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HUMAN:TMX3
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | TMX3 (synonyms: KIAA1830, TXNDC10) | |
| Protein Name(s) | Protein disulfide-isomerase TMX3
Thioredoxin domain-containing protein 10 Thioredoxin-related transmembrane protein 3 | |
| External Links | ||
| UniProt | Q96JJ7 | |
| EMBL | AB058733 AK000800 AK122715 BX647846 BC032325 BC093792 BC093794 | |
| CCDS | CCDS32840.1 | |
| RefSeq | NP_061895.3 | |
| UniGene | Hs.440534 | |
| ProteinModelPortal | Q96JJ7 | |
| SMR | Q96JJ7 | |
| BioGrid | 119991 | |
| IntAct | Q96JJ7 | |
| MINT | MINT-3054729 | |
| STRING | 9606.ENSP00000299608 | |
| PhosphoSite | Q96JJ7 | |
| DMDM | 78103208 | |
| MaxQB | Q96JJ7 | |
| PaxDb | Q96JJ7 | |
| PeptideAtlas | Q96JJ7 | |
| PRIDE | Q96JJ7 | |
| DNASU | 54495 | |
| Ensembl | ENST00000299608 ENST00000562706 | |
| GeneID | 54495 | |
| KEGG | hsa:54495 | |
| UCSC | uc002lkf.3 uc002lkg.4 | |
| CTD | 54495 | |
| GeneCards | GC18M066340 | |
| HGNC | HGNC:24718 | |
| HPA | HPA014157 | |
| neXtProt | NX_Q96JJ7 | |
| PharmGKB | PA164726632 | |
| eggNOG | COG0526 | |
| GeneTree | ENSGT00760000119201 | |
| HOGENOM | HOG000154655 | |
| InParanoid | Q96JJ7 | |
| KO | K09585 | |
| OMA | VQFINNI | |
| OrthoDB | EOG747PKC | |
| PhylomeDB | Q96JJ7 | |
| TreeFam | TF313807 | |
| GeneWiki | TMX3 | |
| GenomeRNAi | 54495 | |
| NextBio | 56824 | |
| PRO | PR:Q96JJ7 | |
| Proteomes | UP000005640 | |
| Bgee | Q96JJ7 | |
| CleanEx | HS_TXNDC10 | |
| ExpressionAtlas | Q96JJ7 | |
| Genevestigator | Q96JJ7 | |
| GO | GO:0009986 GO:0005783 GO:0005789 GO:0016021 GO:0003756 GO:0045454 GO:0006457 GO:0034976 | |
| Gene3D | 3.40.30.10 | |
| InterPro | IPR012336 IPR017937 IPR013766 | |
| Pfam | PF00085 | |
| SUPFAM | SSF52833 | |
| PROSITE | PS00194 PS51352 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016972 |
thiol oxidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0018171 |
peptidyl-cysteine oxidation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0018171 |
peptidyl-cysteine oxidation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002498198 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016972 |
thiol oxidase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002498198 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2442418 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002498198 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BXZ1 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045454 |
cell redox homeostasis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003756 |
protein disulfide isomerase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031092 |
platelet alpha granule membrane |
Reactome:R-HSA-481044 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-481044 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002576 |
platelet degranulation |
Reactome:R-HSA-114608 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016853 |
isomerase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Haugstetter, J et al. (2005) Identification and characterization of a novel thioredoxin-related transmembrane protein of the endoplasmic reticulum. J. Biol. Chem. 280 8371-80 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Holbrook, LM et al. (2010) Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation. Br. J. Haematol. 148 627-37 PubMed GONUTS page
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