiomyopathy is part of the clinical expression of cardiac troponin I mutations. J. Clin. Invest. 111 209-16 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 al-Hillawi, E et al. (1994) Overexpression of human cardiac troponin-I and troponin-C in Escherichia coli and their purification and characterisation. Two point mutations allow high-level expression of troponin-I. Eur. J. Biochem. 225 1195-201 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Elliott, K et al. (2000) Altered regulatory properties of human cardiac troponin I mutants that cause hypertrophic cardiomyopathy. J. Biol. Chem. 275 22069-74 PubMed GONUTS page
↑ ^8.0 ^8.1 Mogensen, J et al. (2004) Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy. J. Am. Coll. Cardiol. 44 2033-40 PubMed GONUTS page
↑ Tchernev, VT et al. (2002) The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. Mol. Med. 8 56-64 PubMed GONUTS page
↑ Zhao, Y et al. (2003) Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I. J. Mol. Med. 81 297-304 PubMed GONUTS page
↑ Li, Q et al. (2003) Troponin I binds polycystin-L and inhibits its calcium-induced channel activation. Biochemistry 42 7618-25 PubMed GONUTS page
↑ Gomes, AV et al. (2002) Cardiac troponin T isoforms affect the Ca2+ sensitivity and inhibition of force development. Insights into the role of troponin T isoforms in the heart. J. Biol. Chem. 277 35341-9 PubMed GONUTS page
↑ Redwood, C et al. (2000) Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein. Circ. Res. 86 1146-52 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25771144-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Wijnker, PJ et al. (2015) A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis. J. Mol. Cell. Cardiol. 82 93-103 PubMed GONUTS page

[PMID:16754800-2] 2.0 ^2.1 Morita, H et al. (2006) Single-gene mutations and increased left ventricular wall thickness in the community: the Framingham Heart Study. Circulation 113 2697-705 PubMed GONUTS page

[PMID:11815426-3] Niimura, H et al. (2002) Sarcomere protein gene mutations in hypertrophic cardiomyopathy of the elderly. Circulation 105 446-51 PubMed GONUTS page

[PMID:11735257-4] 4.0 ^4.1 ^4.2 Takahashi-Yanaga, F et al. (2001) Functional consequences of the mutations in human cardiac troponin I gene found in familial hypertrophic cardiomyopathy. J. Mol. Cell. Cardiol. 33 2095-107 PubMed GONUTS page

[PMID:12531876-5] Mogensen, J et al. (2003) Idiopathic restrictive cardiomyopathy is part of the clinical expression of cardiac troponin I mutations. J. Clin. Invest. 111 209-16 PubMed GONUTS page

[PMID:7957210-6] 6.0 ^6.1 ^6.2 ^6.3 al-Hillawi, E et al. (1994) Overexpression of human cardiac troponin-I and troponin-C in Escherichia coli and their purification and characterisation. Two point mutations allow high-level expression of troponin-I. Eur. J. Biochem. 225 1195-201 PubMed GONUTS page

[PMID:10806205-7] 7.0 ^7.1 ^7.2 Elliott, K et al. (2000) Altered regulatory properties of human cardiac troponin I mutants that cause hypertrophic cardiomyopathy. J. Biol. Chem. 275 22069-74 PubMed GONUTS page

[PMID:15542288-8] 8.0 ^8.1 Mogensen, J et al. (2004) Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy. J. Am. Coll. Cardiol. 44 2033-40 PubMed GONUTS page

[PMID:11984006-9] Tchernev, VT et al. (2002) The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. Mol. Med. 8 56-64 PubMed GONUTS page

[PMID:12721663-10] Zhao, Y et al. (2003) Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I. J. Mol. Med. 81 297-304 PubMed GONUTS page

[PMID:12809519-11] Li, Q et al. (2003) Troponin I binds polycystin-L and inhibits its calcium-induced channel activation. Biochemistry 42 7618-25 PubMed GONUTS page

[PMID:12093807-12] Gomes, AV et al. (2002) Cardiac troponin T isoforms affect the Ca2+ sensitivity and inhibition of force development. Insights into the role of troponin T isoforms in the heart. J. Biol. Chem. 277 35341-9 PubMed GONUTS page

[PMID:10850966-13] Redwood, C et al. (2000) Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein. Circ. Res. 86 1146-52 PubMed GONUTS page

[PMID:21873635-14] 14.0 ^14.1 ^14.2 ^14.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:TNNI3

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References

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