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HUMAN:THIOM

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TXN2 (synonyms: TRX2)
Protein Name(s) Thioredoxin, mitochondrial

MTRX Mt-Trx Thioredoxin-2

External Links
UniProt Q99757
EMBL AF480262
U78678
AF276920
CR456601
CR541896
CR541917
AL022313
CH471095
BC013726
BC050610
CCDS CCDS13928.1
RefSeq NP_036605.2
XP_006724289.1
UniGene Hs.211929
PDB 1UVZ
1W4V
1W89
PDBsum 1UVZ
1W4V
1W89
ProteinModelPortal Q99757
SMR Q99757
BioGrid 117356
IntAct Q99757
STRING 9606.ENSP00000216185
BindingDB Q99757
ChEMBL CHEMBL2189153
PhosphoSite Q99757
DMDM 20455529
MaxQB Q99757
PaxDb Q99757
PRIDE Q99757
DNASU 25828
Ensembl ENST00000216185
ENST00000403313
GeneID 25828
KEGG hsa:25828
UCSC uc003apk.1
CTD 25828
GeneCards GC22M036863
HGNC HGNC:17772
HPA CAB008681
HPA000994
MIM 609063
neXtProt NX_Q99757
PharmGKB PA38245
eggNOG COG0526
GeneTree ENSGT00530000064086
HOVERGEN HBG009243
InParanoid Q99757
KO K03671
OMA ATTFNIQ
OrthoDB EOG7VTDQP
PhylomeDB Q99757
TreeFam TF314517
Reactome REACT_172715
ChiTaRS TXN2
EvolutionaryTrace Q99757
GeneWiki TXN2
GenomeRNAi 25828
NextBio 47113
PRO PR:Q99757
Proteomes UP000005640
Bgee Q99757
CleanEx HS_TXN2
ExpressionAtlas Q99757
Genevestigator Q99757
GO GO:0030425
GO:0005759
GO:0005739
GO:0043025
GO:0005730
GO:0033743
GO:0008113
GO:0015035
GO:0045454
GO:0031669
GO:0006662
GO:0048678
GO:0042493
GO:0009749
GO:0009725
GO:0001666
GO:0007584
GO:0014070
GO:0006979
Gene3D 3.40.30.10
InterPro IPR005746
IPR012336
IPR017937
IPR013766
PANTHER PTHR10438
Pfam PF00085
SUPFAM SSF52833
TIGRFAMs TIGR01068
PROSITE PS00194
PS51352

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005739

mitochondrion

PMID:12032145[1]

ECO:0000314

C

Figure 5 and paragraph above support the localization of mtTrx in the mitochondria.

complete
CACAO 4157

part_of

GO:0005739

mitochondrion

PMID:12032145[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0048678

response to axon injury

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97615
ensembl:ENSRNOP00000060694

P

Seeded From UniProt

complete

enables

GO:0044877

protein-containing complex binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97615
ensembl:ENSRNOP00000060694

F

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97615
ensembl:ENSRNOP00000060694

C

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97615
ensembl:ENSRNOP00000060694

P

Seeded From UniProt

complete

enables

GO:0033743

peptide-methionine (R)-S-oxide reductase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97615
ensembl:ENSRNOP00000060694

F

Seeded From UniProt

complete

involved_in

GO:0031669

cellular response to nutrient levels

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97615
ensembl:ENSRNOP00000060694

P

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97615
ensembl:ENSRNOP00000060694

C

Seeded From UniProt

complete

enables

GO:0015035

protein disulfide oxidoreductase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97615
ensembl:ENSRNOP00000060694

F

Seeded From UniProt

complete

involved_in

GO:0014070

response to organic cyclic compound

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97615
ensembl:ENSRNOP00000060694

P

Seeded From UniProt

complete

involved_in

GO:0009749

response to glucose

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97615
ensembl:ENSRNOP00000060694

P

Seeded From UniProt

complete

involved_in

GO:0009725

response to hormone

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97615
ensembl:ENSRNOP00000060694

P

Seeded From UniProt

complete

enables

GO:0008113

peptide-methionine (S)-S-oxide reductase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97615
ensembl:ENSRNOP00000060694

F

Seeded From UniProt

complete

involved_in

GO:0006979

response to oxidative stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97615
ensembl:ENSRNOP00000060694

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97615
ensembl:ENSRNOP00000060694

C

Seeded From UniProt

complete

involved_in

GO:0001666

response to hypoxia

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97615
ensembl:ENSRNOP00000060694

P

Seeded From UniProt

complete

involved_in

GO:0006662

glycerol ether metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005746

P

Seeded From UniProt

complete

enables

GO:0015035

protein disulfide oxidoreductase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005746

F

Seeded From UniProt

complete

involved_in

GO:0045454

cell redox homeostasis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005746
InterPro:IPR013766
InterPro:IPR017937

P

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

Reactome:R-HSA-9035484
Reactome:R-HSA-9035227
Reactome:R-HSA-3697894
Reactome:R-HSA-3323050
Reactome:R-HSA-3322995

ECO:0000304

author statement supported by traceable reference used in manual assertion





C

Seeded From UniProt

complete

involved_in

GO:0000098

sulfur amino acid catabolic process

Reactome:R-HSA-1614558

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0249

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496
UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Chen, Y et al. (2002) Overexpressed human mitochondrial thioredoxin confers resistance to oxidant-induced apoptosis in human osteosarcoma cells. J. Biol. Chem. 277 33242-8 PubMed GONUTS page
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