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HUMAN:TNNC1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TNNC1 (synonyms: TNNC)
Protein Name(s) Troponin C, slow skeletal and cardiac muscles

TN-C

External Links
UniProt P63316
EMBL X07897
M37984
AF020769
BC030244
CCDS CCDS2857.1
RefSeq NP_003271.1
UniGene Hs.118845
PDB 1AP4
1IH0
1J1D
1J1E
1LXF
1MXL
1OZS
1SPY
1WRK
1WRL
2JT0
2JT3
2JT8
2JTZ
2JXL
2KDH
2KFX
2KGB
2KRD
2L1R
2L98
2MKP
2MLE
2MLF
3RV5
3SD6
3SWB
4GJE
4GJF
4GJG
PDBsum 1AP4
1IH0
1J1D
1J1E
1LXF
1MXL
1OZS
1SPY
1WRK
1WRL
2JT0
2JT3
2JT8
2JTZ
2JXL
2KDH
2KFX
2KGB
2KRD
2L1R
2L98
2MKP
2MLE
2MLF
3RV5
3SD6
3SWB
4GJE
4GJF
4GJG
ProteinModelPortal P63316
SMR P63316
BioGrid 112988
IntAct P63316
STRING 9606.ENSP00000232975
ChEMBL CHEMBL2095202
DrugBank DB01244
DB01375
DB01023
DB00922
DB00831
PhosphoSite P63316
DMDM 54042075
MaxQB P63316
PaxDb P63316
PRIDE P63316
DNASU 7134
Ensembl ENST00000232975
GeneID 7134
KEGG hsa:7134
UCSC uc003deb.3
CTD 7134
GeneCards GC03M052485
GeneReviews TNNC1
HGNC HGNC:11943
HPA CAB002450
HPA044848
MIM 191040
611879
613243
neXtProt NX_P63316
Orphanet 154
155
PharmGKB PA36632
eggNOG COG5126
HOGENOM HOG000233018
HOVERGEN HBG012180
InParanoid P63316
KO K05865
OMA MNDIYKA
OrthoDB EOG76X61W
PhylomeDB P63316
TreeFam TF318191
Reactome REACT_16969
ChiTaRS TNNC1
EvolutionaryTrace P63316
GeneWiki Troponin_C_type_1
GenomeRNAi 7134
NextBio 27913
PRO PR:P63316
Proteomes UP000005640
Bgee P63316
CleanEx HS_TNNC1
ExpressionAtlas P63316
Genevestigator P63316
GO GO:0015629
GO:0005829
GO:0005739
GO:0005634
GO:0005861
GO:0051015
GO:0005509
GO:0048306
GO:0042803
GO:0031013
GO:0031014
GO:0060048
GO:0002086
GO:0030049
GO:0043462
GO:0006937
GO:0032972
GO:0010038
GO:0055010
Gene3D 1.10.238.10
InterPro IPR011992
IPR018247
IPR002048
Pfam PF13499
SMART SM00054
PROSITE PS00018
PS50222

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0030172

troponin C binding

PMID:7852318[1]

ECO:0000315

F

binds to calcium

complete
CACAO 10661

involved_in

GO:0060048

cardiac muscle contraction

PMID:25771144[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:1990584

cardiac Troponin complex

PMID:25771144[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0060048

cardiac muscle contraction

PMID:15542288[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0055010

ventricular cardiac muscle tissue morphogenesis

PMID:15542288[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0051015

actin filament binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P19123

F

Seeded From UniProt

complete

involved_in

GO:0043462

regulation of ATPase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P19123

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:18092822[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0032972

regulation of muscle filament sliding speed

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P19123

P

Seeded From UniProt

complete

enables

GO:0031013

troponin I binding

PMID:18092822[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006937

regulation of muscle contraction

PMID:18092822[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

PMID:12840750[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

PMID:18092822[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0048306

calcium-dependent protein binding

PMID:7957210[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P19429

F

Seeded From UniProt

complete

enables

GO:0031014

troponin T binding

PMID:15542288[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P45379

F

Seeded From UniProt

complete

enables

GO:0031014

troponin T binding

PMID:8205619[7]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P45379

F

Seeded From UniProt

complete

enables

GO:0031013

troponin I binding

PMID:11735257[8]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P19429

F

Seeded From UniProt

complete

enables

GO:0031013

troponin I binding

PMID:7957210[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P19429

F

Seeded From UniProt

complete

enables

GO:0031013

troponin I binding

PMID:15542288[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P19429

F

Seeded From UniProt

complete

part_of

GO:0005861

troponin complex

PMID:12093807[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005861

troponin complex

PMID:10850966[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0051015

actin filament binding

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98779
PANTHER:PTN000552063

F

Seeded From UniProt

complete

enables

GO:0048306

calcium-dependent protein binding

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000552063
UniProtKB:P63315
UniProtKB:P63316

F

Seeded From UniProt

complete

involved_in

GO:0006937

regulation of muscle contraction

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000552063
UniProtKB:P63316

P

Seeded From UniProt

complete

part_of

GO:0005861

troponin complex

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000552063
UniProtKB:P02585
UniProtKB:P63316

C

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000552063
RGD:1309921
UniProtKB:P63315
UniProtKB:P63316

F

Seeded From UniProt

complete

involved_in

GO:0003009

skeletal muscle contraction

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000552063
UniProtKB:P02585

P

Seeded From UniProt

complete

enables

GO:0051015

actin filament binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P19123
ensembl:ENSMUSP00000131991

F

Seeded From UniProt

complete

involved_in

GO:0043462

regulation of ATPase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P19123
ensembl:ENSMUSP00000131991

P

Seeded From UniProt

complete

involved_in

GO:0032972

regulation of muscle filament sliding speed

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P19123
ensembl:ENSMUSP00000131991

P

Seeded From UniProt

complete

involved_in

GO:0014883

transition between fast and slow fiber

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P19123
ensembl:ENSMUSP00000131991

P

Seeded From UniProt

complete

involved_in

GO:0060048

cardiac muscle contraction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q4PP99
ensembl:ENSRNOP00000025606

P

Seeded From UniProt

complete

part_of

GO:0043292

contractile fiber

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q4PP99
ensembl:ENSRNOP00000025606

C

Seeded From UniProt

complete

involved_in

GO:0010038

response to metal ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q4PP99
ensembl:ENSRNOP00000025606

P

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q4PP99
ensembl:ENSRNOP00000025606

F

Seeded From UniProt

complete

involved_in

GO:0002086

diaphragm contraction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q4PP99
ensembl:ENSRNOP00000025606

P

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002048

F

Seeded From UniProt

complete

involved_in

GO:0006937

regulation of muscle contraction

PMID:2250022[12]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030049

muscle filament sliding

Reactome:R-HSA-390522

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-390598
Reactome:R-HSA-390597
Reactome:R-HSA-390595
Reactome:R-HSA-390593

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Potter, JD et al. (1995) A direct regulatory role for troponin T and a dual role for troponin C in the Ca2+ regulation of muscle contraction. J. Biol. Chem. 270 2557-62 PubMed GONUTS page
  2. ↑ 2.0 2.1 Wijnker, PJ et al. (2015) A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis. J. Mol. Cell. Cardiol. 82 93-103 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Mogensen, J et al. (2004) Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy. J. Am. Coll. Cardiol. 44 2033-40 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Julien, O et al. (2008) Tryptophan mutants of cardiac troponin C: 3D structure, troponin I affinity, and in situ activity. Biochemistry 47 597-606 PubMed GONUTS page
  5. ↑ Takeda, S et al. (2003) Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form. Nature 424 35-41 PubMed GONUTS page
  6. ↑ 6.0 6.1 al-Hillawi, E et al. (1994) Overexpression of human cardiac troponin-I and troponin-C in Escherichia coli and their purification and characterisation. Two point mutations allow high-level expression of troponin-I. Eur. J. Biochem. 225 1195-201 PubMed GONUTS page
  7. ↑ Thierfelder, L et al. (1994) Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere. Cell 77 701-12 PubMed GONUTS page
  8. ↑ Takahashi-Yanaga, F et al. (2001) Functional consequences of the mutations in human cardiac troponin I gene found in familial hypertrophic cardiomyopathy. J. Mol. Cell. Cardiol. 33 2095-107 PubMed GONUTS page
  9. ↑ Gomes, AV et al. (2002) Cardiac troponin T isoforms affect the Ca2+ sensitivity and inhibition of force development. Insights into the role of troponin T isoforms in the heart. J. Biol. Chem. 277 35341-9 PubMed GONUTS page
  10. ↑ Redwood, C et al. (2000) Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein. Circ. Res. 86 1146-52 PubMed GONUTS page
  11. ↑ 11.0 11.1 11.2 11.3 11.4 11.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  12. ↑ Schreier, T et al. (1990) Cloning, structural analysis, and expression of the human slow twitch skeletal muscle/cardiac troponin C gene. J. Biol. Chem. 265 21247-53 PubMed GONUTS page
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