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HUMAN:TIMP1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | TIMP1 (synonyms: CLGI, TIMP) | |
| Protein Name(s) | Metalloproteinase inhibitor 1
Erythroid-potentiating activity EPA Fibroblast collagenase inhibitor Collagenase inhibitor Tissue inhibitor of metalloproteinases 1 TIMP-1 | |
| External Links | ||
| UniProt | P01033 | |
| EMBL | X03124 X02598 M12670 M59906 S68252 BC000866 L47361 D11139 | |
| CCDS | CCDS14281.1 | |
| PIR | A93372 | |
| RefSeq | NP_003245.1 | |
| UniGene | Hs.522632 | |
| PDB | 1D2B 1LQN 1OO9 1UEA 2J0T 3MA2 3V96 | |
| PDBsum | 1D2B 1LQN 1OO9 1UEA 2J0T 3MA2 3V96 | |
| ProteinModelPortal | P01033 | |
| SMR | P01033 | |
| BioGrid | 112932 | |
| DIP | DIP-1107N | |
| IntAct | P01033 | |
| MINT | MINT-2981826 | |
| STRING | 9606.ENSP00000218388 | |
| MEROPS | I35.001 | |
| PhosphoSite | P01033 | |
| UniCarbKB | P01033 | |
| DMDM | 135850 | |
| MaxQB | P01033 | |
| PaxDb | P01033 | |
| PRIDE | P01033 | |
| DNASU | 7076 | |
| Ensembl | ENST00000218388 | |
| GeneID | 7076 | |
| KEGG | hsa:7076 | |
| UCSC | uc004dif.3 | |
| CTD | 7076 | |
| GeneCards | GC0XP047441 | |
| HGNC | HGNC:11820 | |
| HPA | CAB022360 | |
| MIM | 305370 | |
| neXtProt | NX_P01033 | |
| PharmGKB | PA36526 | |
| eggNOG | NOG259409 | |
| HOGENOM | HOG000285981 | |
| HOVERGEN | HBG068749 | |
| InParanoid | P01033 | |
| KO | K16451 | |
| OMA | SSIPCKL | |
| OrthoDB | EOG79GT74 | |
| PhylomeDB | P01033 | |
| TreeFam | TF317409 | |
| Reactome | REACT_118682 | |
| EvolutionaryTrace | P01033 | |
| GeneWiki | TIMP1 | |
| GenomeRNAi | 7076 | |
| NextBio | 27675 | |
| PMAP-CutDB | P01033 | |
| PRO | PR:P01033 | |
| Proteomes | UP000005640 | |
| Bgee | P01033 | |
| CleanEx | HS_TIMP1 | |
| ExpressionAtlas | P01033 | |
| Genevestigator | P01033 | |
| GO | GO:0005604 GO:0005576 GO:0005615 GO:0070062 GO:0031093 GO:0005125 GO:0046872 GO:0008191 GO:0007568 GO:0007596 GO:0022617 GO:0030198 GO:0043066 GO:0010951 GO:0051045 GO:0048553 GO:1901164 GO:0030168 GO:0002576 GO:0008284 GO:2001044 GO:0034097 GO:0043434 | |
| Gene3D | 3.90.370.10 | |
| InterPro | IPR001134 IPR001820 IPR008993 IPR015611 IPR027465 | |
| PANTHER | PTHR11844 PTHR11844:SF20 | |
| Pfam | PF00965 | |
| SMART | SM00206 | |
| SUPFAM | SSF50242 | |
| PROSITE | PS50189 PS00288 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0008191 |
metalloendopeptidase inhibitor activity |
ECO:0000314 |
F |
From Figure 3, High expression of TIMP-1 has a lower overall survival rate compared to no TIMP-1 expression in LSCC tissue. Positive lymph node metastasis had a lower overall survival rate as well |
complete | |||||
| GO:0008191 |
metalloendopeptidase inhibitor activity |
ECO:0000314 |
F |
Figure 1 shows that as MP inhibitory activity increases the percent inhibition also increases. This indicates that TIMP-1 is exhibiting inhibitor properties. |
complete | |||||
|
involved_in |
GO:1905049 |
negative regulation of metallopeptidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030414 |
peptidase inhibitor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1901164 |
negative regulation of trophoblast cell migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2001044 |
regulation of integrin-mediated signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051045 |
negative regulation of membrane protein ectodomain proteolysis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043086 |
negative regulation of catalytic activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010951 |
negative regulation of endopeptidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008191 |
metalloendopeptidase inhibitor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008191 |
metalloendopeptidase inhibitor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051045 |
negative regulation of membrane protein ectodomain proteolysis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000931945 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034097 |
response to cytokine |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000931946 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031012 |
extracellular matrix |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98752 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010951 |
negative regulation of endopeptidase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000931945 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010033 |
response to organic substance |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000931945 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009725 |
response to hormone |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000931946 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008191 |
metalloendopeptidase inhibitor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0025879 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000931945 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0002020 |
protease binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000931945 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0008083 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031012 |
extracellular matrix |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P12032 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005604 |
basement membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P12032 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002248 |
connective tissue replacement involved in inflammatory response wound healing |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P12032 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051216 |
cartilage development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P30120 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043434 |
response to peptide hormone |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P30120 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P30120 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042060 |
wound healing |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P30120 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034097 |
response to cytokine |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P30120 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010033 |
response to organic substance |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P30120 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007568 |
aging |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P30120 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005604 |
basement membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P30120 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0002020 |
protease binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P30120 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001775 |
cell activation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P30120 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008191 |
metalloendopeptidase inhibitor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0044267 |
cellular protein metabolic process |
Reactome:R-HSA-392499 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043687 |
post-translational protein modification |
Reactome:R-HSA-597592 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031093 |
platelet alpha granule lumen |
Reactome:R-HSA-481007 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0022617 |
extracellular matrix disassembly |
Reactome:R-HSA-1474228 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019221 |
cytokine-mediated signaling pathway |
Reactome:R-HSA-6785807 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005788 |
endoplasmic reticulum lumen |
Reactome:R-HSA-8952289 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-6789615 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0002576 |
platelet degranulation |
Reactome:R-HSA-114608 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008191 |
metalloendopeptidase inhibitor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030414 |
peptidase inhibitor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008083 |
growth factor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004857 |
enzyme inhibitor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010466 |
negative regulation of peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Ma, J et al. (2014) Upregulated TIMP-1 correlates with poor prognosis of laryngeal squamous cell carcinoma. Int J Clin Exp Pathol 7 246-54 PubMed GONUTS page
- ↑ Greger, R (1985) Ion transport mechanisms in thick ascending limb of Henle's loop of mammalian nephron. Physiol. Rev. 65 760-97 PubMed GONUTS page
- ↑ 3.0 3.1 Wada, K et al. (1998) Cloning of three Caenorhabditis elegans genes potentially encoding novel matrix metalloproteinases. Gene 211 57-62 PubMed GONUTS page
- ↑ Batra, J et al. (2012) Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure. J. Biol. Chem. 287 15935-46 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Nadeem, L et al. (2011) Nodal signals through activin receptor-like kinase 7 to inhibit trophoblast migration and invasion: implication in the pathogenesis of preeclampsia. Am. J. Pathol. 178 1177-89 PubMed GONUTS page
- ↑ Jung, KK et al. (2006) Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein. EMBO J. 25 3934-42 PubMed GONUTS page
- ↑ 8.0 8.1 Hundhausen, C et al. (2003) The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. Blood 102 1186-95 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 Docherty, AJ et al. () Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity. Nature 318 66-9 PubMed GONUTS page
- ↑ 10.0 10.1 Gasson, JC et al. () Molecular characterization and expression of the gene encoding human erythroid-potentiating activity. Nature 315 768-71 PubMed GONUTS page
- ↑ Van Ranst, M et al. (1991) The cytokine-protease connection: identification of a 96-kD THP-1 gelatinase and regulation by interleukin-1 and cytokine inducers. Cytokine 3 231-9 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 12.3 12.4 12.5 12.6 12.7 12.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
c
- GO:0051216 ! cartilage development
- Catarrhini
- GO:0044267 ! cellular protein metabolic process
- GO:0001775 ! cell activation
- Chordata
- GO:0002248 ! connective tissue replacement involved in inflammatory response wound healing
- Craniata
- GO:0019221 ! cytokine-mediated signaling pathway
- GO:0005125 ! cytokine activity
e
- GO:0005788 ! endoplasmic reticulum lumen
- GO:0004857 ! enzyme inhibitor activity
- Euarchontoglires
- Eukaryota
- Euteleostomi
- Eutheria
- GO:0031012 ! extracellular matrix
- GO:0005615 ! extracellular space
- GO:0005576 ! extracellular region
- GO:0070062 ! extracellular exosome
- GO:0022617 ! extracellular matrix disassembly
m
n
- GO:1905049 ! negative regulation of metallopeptidase activity
- GO:1901164 ! negative regulation of trophoblast cell migration
- GO:0051045 ! negative regulation of membrane protein ectodomain proteolysis
- GO:0043066 ! negative regulation of apoptotic process
- GO:0043086 ! negative regulation of catalytic activity
- GO:0010951 ! negative regulation of endopeptidase activity
- GO:0010466 ! negative regulation of peptidase activity
p
r
