HUMAN:TMX1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TMX1 (synonyms: TMX, TXNDC, TXNDC1)
Protein Name(s)	Thioredoxin-related transmembrane protein 1 Thioredoxin domain-containing protein 1 Transmembrane Trx-related protein
External Links
UniProt	Q9H3N1
EMBL	AB048246 AY358640 AK075395 AK312905 AL080080 AL591807 CH471078 BC036460 BC056874
CCDS	CCDS41953.1
PIR	T12471
RefSeq	NP_110382.3
UniGene	Hs.125221
PDB	1X5E
PDBsum	1X5E
ProteinModelPortal	Q9H3N1
SMR	Q9H3N1
BioGrid	123510
IntAct	Q9H3N1
MINT	MINT-3067322
STRING	9606.ENSP00000393316
PhosphoSite	Q9H3N1
DMDM	47117631
MaxQB	Q9H3N1
PaxDb	Q9H3N1
PeptideAtlas	Q9H3N1
PRIDE	Q9H3N1
DNASU	81542
Ensembl	ENST00000457354
GeneID	81542
KEGG	hsa:81542
UCSC	uc001wza.4
CTD	81542
GeneCards	GC14P051706
HGNC	HGNC:15487
HPA	HPA003085
MIM	610527
neXtProt	NX_Q9H3N1
PharmGKB	PA37968
eggNOG	COG0526
GeneTree	ENSGT00390000011580
HOGENOM	HOG000045750
InParanoid	Q9H3N1
OMA	APWTHGR
OrthoDB	EOG7KM5VC
PhylomeDB	Q9H3N1
TreeFam	TF106376
EvolutionaryTrace	Q9H3N1
GeneWiki	TMX1
GenomeRNAi	81542
NextBio	71773
PRO	PR:Q9H3N1
Proteomes	UP000005640
Bgee	Q9H3N1
CleanEx	HS_TXNDC1
ExpressionAtlas	Q9H3N1
Genevestigator	Q9H3N1
GO	GO:0005783 GO:0005789 GO:0016021 GO:0005730 GO:0015036 GO:0003756 GO:0045454 GO:0006457 GO:0034976
Gene3D	3.40.30.10
InterPro	IPR012336 IPR017937 IPR013766
Pfam	PF00085
SUPFAM	SSF52833
PROSITE	PS00194 PS51352

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0015036	disulfide oxidoreductase activity	PMID:22228764	ECO:0000314			F		In order for Ricin to intoxicate the host cell, its disulfide bridge has to be reduced. It has been shown that protein disulfide isomerase (PDI) has the ability to reduce the disulfide bond. However, reduction can still occur even when PDI is depleted, suggesting that other proteins are also responsible to reduce Ricin. Transmenbrane Thioredoxin related protein (TMX) has been found to reduce Ricin. Figure 2 shows that TMX is needed to reduce Ricin. In Lane 1 when TMX is added, Ricin is reduced (the RTA band), whereas in lane 3 with no TMX, Ricin is not reduced.	complete CACAO 3765
enables	GO:0015036	disulfide oxidoreductase activity	PMID:22228764	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	PMID:11152479	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0015036	disulfide oxidoreductase activity	PMID:11152479	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:11152479	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045454	cell redox homeostasis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013766 InterPro:IPR017937	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0249	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
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References

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